Utility of line-field confocal optical coherence tomography in the pediatric population

Cappilli, Simone; Guerriero, Cristina; IACOANGELI, Azzurra; Verzì, Anna Elisa; Cinotti, Élisa; Suppa, Mariano; Peris, Ketty; Stefani, Alessandro

doi:10.23736/s2784-8671.23.07634-x

Cited by 4 publications

(5 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By providing a sort of "virtual biopsy", LC-OCT was able to visualize "in vivo" the main features of skin lesions closely resembling a classical histopathologic section, identifying different structures at the epidermis, DEJ, and dermis. Increasing studies in the literature report that a high LCT-OCT/histopathology correspondence of morphological substrates for both epithelial carcinomas (mainly BCC and SCC) and melanocytic lesions improves the meaning and interpretation of LC-OCT features in relation to skin tumours, hence reinforcing the utility of this new diagnostic tool [17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 87%

“…A series of benign and malignant skin vascular lesions have been recently investigated through the use of LC-OCT, resulting in this device being proven useful for the in vivo detection of an increased dermal vascularity with different morphologies in the various entities. Indeed, the correlation of LC-OCT patterns with histological substrates may provide practical clues for the identification of the vascular nature of a lesion and its differential diagnosis [18].…”

Section: Discussionmentioning

confidence: 99%

“…These unprecedented technical characteristics probably explain why LC-OCT has been gaining momentum in the field of dermatological research, as over the last 5 years, numerous publications have seen the light of the day, including a large spectrum of physiological and pathological dermatological conditions. In particular, in the latter group, this tool has been successfully employed to visualize epidermal and upper dermal alterations of tumoral, inflammatory, autoimmune, vascular, and infective conditions and diseases, and also in a pediatric population [17][18][19][20][21][22][23][24][25][26][27][28]. Skin manifestations of rare genetic disorders have also been assessed [26].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Di Stefani,

Cappilli,

Cuffaro

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an unprecedented capacity to acquire high-definition images in vertical and horizontal modes. In this study, we aimed to investigate the LC-OCT morphological features of a series of eyelid skin lesions, correlating them to histopathological findings. Methods: Patients with biopsy-proven equivocal skin lesion in the eyelid area, previously investigated by means of LC-OCT, were included in the study. Percentage overall agreement was estimated for LC-OCT and histopathological diagnosis for study cases. Results: A total of 51 patients (28 women, 23 men; mean age 66.4 years old), for a total of 51 skin lesions, were assessed. The histopathological diagnosis consisted of 30 malignant and 21 benign tumors. Different entities were characterized by peculiar findings in LC-OCT, alike to histopathological features, allowing for an accurate “in vivo” classification in almost all cases, with a diagnostic concordance with histopathology of 92.1% (47/51). Conclusions: By integrating this new imaging technique into the assessment of suspicious tumors in this area, diagnostic accuracy may increase, improving strategies adopted in multidisciplinary meetings and patient-centered care.

show abstract

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Di Stefani,

Cappilli,

Cuffaro

et al. 2023

Diagnostics

View full text Add to dashboard Cite

show abstract

“…Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive technique that provides high-resolution, vertical, and horizontal in vivo images of the skin with a penetration depth of up to 500 µm. [1][2][3][4][5] It also allows visualization of the upper portion of the hair follicle (infundibulum) that contains the hair shaft [Figure 1A,B].LC-OCT has recently been used for the evaluation of some hair diseases, 6-7 and one study only was done on AA for the monitoring of therapeutic response. 8 The aim of this study was to evaluate by LC-OCT the main dermoscopic findings observed in AA and used to enhance the clinical diagnosis, that is, yellow dots, broken hairs, black dots, exclamation mark hairs, and vellus hairs.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Alopecia areata: Line‐field confocal optical coherence tomography features and dermoscopy correlation

Lacarrubba,

Verzì,

Dall'Oglio

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

To the Editor, Alopecia areata (AA) is a common non-scarring disorder characterized by well-circumscribed focal patches of hair loss with an acute or chronic course that can progress to affect all scalp and body hairs. Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive technique that provides high-resolution, vertical, and horizontal in vivo images of the skin with a penetration depth of up to 500 µm. [1][2][3][4][5] It also allows visualization of the upper portion of the hair follicle (infundibulum) that contains the hair shaft [Figure 1A,B].LC-OCT has recently been used for the evaluation of some hair diseases, 6-7 and one study only was done on AA for the monitoring of therapeutic response. 8 The aim of this study was to evaluate by LC-OCT the main dermoscopic findings observed in AA and used to enhance the clinical diagnosis, that is, yellow dots, broken hairs, black dots, exclamation mark hairs, and vellus hairs. 9,10 F I G U R E 1 Normal hair. Vertical (A) and horizontal (B) LC-OCT images show the upper portion of the hair follicle (infundibulum) containing 3 hair shafts (asterisks) with a caliber of 50-60 µm (green bars). The medulla appears high reflective (arrows). Horizontal image (B) is taken at the level of the blue line in A. Insert: dermoscopy of the examined area.

show abstract

Line‐field confocal optical coherence tomography of eyelid margin growths: A case series

Verzì,

Russo,

Castellino

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

BackgroundThe clinical differential diagnosis of lesions arising on the eyelid margin may be challenging and an unneeded surgical approach may have serious functional and aesthetic consequences. Nonetheless, early recognition and treatment of malignant tumors of the eyelid margin is mandatory. Line‐field confocal optical coherence tomography (LC‐OCT) is a novel tool for the in vivo, real‐time skin imaging.ObjectivesThe aim of the study was to identify and analyze the LC‐OCT features of a series of eyelid margin growths and to correlate these features with the histopathological findings.MethodsPatients with eyelid margin growths who were scheduled for lesion excision underwent LC‐OCT examination. Inclusion criteria were a challenging clinical aspect of the lesions and a clinical history of recent onset (up to 12 months). In all cases, the histopathological examination of the excised lesions was performed for the final diagnosis.ResultsA total of 31 lesions located on the upper (13 cases) or lower (18 cases) eyelid margin from 28 consecutive patients (male = 15, female = 13; mean age: 64.7 years, range: 44–87 years) were evaluated and excised. The histopathologic diagnoses were nodular basal cell carcinoma (BCC) (nine cases), squamous cell carcinoma (SCC) (three cases), compound nevus (four cases), dermal nevus (two cases), seborrheic keratosis (four cases), pyogenic granuloma (one case), trichilemmal cyst (three cases), and hidrocystoma (five cases). LC‐OCT allowed the in vivo recognition of the main microscopic features of the examined lesions.ConclusionsLC‐OCT represents a promising tool for the evaluation of eyelid margin lesions. Advantages of non‐invasive diagnosis particularly relevant in such a sensitive region include a more correct planning of the treatment and, in case of surgery, the most appropriate surgical approach and, importantly, a correct timing of intervention.

show abstract

Utility of line-field confocal optical coherence tomography in the pediatric population

Cited by 4 publications

References 37 publications

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Alopecia areata: Line‐field confocal optical coherence tomography features and dermoscopy correlation

Line‐field confocal optical coherence tomography of eyelid margin growths: A case series

Contact Info

Product

Resources

About