Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Oza, Palak P.; Kashfi, Khosrow

doi:10.1016/j.niox.2022.08.003

Cited by 8 publications

(5 citation statements)

References 450 publications

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“…Such studies could identify specific molecular targets and critical signaling pathways, positioning H 2 S as a targeted strategy for managing diabetes-related renal damage. Viral infections typically cause harm through direct host cell infection and inflammation-related alterations (Oza and Kashfi, 2022). In severe instances of specific viral infections, such as COVID-19, a hyperinflammatory reaction known as a cytokine storm can ensue, leading to substantial endothelial damage, thrombosis, respiratory failure, and ultimately, mortality (Oza and Kashfi, 2022).…”

Section: Nahs Impedes the Transformation Of Fibroblasts Into Myofibro...mentioning

confidence: 99%

“…Viral infections typically cause harm through direct host cell infection and inflammation-related alterations (Oza and Kashfi, 2022). In severe instances of specific viral infections, such as COVID-19, a hyperinflammatory reaction known as a cytokine storm can ensue, leading to substantial endothelial damage, thrombosis, respiratory failure, and ultimately, mortality (Oza and Kashfi, 2022). In addition to antiviral treatments, it is imperative to address these complications through therapeutic interventions.…”

Section: Nahs Impedes the Transformation Of Fibroblasts Into Myofibro...mentioning

confidence: 99%

See 1 more Smart Citation

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

Sun,

Lu,

Zhu

et al. 2024

Pharmacol Rev

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Section: Nahs Impedes the Transformation Of Fibroblasts Into Myofibro...mentioning

confidence: 99%

Section: Nahs Impedes the Transformation Of Fibroblasts Into Myofibro...mentioning

confidence: 99%

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

Sun,

Lu,

Zhu

et al. 2024

Pharmacol Rev

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“…The antiviral activity of NO has been reported for many types of viruses, most typically, DNA viruses such as murine poxvirus, herpesviruses, and some RNA viruses [ 55 ]. The direct action of NO as an antiviral agent involves the inhibition of viral replication and viral entry into the host [ 70 , 71 ]. In 1999, Saura et al demonstrated that the in vitro replication of the RNA virus coxsackievirus is suppressed by NO-dependent S -nitrosylation that causes the inactivation of viral cysteine protease, an enzyme necessary for replication [ 72 ].…”

Section: Antiviral Activity Of Nomentioning

confidence: 99%

Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling’s Vitamin C Therapy

et al. 2023

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Linus Pauling, who was awarded the Nobel Prize in Chemistry, suggested that a high dose of vitamin C (L-ascorbic acid) might work as a prevention or treatment for the common cold. Vitamin C therapy was tested in clinical trials, but clear evidence was not found at that time. Although Pauling’s proposal has been strongly criticized for a long time, vitamin C therapy has continued to be tested as a treatment for a variety of diseases, including coronavirus infectious disease 2019 (COVID-19). The pathogen of COVID-19, SARS-CoV-2, belongs to the β-coronavirus lineage, which includes human coronavirus, severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). This review intends to shed new light on vitamin C antiviral activity that may prevent SARS-CoV-2 infection through the chemical production of nitric oxide (NO). NO is a gaseous free radical that is largely produced by the enzyme NO synthase (NOS) in cells. NO produced by upper epidermal cells contributes to the inactivation of viruses and bacteria contained in air or aerosols. In addition to enzymatic production, NO can be generated by the chemical reduction of inorganic nitrite (NO2−), an alternative mechanism for NO production in living organisms. Dietary vitamin C, largely contained in fruits and vegetables, can reduce the nitrite in saliva to produce NO in the oral cavity when chewing foods. In the stomach, salivary nitrite can also be reduced to NO by vitamin C secreted from the epidermal cells of the stomach. The strong acidic pH of gastric juice facilitates the chemical reduction of salivary nitrite to produce NO. Vitamin C contributes in multiple ways to the host innate immune system as a first-line defense mechanism against pathogens. Highlighting chemical NO production by vitamin C, we suggest that controversies on the therapeutic effects of vitamin C in previous clinical trials may partly be due to less appreciation of the pleiotropic functions of vitamin C as a universal bioreductant.

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“…NO via endothelial cells plays an important role in regulating blood vessels and blood flow. NO also has a significant contribution to homeostasis in blood vessels, through the regulation of platelet aggregation and adhesion to the endothelium, in regulation of clotting in blood vessels, (Radomski et al, 1991), regulates the adhesion of neutrophil cells to the endothelium so that it can inhibit the increased process of inflammation (Oza et al, 2022). Organ failure in patients with falciparum malaria is associated with neutrophil activation and endothelial damage.…”

Section: Histology Of Mice Liver Cellsmentioning

confidence: 99%

Methanol Extract Alstonia scholaris L. R. Br as Hepatoprotective Mice (Mus musculus) Infected with Plasmodium berghei ANKA Strains

Kaihena,

Nindatu,

Ukratalo

2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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Alstonia scholaris L. R. Br is one of the traditional plants that contain natural antioxidant compounds which are thought to be able to repair damage to the liver cells of mice (Mus musculus) infected with Plasmodium berghei strain ANKA. This study aimed to determine the effect of methanol extract of Alstonia scholaris L. R. Br stem bark on levels of SGPT enzymes and liver cells of mice (Mus musculus) infected with Plasmodium berghei strain ANKA. Mice with a body weight of 20-30 g were infected with Plasmodium berghei as much as 0.1 ml per head and left until the percentage of parasitemia reached 1-5%. Then mice (Mus musculus) were given methanol extract of Alstonia scholaris L. R. Br stem bark at doses of 1, 10, 100, and 200 mg/kg BW for 4 consecutive days. After that, surgery was performed to take blood to observe SGPT enzyme levels and mice liver cells to be prepared with Hematoxylin Eosin (HE) staining. The results of ANOVA showed that the methanol extract of Alstonia scholaris L. R. Br stems bark doses of 1 mg/kg BW, 10 mg/kg BW, 100 mg/kg BW and 200 mg/kg BW could reduce SGPT enzyme levels and repair damage to the liver cells of mice infected with Plasmodium berghei ANKA strains

show abstract

Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promise

Cited by 8 publications

References 450 publications

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

Pleiotropic Functions of Nitric Oxide Produced by Ascorbate for the Prevention and Mitigation of COVID-19: A Revaluation of Pauling’s Vitamin C Therapy

Methanol Extract Alstonia scholaris L. R. Br as Hepatoprotective Mice (Mus musculus) Infected with Plasmodium berghei ANKA Strains

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