Utility of hyposmia and hypogeusia for the diagnosis of COVID-19

Bénézit, François; Turnier, Paul Le; Declerck, Charlotte; Paillé, Cécile; Revest, Matthieu; Dubée, Vincent; Tattevin, Pierre; Arvieux, Cédric; Baldeyrou, M.; Chapplain, Jean Marc; Comacle, Pauline; Patrat-Delon, Solène; Maillard, Anne; Poinot, M; Pronier, Charlotte; Souala, Faouzi; Thibault, Vincent; Abgueguen, P.; Cormier, H.; Delbos, V.; Chapelle, M. de la; Ducancelle, Alexandra; Mahieu, Rafaël; Rabier, V.; Rehaiem, Sami; Vandamme, Yves Marie; Biron, Charlotte; Brochon, Jeanne; Boutoille, David; Chauveau, Marie; Deschanvres, Colin; Gaborit, Benjamin; Jenvrin, J.; Lecomte, R.; Lefèbvre, M.; Raffi, François

doi:10.1016/s1473-3099(20)30297-8

Cited by 209 publications

(247 citation statements)

References 4 publications

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“…Several other authors have recently published similar results, particularly on European outpatient populations. [13][14][15]18,21] SARS-CoV-2 has been shown to have a particular tropism for the nerves of the ear, nose and throat system. [22] This is probably the reason why the proportion of patients with taste and smell disorders is higher in COVID-19 patients than in patients with other respiratory tract infections.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

Sebo

Tudrej

Lourdaux³

et al. 2020

Preprint

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Background: The early identification of patients suffering from SARS-CoV-2 infection in primary care is of outmost importance in the current pandemic.Aim: To gain a better understanding of the specific symptoms of SARS-CoV-2 infection in primary care.Design and setting: We conducted a cross-sectional study between March 24 and May 7, 2020, involving consecutive patients undergoing RT-PCR testing in two community-based laboratories in Lyon (France) for a suspicion of COVID-19.Methods: We examined the association between various symptoms and a positive test using univariate and multivariate logistic regression, adjusted for clustering within the laboratories.Results: Of the 1561 patients tested, 1543 agreed to participate (participation rate: 99%). Among them, 253 were positive for SARS-Cov-2 (16%). In multivariate analysis, loss of taste (OR 3.8 [95%CI 3.3-4.4], p-value<0.001), loss of smell (OR 3.0 [95%CI 1.9-4.8], p-value<0.001), muscle pain (OR 1.6 [95%CI 1.2-2.0], p-value 0.001) and dry nose (OR 1.3 [95%CI 1.1-1.6], p-value 0.01) were significantly associated with a positive result. The strength of association with taste and smell disorders was higher for symptom combinations (OR 6.5 [95%CI 3.9-10.8] for loss of taste and smell, OR 6.7 [95%CI 5.9-7.5] for loss of taste or smell). In contrast, sore throat (OR 0.6 [95%CI 0.4-0.8], p-value 0.003), stuffy nose (OR 0.7 [95%CI 0.6-0.7], p-value<0.001), diarrhea (OR 0.6 [95%CI 0.5-0.6], p-value<0.001) and dyspnea (OR 0.5 [95%CI 0.3-0.7], p-value<0.001) were inversely associated with a positive test.Conclusion: Our data could further facilitate targeted screening and contribute to the triage and early identification of new clusters of cases.

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Section: Comparison With Existing Literaturementioning

confidence: 99%

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

Sebo

Tudrej

Lourdaux³

et al. 2020

Preprint

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“…The included studies consist of a variety of study designs -cross-sectional (n = 22) (12,(16)(17)(18)(19)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41); case-control (n = 3) (42-44); casereport and case series (n = 3) studies (45)(46)(47). Two categories of the MMAT were employed based on the study design to examine the methodological quality of these studies; quantitative non-randomized category for cross-sectional and case-control studies and quantitative descriptive category for case-report and case series ones.…”

Section: Quality Assessmentmentioning

confidence: 99%

“…The most common method was the self-report. Self-report could be done through different ways: an online questionnaire (12,19,27,30,34,37), non-online questionnaire (18,32,35,39,43,44), online checklist (17), the COVID RADAR Symptom Tracker app (16), visual analogue scale (VAS) (25), archived medical records (40,41), or verbally (45,46). Four studies (28,29,31,33) did not report how to measure, just extracted from medical records.…”

Section: Olfactory and Gustatory Dysfunction Measurementmentioning

confidence: 99%

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

Esmaeili

Abdi

Shafiee

et al. 2020

Preprint

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BackgroundEvidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. MethodsIn this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6th May 2020. Afterward, all studies reported the taste and smell dysfunction in the COVID-19 patients were included. The quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). The pooled prevalence of olfactory and gustatory dysfunction was estimated using the random effects meta-analysis method.ResultsAmong 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. ConclusionOlfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.

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“…Smell loss (anosmia), and to a lesser degree taste loss (ageusia), accompanying COVID-19 infection have appeared in reports of COVID-19 patients' testimonies 1 , preprints of scientific papers [2][3][4] , peer-reviewed publications (e.g. [5][6][7][8][9] ), and are being widely discussed by journalists.…”

Section: Introductionmentioning

confidence: 99%

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

Asseo

Fierro

Slavutsky

et al. 2020

Preprint

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Web tools are widely used among population to obtain health related information, and these data are often employed for public health monitoring. Here we analyzed searches related to smell loss and taste loss, recently linked to COVID-19, as well as sight loss and hearing loss, not included in the COVID-19 symptoms list. Google Trends results per region (Italy) or state (United States) over several weeks were compared to the number of new cases prevalence in that geographical area. Taste and smell loss searches were correlated with each other, and, during a limited time window, with new COVID-19 cases. However, this correlation decreased with time, attributable, at least in part, to media coverage. As new symptoms are being discovered for COVID-19 and the pandemic continues to spread around the globe, the lesson learned here, that correlation between public interest in novel symptoms of infectious disease has an initial spike (the "surprise rise") and subsequently goes to a new baseline due to "knowledge saturation", is of general and practical value for the public.Supplementary Figure S1 repeats the calculation presented in Figure 1 for the 22-28 April week. This clearly illustrates the current lack of correlation between the number of new cases in each region (Italy) or state (US) and the popularity of Google searches on either taste or smell loss.

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Utility of hyposmia and hypogeusia for the diagnosis of COVID-19

Cited by 209 publications

References 4 publications

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

Clinical characteristics of SARS-CoV-2 patients: a French cross-sectional study in primary care

Olfactory and gustatory dysfunction in 2019 novel coronavirus: An updated systematic review and meta-analysis

Utility and limitations of Google searches on sensory loss as markers for new COVID-19 cases

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