Utility of Immunohistochemistry in the Diagnosis of a Case of Hepatic Angiomyolipoma from a Tertiary Referral Centre for Liver Diseases

Abstract

A single case of hepatic Angiomyolipoma (AML) over 25 years in a tertiary referral center for liver diseases is being presented. A 56-year old gentleman presented with abdominal pain, fullness and weight loss. A large left lobe mass in a background of non-cirrhotic liver was radiologically inscribed. The risk of rupture of together with the possibility of malignancy seedlings were the restraints against CT guided liver biopsy. Left lateral segmentectomy was the consulting surgical team's decisive maneuver. Gross pathological examination, histological evaluation and immunohistochemical analysis were performed to determine the nature of tumor. Results revealed normal serum levels of alpha-fetoprotein, CA 19.9 and carcinoembryonic antigen. Grossly the tumor exhibited variable consistency. Histologically, the tumor displayed three main constituents intermingled together; blood vessels, myoid cells and fat. Immunohistochemistry revealed positive immune reaction for CD34, alpha smooth muscle actin and S-100 in tumor tissue but negative for anti-human hepatocyte antibody.