Utility of intravoxel incoherent motion MRI derived parameters for prediction of aggressiveness in urothelial bladder carcinoma

Zhang, Miaomiao; Chen, Yan; Cong, Xinying; Zhao, Xinming

doi:10.1002/jmri.26165

Cited by 5 publications

(2 citation statements)

References 27 publications

(52 reference statements)

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“…In terms of the coincidence rate between clinical staging and pathological staging, previous studies have demonstrated that the accuracy of mpMRI for clinical staging of bladder cancer could be as high as 96% [15]. In our center, Zhang et al concluded the diagnostic efficacy of mpMRI and confirmed mpMRI was reliable to predict T staging [27]. In this study, the pathologies of all DR were ≤T1, consistent with the preoperative assessments of cT staging (100%).…”

Section: Discussionsupporting

confidence: 83%

Neoadjuvant Chemotherapy–Guided Bladder-Sparing Treatment for Muscle-Invasive Bladder Cancer: Results of a Pilot Phase II Study

Shi

Zhang

et al. 2021

Cancer Res Treat

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Reduced quality of life after cystectomy has made bladder preservation a popular research topic for muscle-invasive bladder cancer (MIBC). Previous research has indicated significant tumor downstaging after neoadjuvant chemotherapy (NAC). However, maximal transurethral resection of bladder tumor (TURBT) was performed before NAC to define the pathology, impacting the real evaluation of NAC. This research aimed to assess real NAC efficacy without interference from TURBT and apply combined modality therapies guided by NAC efficacy. Materials and Methods Patients with cT2-4aN0M0 MIBC were confirmed by cystoscopic biopsy and imaging. NAC efficacy was assessed by imaging, urine cytology, and cystoscopy with multidisciplinary team discussion. Definite responders (≤T1) underwent TURBT plus concurrent chemoradiotherapy. Incomplete responders underwent radical cystectomy or partial cystectomy if feasible. The primary endpoint was the bladder preservation rate. Results Fifty-nine patients were enrolled, and the median age was 63 years. Patients with cT3-4 accounted for 75%. The median number of NAC cycles was three. Definite responders were 52.5%. The complete response (CR) was 10.2%, and 59.3% of patients received bladdersparing treatments. With a median follow-up of 44.6 months, the 3-year overall survival (OS) was 72.8%. Three-year OS and relapse-free survival were 88.4% and 60.0% in the bladdersparing group but only 74.3% and 37.5% in the cystectomy group. The evaluations of preserved bladder function were satisfactory. Conclusion After stratifying MIBC patients by NAC efficacy, definite responders achieved a satisfactory CANCER RESEARCH AND TREATMENT (CRT) 4

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Section: Discussionsupporting

confidence: 83%

Neoadjuvant Chemotherapy–Guided Bladder-Sparing Treatment for Muscle-Invasive Bladder Cancer: Results of a Pilot Phase II Study

Shi

Zhang

et al. 2021

Cancer Res Treat

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“…Takeuchi et al found that the combined model of T2WI, diffusion-weighted imaging (DWI), and dynamic contrast enhancement (DCE) presented a satisfactory performance with a sensitivity of 90% and a specificity of 88% for evaluating the T stages of BCa (Takeuchi, Sasaki, Ito, Okada, Takahashi, Kawai, Suzuki, Oshima, Hara and Shibamoto 2009). Thoeny, et al (Thoeny, et al 2014) and Zhang, et al (Zhang, et al 2018) noted that various sequences of MRI also performed well in the assessment of aggressiveness and N-stages in BCa. These studies demonstrated the irreplaceable value of MRI in this field.…”

Section: Discussionmentioning

confidence: 96%

Bibliometric analysis of global research trends and hotspots on imaging of bladder cancer

Gong,

Liu,

Zhu

et al. 2023

Preprint

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Purpose To conduct a comprehensive bibliometric analysis of relevant literature on the imaging of BCa and elucidate global research hotspots and further trends in this field. Methods All relevant literature on the imaging of BCa published between January 1, 2000 and July 25, 2023 were retrieved from the Web of Science Core Collection. VOSviewer, Bibliometrix and Citespace were utilized for bibliometric analysis of publications, countries, authors, institutions, journals, references, and keywords. Microsoft Excel was used to draw relevant charts according to the number of publications. Result A total of 4033 articles were retrieved. The research in this field has been increasing consistently since 2000. The USA was the most productive country and most productive institutions were from the USA. Shariat SF was the most productive author with 34 articles and the author with the highest co-citations was Herr HW (418). A study by Siegel RL, published in Ca-Cancer J Clin in 2019, had the highest number of co-citations. Further analysis of the keyword analysis and timeline view revealed that “deep learning”, “MRI”, “VI-RADS”, “muscle-invasive bladder cancer”, “immu-notherapy”, and “lymphatic metastasis” were the most recent hotspots. Conclusion The USA occupies a critical position in this field. The research on imaging of BCa can be classified into two periods: the tumor detection period before 2011 and comprehensive evaluation before treatment decision from 2011 to date. It is anticipated that MRI and deep learning will be the re-search hotspots in this field in the future.

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Role of intravoxel incoherent motion MRI in diagnosis and assessment of invasiveness of urothelial bladder carcinoma

Badawy,

Zaky,

Korkor

et al. 2024

Egypt J Radiol Nucl Med

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Background Urinary bladder cancer is a common malignancy. Preoperative accurate judgment of the degree of tissue invasion is crucial to determine the plan of therapy. We aimed in the current study to evaluate the role of intravoxel incoherent motion (IVIM) MRI and apparent diffusion coefficient (ADC) map in differentiating muscle invasive from non-muscle invasive carcinomas. Results Values of IVIM-derived true diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (F) and ADC were lower in muscle invasive carcinomas than non-invasive masses with p values < 0.001 and 0.001, respectively. In MIBC, ADC was (0.9 × 10−3 mm2/s), D was (0.8 × 10−3 mm2/s), D* was (6.9 × 10−3 mm2/s) and F was (16.9%). In NMIBC, ADC was (1 × 10−3 mm2/s), D was (1.1 × 10−3 mm2/s), D* was (10.2 × 10−3 mm2/s) and F was (17.7%). Mass D cut off values, sensitivity and specificity and AUC were < 0.9, 83.93, 96.30 and 0.945, respectively. Mass ADC cut off values, sensitivity and specificity and AUC were < 1.09, 87.50, 51.85 and 0.721, respectively. The degree of agreement between IVIM parameters and the pathological staging was assessed by Kappa test. The best agreement was detected for mass D (K = 0.796), while the mass ADC and wall beside mass D showed moderate and fair agreement (k = 0.418 and 0.325, respectively). Conclusions IVIM MRI parameters and ADC map can be utilized to detect the degree of tissue invasion caused by bladder cancer.

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Utility of intravoxel incoherent motion MRI derived parameters for prediction of aggressiveness in urothelial bladder carcinoma

Abstract: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1648-1656.

Cited by 5 publications

References 27 publications

Neoadjuvant Chemotherapy–Guided Bladder-Sparing Treatment for Muscle-Invasive Bladder Cancer: Results of a Pilot Phase II Study

Neoadjuvant Chemotherapy–Guided Bladder-Sparing Treatment for Muscle-Invasive Bladder Cancer: Results of a Pilot Phase II Study

Bibliometric analysis of global research trends and hotspots on imaging of bladder cancer

Role of intravoxel incoherent motion MRI in diagnosis and assessment of invasiveness of urothelial bladder carcinoma

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