Utility of human amniotic membrane allograft in re-epithelialization of the nasal tip

Dennis, D'Antonio C.; Turnock, Adam R.; Sutton, Collin; Chastant, Bradley; Vanderlan, Wesley B.

doi:10.1093/jscr/rjw174

Cited by 2 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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“…24 Some studies presented dehydrated HAM provides an alternative to local tissue transfer and skin grafting for traumatic injuries involving the nose. 25 , 26…”

Section: Discussionmentioning

confidence: 99%

Effects of the Human Amniotic Membrane on the Cartilage Graft: Prognosis and Absorption in White Rabbits

Motamed

Torbati

Arani

et al. 2019

wjps

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BACKGROUND Cartilage grafts are generally accepted for the restoration and reconstruction of nasal contours. The main concern that plastic surgeons may need to address after surgery pertains to the resorption and disfigurement of the grafted cartilage, especially in allogenic and heterogenic grafts. METHODS A total of 12 white rabbits were divided into three groups according to the types of graft including autograft, allograft, and heterograft. We used three shapes of grafts, including block, crushed, and diced cartilage in the upper, middle, and lower rows. However, in each rabbit, these grafts were divided into two columns of wrapped and unwrapped grafts, with human amniotic membrane (HAM) grafted on each side of the rabbit’s back. RESULTS In total, 60 specimens underwent histopathological examination. No inflammation was observed in about 50% of the block-shaped conchal cartilages with HAM, and in 50%, less than 25 inflammatory cells per unit were seen. The prognosis and absorption of autograft specimens in block-shaped cartilages with HAM were significantly better compared with other shapes of cartilages with HAM and without HAM. The proliferation rate of fibroblasts in autograft and allograft specimens was more than that in heterograft specimens with HAM. CONCLUSION Our findings have demonstrated the new role of HAM in clinical applications, indicating that HAM may be used as a low-cost, easily accessible alternative for wrapping in cartilage grafts instead of fascia or surgicel in early future. It is useful for improving the long-term outcomes and decreasing the resorption rate.

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“…24 Some studies presented dehydrated HAM provides an alternative to local tissue transfer and skin grafting for traumatic injuries involving the nose. 25 , 26…”

Section: Discussionmentioning

confidence: 99%

Effects of the Human Amniotic Membrane on the Cartilage Graft: Prognosis and Absorption in White Rabbits

Motamed

Torbati

Arani

et al. 2019

wjps

View full text Add to dashboard Cite

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“…The above findings in animals suggest encouraging outcomes of HAAM for the lower third nasal reconstruction in humans in this study. Although the dehydrated AM has been reported to treat traumatic wounds to the nasal tip in one case [16], our study is the first randomised controlled trial to investigate the feasibility of HAAM in the treatment of circular skin defects for nasal reconstruction and to demonstrate excellent healing with minimal aesthetic impact.…”

Section: Discussionmentioning

confidence: 99%

“…Human AM also prevents infection and accelerates healing in the treatment of chronic ulcers [8, 9], necrotising fasciitis [10], epidermolysis bullosa [11] and other cutaneous diseases [12]. Similar outcomes were determined after the human AM was dehydrated or freeze-dried [13–16].…”

Section: Introductionmentioning

confidence: 98%

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing

Xue

Li²,

Parolini

et al. 2018

Burns &Amp; Trauma

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BackgroundThe lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans.MethodsIn this study, 180 patients who underwent excision of skin lesions of the lower third of the nose from 2012 to 2016 were included; of the patients, 92 received HAAM and Vaseline gauze treatments, and the other 88 patients received Vaseline gauze treatment only. The haemostasis time and the duration of operation were recorded during surgery; after surgery, the time to pain disappearance, scab formation and wound healing, and the wound healing rate were measured.ResultsImmediately after the HAAM implantation, a reduction of the haemostasis time and an accelerated disappearance of pain were observed. Compared with the control group, the formation and detachment of scab in patients who received the HAAM implantation were notably accelerated, postoperatively. When the diameter of the lesion exceeded 5 mm, the HAAM implantation was found to enhance the wound healing, although this enhancement was not seen when the diameter was less than 5 mm. Additionally, the HAAM implantation significantly reduced bleeding, wound infection and scar formation, postoperatively.ConclusionsHAAM-assisted healing is a promising therapy for lower third nasal reconstruction leading to rapid wound healing and fewer complications and thus has considerable potential for extensive clinical application in repairing skin wounds.Trial registrationChiCTR1800017618, retrospectively registered on July 08, 2018.

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Utility of human amniotic membrane allograft in re-epithelialization of the nasal tip

Cited by 2 publications

References 10 publications

Effects of the Human Amniotic Membrane on the Cartilage Graft: Prognosis and Absorption in White Rabbits

Effects of the Human Amniotic Membrane on the Cartilage Graft: Prognosis and Absorption in White Rabbits

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing

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