Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves’ ophthalmopathy

Wu, Dide; Zhu, Huilian; Hong, Shubin; Li, Bin; Zou, Mengsha; Ma, Xiaoyi; Zhao, Xiaojuan; Park, Wan; Yang, Zhiyun; Li, Yanbing; Xiao, Hang

doi:10.1016/j.ejrad.2021.109815

Cited by 14 publications

(26 citation statements)

References 43 publications

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“…Therefore, in this study, the coronal TSE DWI sequence was adopted to enable the bilateral LG to be clearly displayed, and the ROI can be accurately delineated on the ADC map. No signi cant statistical difference was found in ADC values of LG between the active and inactive groups, which was inconsistent with some previous studies [10]. Further research is needed to determine whether the result is related to sample size, machine model, or B values.…”

Section: Discussioncontrasting

confidence: 79%

“…Some studies have shown that the T2 value is valuable in the early evaluation of cartilage degeneration and myocardial disease [23,24]. Moreover, the T2 value of LG is a good indicator for GO staging [10]. In our study, the T2 value of LG (especially in model I and II) resulted as the best predictor for GO staging.…”

Section: Discussionsupporting

confidence: 53%

“…DWI is a functional MRI technique that is increasingly applied in GO staging, therapeutic evaluation, and prognostic estimation [10,25]. The DWI signal re ects the degree of diffusivity of water molecules.…”

Section: Discussionmentioning

confidence: 99%

“…However, some CT and MRI studies also suggested that a direct lacrimal gland (LG) involvement leading to a decrease in tear secretion with an LG volume is higher in patients with GO than in healthy controls [6-8]. Thus, whether the morphology and MRI parameters of LG can improve the staging assessment in GO remains debatable [9,10]. Moreover, most of the MRI parameters are either semiquantitative or based on signal intensity, which is not directly proportional to speci c tissue properties.…”

Section: Introductionmentioning

confidence: 99%

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The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores

et al. 2022

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To explore radiological changes of the lacrimal gland (LG) in Graves' ophthalmopathy (GO) and whether a combination of MRI parameters and clinical indicators can better predict individual clinical manifestation of GO compared to clinical activity scores (CAS) assessment. MethodsA total of 28 patients with GO (56 eyes) were enrolled between July 2020 and July 2021. Patients were classi ed into either the active GO group ( CAS ≥ 3) and the inactive GO group ( CAS < 3). MRI data and clinical data of LG were collected. The diagnostic performance of MRI parameters and models was assessed by receiver operating characteristic curve analysis. Logistic regression predictive models for staging GO were compared. ResultsThere were statistically signi cant differences in T2-mapping values (p < 0.001), the proportion of mild or no obvious redness of conjunctival (p < 0.001), and the proportion of swelling of caruncle or plica (p < 0.001) between inactive and active groups. In MRI based logistic regression model, the T2-mapping value was an independent risk factor (AUC = 0.832). When combining MRI and clinical indicators, T2-mapping value and age resulted as independent risk factors (AUC = 0.928). Swelling of eyelids, redness of conjunctiva, swelling of conjunctiva, swelling of caruncle or plica, and spontaneous retrobulbar pain can be replaced by other objective indicators (AUC = 0.937, 0.852, 0.876, 0.896, and 0.891, respectively). ConclusionThe combination of the T2-mapping value of LG and clinical indicators can improve the stage prediction of Graves' ophthalmopathy compared to CAS and provide a new idea for improving the objecti cation level of GO data collection.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores

et al. 2022

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“…In GO the lacrimal gland might increase in size and show hyperintensity on T2 due to inflammatory edema [18]. Although it is seen in GO, other diagnoses as: lymphoma, IOI, IgG4-ROD, cellulitis, sarcoidosis and GPA are more likely [19 • ].…”

Section: Involvement Of Adjacent Structuresmentioning

confidence: 99%

Orbital Muscle Enlargement: What if It’s Not Graves’ Disease?

Lakerveld

Gijp

2022

Curr Radiol Rep

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Purpose of Review To provide the radiologist with tools to recognize findings atypical for Graves’ ophthalmopathy and differentiate between the most important and common alternative causes of extraocular muscle enlargement on CT and MR imaging. Recent findings We introduce five ‘red flags’ representing features that are atypical for Graves’ ophthalmopathy: unilateral disease, atypical pattern of muscle involvement, adjacent structure involvement, restricted diffusion, and absence of pain. Summary About 95% of the cases with extraocular enlargement are due to Graves’ ophthalmopathy, other causes are less well known and recognized. The ‘red flags’ may aid in recognizing and suggesting alternative diagnoses.

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Application of Quantitative MRI in Thyroid Eye Disease: Imaging Techniques and Clinical Practices

Zhang,

Lu,

Liu

et al. 2023

Magnetic Resonance Imaging

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Thyroid eye disease (TED) is a complex autoimmune disorder that impairs various orbital structures, leading to cosmetic damage and vision loss. Magnetic resonance imaging (MRI) is a fundamental diagnostic tool utilized in clinical settings of TED, for its accurate demonstration of orbital lesions and indication of disease conditions. The application of quantitative MRI has brought a new prospect to the management and research of TED, offering more detailed information on morphological and functional changes in the orbit. Therefore, many researchers concentrated on the implementation of different quantitative MRI techniques on TED for the exploration of clinical practices. Despite the abundance of studies utilizing quantitative MRI in TED, there remain considerable barriers and disputes on the best exploitation of this tool. This could possibly be attributed to the complexity of TED and the fast development of MRI techniques. It is necessary that clinical and radiological aspects of quantitative MRI in TED be better integrated into comprehensive insights. Hence, this review traces back 30 years of publications regarding quantitative MRI utilized in TED and elucidates this promising application in the facets of imaging techniques and clinical practices. We believe that a deeper understanding of the application of quantitative MRI in TED will enhance the efficacy of the multidisciplinary management of TED.Level of Evidence2Technical EfficacyStage 3

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Utility of multi-parametric quantitative magnetic resonance imaging of the lacrimal gland for diagnosing and staging Graves’ ophthalmopathy

Cited by 14 publications

References 43 publications

The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores

The combination of T2-mapping value of lacrimal gland and clinical indicators can improve the stage prediction of Graves’ ophthalmopathy compared to clinical activity scores

Orbital Muscle Enlargement: What if It’s Not Graves’ Disease?

Application of Quantitative MRI in Thyroid Eye Disease: Imaging Techniques and Clinical Practices

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