Utility of Microporous Polysaccharide Hemosphere on Anterolateral Thigh Free Flap Donor Site Complications

Benjamin, Tania; David, Abel P.; Zebolsky, Aaron L.; Shuman, Elizabeth A.; Park, Andrea M.; Heaton, Chase M.; Knott, P. Daniel; Seth, Rahul

doi:10.1089/fpsam.2021.0141

Cited by 1 publication

(3 citation statements)

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“…This study represents the first randomized controlled trial evaluating topical MPH administered to ALT donor site wound beds after free flap harvest for head and neck reconstruction. Despite promising animal studies 14,15 and a recent retrospective study of MPH use in ALT donor sites where the use of MPH was associated with lower rates of seroma formation and were associated with earlier drain removal, 19 we did not detect a significant difference in postoperative drain output, seroma development, or hematoma development with the use of MPH. This is consistent with other randomized controlled trials that found no significant improvement in postoperative surgical site drainage with MPH after mastectomy or total thyroidectomy.…”

Section: Discussioncontrasting

confidence: 91%

“…To detect a 20% reduction in drain output with a significance level of 0.05 and power of 0.8, a sample size of 25 patients in each group was required, assuming mean output of 500 ml and standard deviation of 125 ml based on preliminary data. 19 Descriptive statistics were used to report continuous and categorical variables. Student's t-test, Mann-Whitney U, chi-square, and Fisher exact tests were used for analysis as appropriate.…”

Section: Discussionmentioning

confidence: 99%

“…A sample size calculation was performed before initiating the study. To detect a 20% reduction in drain output with a significance level of 0.05 and power of 0.8, a sample size of 25 patients in each group was required, assuming mean output of 500 ml and standard deviation of 125 ml based on preliminary data 19 …”

Section: Methodsmentioning

confidence: 99%

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Effect of microporous polysaccharide hemospheres on anterolateral thigh free flap donor site complications

David

Zebolsky

Park

et al. 2022

Laryngoscope Investig Oto

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Background: Postoperative seroma is the most common donor site complication following anterolateral thigh (ALT) free flap harvest for head and neck reconstruction.The utility of novel microporous polysaccharide hemospheres (MPH) has not been studied as a hemostatic agent in this setting.Methods: Prospective, single-blind, randomized controlled trial of patients undergoing fasciocutaneous ALT harvest for head and neck reconstruction at a tertiary academic medical center between April 2018 and February 2020. The intervention (MPH) group received 3 g of topical MPH to the ALT donor site prior to closure whereas the control group did not receive application of MPH. Outcomes included total drain output (ml), drain output during postoperative days (POD) 1-3 alone, drain duration (days), and incidence of donor site hematoma, seroma, or infection.Results: Twenty-nine patients were randomized to the MPH group and 26 to the control group. For MPH and control groups, mean total drain output was 284.7 ± 153.0 ml versus 317.9 ± 177.6 ml (p = .527), mean POD 1-3 drain output alone was 169.3 ± 88.8 ml versus 157.9 ± 78.7 ml (p = .749), and drain duration was 5.9 ± 1.5 days versus 6.5 ± 1.6 days (p = .144), respectively. There was no significant difference in seroma (p = .733), hematoma (p = .492), or infection (p = 1.000). Drain output was not significantly influenced by gender, age, body weight, or smoking habits. Conclusion:MPH administration to ALT free flap donor sites did not significantly improve drain output, hematoma formation, or seroma formation.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%