Utility of Hantzsch Ester in Synthesis of Some 3,5‐Bis‐dihydropyridine Derivatives and Studying Their Biological Evaluation

Abstract

The present work involves synthesis of new 3,5‐bis‐substituted dihydropyridine derivatives 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 starting from dihydropyridine‐3,5‐dicarboxylate (1) as starting material. Structures of new compounds were established by spectral and elemental analyses. Some of the new compounds were evaluated for anticancer and antimicrobial activity. Screening data of the tested compounds show promising anticancer and antimicrobial activity. The detail synthesis, spectroscopic data, and pharmacological activities are reported.

Synthesis and Antimicrobial Activity of 1,3,4-Oxadiazoline, 1,3-Thiazolidine, and 1,2,4-Triazoline Double-Tailed Acyclo C-Nucleosides

“…On the other hand, in the recent 2 decades, significant growth in scientific publications dealing with the synthesis of numerous acyclo C-nucleosides analogues, especially after many the members showed diverse biological activities. Furthermore, several modifications have been made at the molecular structural level of acyclo C-nucleosides including a number of nucleobase − (head) and alditolyl chains , (tail). Among the structurally modified acyclo C-nucleosides, there are double-tailed acyclo C-nucleosides and a unique structural feature is the presence of two carbon-linked alditolyl chains of one or two of identical nucleobases or more of different nucleobase.…”

Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives

“…Pyridine derivatives have received great attention because of their presence in various drugs and biologically active molecules [ 1 , 2 , 3 , 4 ]. In our previous work, we found that heterocyclic compounds implicate the pyridine nucleus and showed wide promising biological activities such as anti-cancer [ 5 , 6 , 7 ], anti-oxidant [ 8 , 9 ], anti-microbial [ 5 , 9 , 10 ] and anti-viral [ 2 ] activities. In addition, the literature reports that pyridine derivatives are potent anti-inflammatory [ 11 , 12 , 13 , 14 ], Ca 2+ channel antagonists [ 15 ], anti-cancer [ 16 , 17 , 18 ], anti-plasmodial [ 19 ], anti-microbial [ 20 , 21 ], anti-malarial [ 22 ] anti-biotic [ 23 ], analgesic [ 24 , 25 ], anti-oxidant [ 26 ] agents.…”

Synthesis and anticancer activity of novel 2-substituted pyranopyridine derivatives

“…It constitutes the basic core in many products such as drugs, vitamins and food. Literature survey indicates that a large number of pyridine derivatives are associated with diverse pharmacological properties, such as antimicrobial [1][2][3], antiviral [4], antifungal and antimycobacterial [5], anticancer [6], sodium channel modulation [7][8][9][10][11][12] and anticonvulsant [13] activities. Also, the naturally occurring B6-vitamins pyridoxine, pyrodoxal, pyridoxamine and codecarboxylase contain a pyridine nucleus [14].…”

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A novel series of 2-aminopyranopyridine derivatives (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were synthesized utilizing 2-chloro-4-(thiophen-2-yl)-7,8-dihydro-5H-pyrano[4,3-b]pyridine-3-carbonitrile (2) as a key starting compound. The structures of the newly synthesized compounds were confirmed on the basis of elemental analyses and infrared (IR), 1 H, 13 C-nuclear magnetic resonance (NMR) and mass spectra.

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