Utility of Histochemical and Immunohistochemical Profile in Grading of Squamous Cell Carcinoma of the Oral Cavity

Jagtap, Miheer; Shukla, Samarth; Acharya, Sourya; Tamhane, Ankita; Bhake, Arvind

doi:10.7860/jcdr/2020/42221.13396

Cited by 5 publications

(5 citation statements)

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“…Increased AgNORs count associated with short DFS and poor OS. This finding was in keeping with several studies done by Jagtap et al, 2020;Mohanty et al, 2020;Jagtap et al, 2020;Mohanty et al, 2020). However, Gundog et al (2016) found an inverse correlation between AgNORs count, OS, and DFS in rectal cancer (Gundog et al, 2015).…”

Section: Author Contribution Statementsupporting

confidence: 87%

“…Evaluation of the AgNORs count aids in investigating the rate of cellular proliferation and predicting tumor aggressiveness. The black dots of AgNORs were more significant in number and more irregular in shape in malignant lesions (Jagtap et al, 2020). The AgNORs are generally considered to be proliferation markers.…”

Section: Discussionmentioning

confidence: 94%

“…The AgNORs technique is a good indicator of cell activity, nevertheless, it should not be applied to differentiate between benign and malignant epithelial tumors (Mohamed Mahmoud et al, 2017). In oral squamous cell carcinoma (OSCC), AgNOR is a supportive guide for the clinician and the histopathologist predicting the proliferation rate, in addition to understanding the biological behavior of OSCC (Jagtap MM et al, 2020). Moreover, a previous study suggested that AgNOR mirrors the metabolic activity changes in the cells, which can applied aid in the differentiation between various salivary gland tumors (SGTs) (Gupta et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Could Argyrophilic Nucleolar Organizer Regions count mirror DNA Ploidy in Malignant Salivary Gland Tumors?

Hussien

Mohamed

Mansor

et al. 2022

Asian Pac J Cancer Prev

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Objective: Nucleolar organizer regions (NORs) are DNA coils that transcribe to ribosomal RNA. The NORassociated protein, termed argyrophilic NOR (AgNOR), was visible within the nucleus by staining with silver nitrate examination via the light microscope. AgNOR counting is a proliferation marker and may help in the diagnosis and prognosis of various neoplastic lesions. Aneuploidy (abnormal DNA content) can predict the progression, survival and prognosis of the tumors. The aim of this study was to evaluate the role of AgNORs, DNA ploidy status, and total S-phase fraction (TSPF) as prognostic parameters in malignant salivary gland tumors (MSGTs). Methods: The current study is a retrospective study on a cohort of MSGTs (N=47), to assess AgNORs using Silver Nitrate stain, DNA index (DI), and TSPF using flow cytometry (FCM). Data including tumor size and site, lymphovascular invasion (LVI), lymph node metastasis (LNM) were collected. Results: The AgNORs count was statistically significant with MSGT type. DI was found to have a significant association with tumor site, tumor size and MSGT type. In addition, TSPF was found to be significantly associated with LVI. A moderate positive correlation was noted between AgNORs count and TSPF. LNM, tumor site, high AgNORs and low DI were all associated with short disease-free survival (DFS) and poor overall survival (OS). Conclusion: The present study revealed that high AgNORs count, DNA aneuploidy and TSPF had a poor influence on MSGTs prognosis.

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Section: Author Contribution Statementsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Could Argyrophilic Nucleolar Organizer Regions count mirror DNA Ploidy in Malignant Salivary Gland Tumors?

Hussien

Mohamed

Mansor

et al. 2022

Asian Pac J Cancer Prev

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“…If the neoplasm is small and localized then the 5-year survival rate is said to be 60-70%; whereas in case of cervical nodal metastasis, the survival rate is only around 25%. 9 So, the most important prognostic indicator is the clinical stage of disease. Gingival squamous cell carcinoma shows cervical metastasis is more than one third of the cases, so early diagnosis is a key factor in the treatment of SCC.…”

Section: Discussionmentioning

confidence: 99%

Rare presentation of gingival squamous cell carcinoma of maxillary posterior region mimicking pyogenic granuloma in a non-smoker – A case report

Kadhiresan¹,

Reshmaa

Arunmozhi³

et al. 2021

IJPI

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Gingival Squamous cell carcinoma (GSCC) in maxilla is a rare malignant neoplasm especially when compared with mandible. The most common sites of oral carcinoma are being the lateral border of the tongue and the floor of the mouth which is followed by palate, buccal mucosa and rarely in gingiva. The clinical picture of oral carcinoma can be misguided for gingival overgrowth, desquamative lesions, traumatic ulcers or even pyogenic granuloma. Maxillary oral gingival carcinoma is a rare entity especially in a non-smoker. In this case report, a 70-year-old male patient presented with a gingival lesion in maxilla 24,25 region mimicking pyogenic granuloma without having a tobacco history. A thorough clinical, radiographical and histopathological examination was done and led to the diagnosis of GSCC and the treatment was initiated.Creating awareness among practitioners about gingival squamous cell carcinoma mimicking pyogenic granuloma in dental practice.

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“…Cervical lymph node lesions vary in nature and have a malignancy rate of more than 50%. Metastatic carcinoma and lymphoma are the most common cervical malignant lesions, with cervical lymph node metastatic carcinoma accounting for around 3/4 of all malignant neck lesions [ 2 ]. The majority of cervical malignant lesions (85%) are primary head and neck lesions, with thyroid carcinoma (TC), salivary gland carcinoma (SC), and squamous cell carcinoma (SCC) being the most common nodal metastases [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Management and Prognosis of Physical Therapy for the Post-Surgical Sequelae of Metastatic Cervical Lymphadenopathy

Saifee¹,

Patil²,

Thorat³

et al. 2022

Cureus

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A common secondary complication of oral malignant carcinoma is metastatic cervical lymphadenopathy. The condition is typically treated surgically, with the affected cervical lymph nodes excised, followed by pharmacological treatment. However, additional complications such as asymmetry of facial features, reduced mouth opening, adhesions in sutured tissues, and so on accompany surgical management. This case report describes a case of an adult male who underwent surgery for metastatic cervical lymphadenopathy caused by previous squamous cell carcinoma of buccal mucosa. To address the surgical outcomes that were affecting the patient's quality of life, an integrated physiotherapy management protocol was developed and efficiently followed for three weeks. Improvements in mouth opening, tongue movement, cervical joint movement, chest movement, and the Oral Health Impact Profile quality of life questionnaire were observed at the three-week evaluation, indicating that the intended therapy was effective.

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Utility of Histochemical and Immunohistochemical Profile in Grading of Squamous Cell Carcinoma of the Oral Cavity

Cited by 5 publications

References 0 publications

Could Argyrophilic Nucleolar Organizer Regions count mirror DNA Ploidy in Malignant Salivary Gland Tumors?

Could Argyrophilic Nucleolar Organizer Regions count mirror DNA Ploidy in Malignant Salivary Gland Tumors?

Rare presentation of gingival squamous cell carcinoma of maxillary posterior region mimicking pyogenic granuloma in a non-smoker – A case report

Management and Prognosis of Physical Therapy for the Post-Surgical Sequelae of Metastatic Cervical Lymphadenopathy

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