Utility of Human Papillomavirus Testing for Cervical Cancer Screening in Korea

Kim, Mee-Seon; Lee, Eun Hee; Park, Moon-il; Lee, Jae Seok; Kim, Ki-Su; Roh, Mee Sook; Lee, Hyoun Wook

doi:10.3390/ijerph17051726

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…Onclarity is an FDA-approved HPV genotyping test widely used for cervical cancer screening including several major hospitals at South Korea [29]. It can detect 14 hrHPV genotypes (HPV 16, 18, 31, 45, 51, 52, 33/ 58, 56/59/66, and 35/39/68).…”

Section: Plos Onementioning

confidence: 99%

Comparison of Seegene Anyplex II HPV28 assay with BD Onclarity HPV assay for human papillomavirus genotyping

Kim

Park

et al. 2022

PLoS ONE

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Presently, human papillomavirus (HPV)-based cervical cancer screening is commonly used and is replacing conventional cytology screening tests. The HPV genotyping assay is useful for triage in cervical cancer screening and the evaluation of HPV vaccination effects. In this study, we evaluated the clinical performance of two HPV genotyping assays, BD Onclarity HPV (Onclarity) and Seegene Anyplex II HPV28 (Anyplex) in the detection of relevant cervical lesions and for HPV genotyping concordance. Anyplex and Onclarity assays were performed on 920 consecutive liquid-based specimens. Anyplex, sensitivity, specificity, and genotyping concordance with Onclarity were optimal when restricted to ≥2+ (medium) viral loads. HPV genotyping agreement between the two assays ranged between 0.75 and 0.9 (excellent), except for HPV 33/58, which was 0.73 (good). With Onclarity as a reference, the relative sensitivity of Anyplex for the detection of ≥CIN 2 was 1.05 (95% CI: 0.99–1.1) and the relative specificity for detection of negative for intraepithelial lesion and malignancy (NILM) was 0.89 (95% CI: 0.85–0.93). For most ≥CIN 2 lesions, high-risk HPV was detected by Onclarity (66/72) and Anyplex (69/72) assays. For high-risk HPV negative ≥CIN 2 lesions, possible high-risk HPV genotypes were detected by Anyplex. In conclusion, the genotyping agreement between the tests was good to excellent. Full genotyping with Anyplex might confer additional benefits to patients with ≥CIN 2, although the difference is small. We also suggest an optimal cutoff value when reporting HPV infections using the Anyplex assay (≥2+; medium viral loads).

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Section: Plos Onementioning

confidence: 99%

Comparison of Seegene Anyplex II HPV28 assay with BD Onclarity HPV assay for human papillomavirus genotyping

Kim

Park

et al. 2022

PLoS ONE

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“…It has been reported to show the strong correlation between chronic inflammation caused by infections or autoimmune diseases and cancers [73]. For example, hepatitis B virus infection may increase the risk of hepatocellular carcinoma [74,75], and high-risky types of Human papillomavirus (HPV) infection are associated with an increased risk of cervical cancer [76,77]. Patients with autoimmune diseases also have a higher incidence of malignancies, such as scleroderma and myositis [73].…”

Section: Prostaglandin Related Genesmentioning

confidence: 99%

“…Ganitumab, a human monoclonal antibody to IGF-1R can enhance the therapeutic effect of platinum-based chemotherapy passing through the inhibition of the IGF-2-dependent tumor growth [101]. However, the blocking of IGF-1R cannot counteract paclitaxel resistance [76], suggesting that the development of chemo-resistance of cisplatin and paclitaxel may involve the different mechanisms. PI3K/Akt/mTOR is often activated in malignancies, and the Ras/Raf/MEK/ERK signaling pathway is enhanced in pancreatic cancer [102], colon cancer [103], and thyroid cancer [104].…”

Section: Insulin-like Growth Factor Related Genesmentioning

confidence: 99%

Functional Gene Clusters in Global Pathogenesis of Clear Cell Carcinoma of the Ovary Discovered by Integrated Analysis of Transcriptomes

Hsu

Wang

2020

IJERPH

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Clear cell carcinoma of the ovary (ovarian clear cell carcinoma (OCCC)) is one epithelial ovarian carcinoma that is known to have a poor prognosis and a tendency for being refractory to treatment due to unclear pathogenesis. Published investigations of OCCC have mainly focused only on individual genes and lack of systematic integrated research to analyze the pathogenesis of OCCC in a genome-wide perspective. Thus, we conducted an integrated analysis using transcriptome datasets from a public domain database to determine genes that may be implicated in the pathogenesis involved in OCCC carcinogenesis. We used the data obtained from the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) DataSets. We found six interactive functional gene clusters in the pathogenesis network of OCCC, including ribosomal protein, eukaryotic translation initiation factors, lactate, prostaglandin, proteasome, and insulin-like growth factor. This finding from our integrated analysis affords us a global understanding of the interactive network of OCCC pathogenesis.

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“…However, only ~20 HPV genotypes are commonly encountered in anogenital lesions. Currently, 12 HPV genotypes, i.e., HPV 16,18,31,33,35,39,45,51,52,56,58, and 59, are classified as group 1 carcinogens by the International Agency for Research on Cancer [7]. Although HPV 16 and 18 are the predominant causative agents of cervical cancer and their precursor lesions, other high-risk HPVs are also associated with significant oncogenic risk [8].…”

mentioning

confidence: 99%

“…BD Onclarity HPV assay, an U.S. Food and Drug Administration–approved HPV screening test, is a semi-quantitative real-time polymerase chain reaction–based test that can simultaneously detect multiple HPV genotypes, including HPV 16, 18, 31, 45, 51, 52, 33/35, 56/59/66, and 35/39/68 [ 17 ]. It is widely used in many hospitals in Korea [ 18 ]. In this study, we have investigated the clinicopathological aspects of multiple HPV infections using the BD Onclarity HPV assay.…”

mentioning

confidence: 99%

Evaluation of the characteristics of multiple human papillomavirus (HPV) infections identified using the BD Onclarity HPV assay and comparison with those of single HPV infection

Kim

Park

2022

JPTM

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Background: Human papillomavirus (HPV) infection is a major cause of cervical cancer and associated precursor lesions. Multiple HPV genotype infections have been reported. However, their clinicopathological characteristics still remain elusive.Methods: For this study, 814 consecutive patients who had undergone colposcopy and HPV genotyping test using BD Onclarity HPV assay were retrospectively selected. Clinicopathological parameters of multiple HPV infections were compared with those of single HPV infection.Results: Multiple HPV infections were found in 110 out of 814 cases (13.5%). Multiple HPV infections were associated with a significantly higher incidence of high-grade intraepithelial lesions (HSILs) compared with single HPV infection. Other high-risk HPV genotypes, in addition to HPV 16, were found more frequently in the multiple HPV infections group; these included HPV 51, 52, 33/58, 56/59/66, and 35/39/68. No specific coinfection pattern was not identified. Additionally, the number of HPV genotypes in multiple HPV infections was not associated with the progression to HSIL or squamous cell carcinoma.Conclusions: Multiple HPV infections have distinct clinicopathological characteristics (compared with single HPV infection). As their biological behavior is uncertain, close and frequent follow-up is warranted.

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Utility of Human Papillomavirus Testing for Cervical Cancer Screening in Korea

Cited by 5 publications

References 24 publications

Comparison of Seegene Anyplex II HPV28 assay with BD Onclarity HPV assay for human papillomavirus genotyping

Comparison of Seegene Anyplex II HPV28 assay with BD Onclarity HPV assay for human papillomavirus genotyping

Functional Gene Clusters in Global Pathogenesis of Clear Cell Carcinoma of the Ovary Discovered by Integrated Analysis of Transcriptomes

Evaluation of the characteristics of multiple human papillomavirus (HPV) infections identified using the BD Onclarity HPV assay and comparison with those of single HPV infection

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