Utility of near infrared spectrophotometry in mesenteric ischemia: An experimental study

Abstract

This study investigated the effectiveness of near infrared (NIR) spectrophotometry for measuring abdominal saturation in a rat model of induced mesenteric ischemia. This was a randomized, controlled, non-blinded interventional animal study. Twenty-eight male Sprague Dawley rats were randomly allocated into four groups. Following induction of anesthesia, the abdominal region was shaved and intra-abdominal access was achieved through a 4-cm midline incision and basal measurements were performed using an INVOS-5100c device. The rats were grouped on the basis of rSO 2 measurement times. Mesenteric artery ligation was not performed on the control group rats. From the rest of the mesenteric artery ligated rats, measurements were taken at 30 min, at 2 h and at 6 h. Measurements were repeated using NIR spectrophotometry probes after the abdomen was surgically closed. Following the measurements, the abdomen was reopened and small intestine tissue specimens were taken for histopathological examination. Initial and final NIR spectrophotometry measurements were compared. No statistically significant difference was found in the group 1 between basal rSO 2 values and post-incision values (p ¼ 0.748). There was a significant variation between the initial and final measurements in groups 2, 3, and 4 (p ¼ 0.018). Although various radiological or biochemical markers are available for detecting mesenteric ischemia, the use of NIR spectrophotometry can be considered a good non-invasive alternative method for early diagnosis of acute mesenteric ischemia.

Measurement of Tissue Oximetry in Standing Unsedated and Sedated Horses

“…The INVOS 5100c tissue oximeter (Medtronic, Minneapolis, MN, USA) is a twowavelength, dual-receiving optode oximeter that can simultaneously monitor StO 2 or cerebral oximetry (rSO 2 ) at up to four different locations on the body [18][19][20]. The monitor is commercially available and has previously been used by McConnell et al [21] to monitor rSO 2 in horses.…”

A new technique in the evaluation of strangulated and incarcerated hernias: Near infrared spectroscopy

“…Lower intestinal oxygenation was determined compared to pre-mesenteric artery ligation values and compared to healthy animals. [11] Although ultrasonography can be used to assess oxygenation in the hernia sac in incarcerated hernias, it has 74.5% specificity and 92% sensitivity. In addition, ultrasonographic findings may vary depending on the experience of the operator.…”