Utility of intrastriatal ratios of FDOPA to differentiate idiopathic Parkinson’s disease from atypical parkinsonian disorders

Abstract

The SOR method is already known to be a good diagnostic tool to differentiate between IPD patients and the normal population. SOR, however, fails to distinguish IPD from APD patients, and hence the RSOR of the caudate and posterior putamen can be utilized to differentiate between them.

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

“…In an effort to examine the potential role of Mn in idiopathic PD, a recent study used [ 18 F]-Fluoro-L-Dopa Positron Emission Tomography ([ 18 F]-FDOPA PET) imaging on 20 asymptomatic welders (exposed to welding fumes containing Mn), 20 subjects with idiopathic PD and 20 normal controls (Criswell et al, 2011). [ 18 F]-FDOPA PET is a non-invasive neuroimaging method to assess presynaptic dopamine terminal activity in vivo and has been used in idiopathic PD patients as a marker of dopamine terminal integrity (Gallagher et al, 2011; Jaimini et al, 2013). Notably, [ 18 F]-FDOPA uptake is dramatically decreased with a distinct regional pattern in the caudate and putamen of idiopathic PD patients (Morrish et al, 1996; Nurmi et al, 2001; Hilker et al, 2005; Gallagher et al, 2011).…”

Orbitofrontal18F-DOPA Uptake and Movement Preparation in Parkinson’s Disease

“…Moreover, normalized uptake values on reference regions tightly correlate with kinetic parameters [ 15 ] and have similar diagnostic accuracy in PD as kinetic parameters [ 15 , 17 , 18 ]. Also, in PD similar diagnostic accuracy for occipital-normalized 18 F-DOPA uptake as 123 I-FP-CIT SPECT has been demonstrated [ 19 – 21 ]. The PET scan was performed within one month from the motor task.…”

“…Different modeling approaches have been proposed and still research and discussion are open on these issues [ 16 ]. Meanwhile, static acquisition with normalization of uptake values on a reference region (cerebellum or occipital lobe) has been validated as a simpler and suitable approach for both research and clinical purposes [ 15 , 17 ] and has been increasingly used in studies of Parkinsonian patients [ 18 , 19 ]. Moreover, normalized uptake values on reference regions tightly correlate with kinetic parameters [ 15 ] and have similar diagnostic accuracy in PD as kinetic parameters [ 15 , 17 , 18 ].…”

Biomarker selection and imaging design in cancer: A link with biochemical pathways for imminent engineering

“…It has diversified clinical application due to its longer half-life [78,79]. It's mainly detected in the substantianigra, caudatum and putamen nuclei of brain, complementary in structures and have a trivial embryologic origin [80].18F-DOPA is a prevalent biomarker proposed for the diagnosis of primary brain lesions, particularly of its high uptake in tumors in contrast to its minute uptake in normal brain tissues, other than basal ganglia [81]. Experimentally its proved that 18 F-FDOPA is superior to 18F-FDG in case of recurrent low grade gliomas even using MRI [82].…”