Utility of glomerular morphometry in diagnosing pediatric renal disease

Kashif, A W; Verma, Nisha; Verma, Shipra; Boruah, Dibyajyoti; Sahu, Rajesh; Kalra, Suprita; Malik, Ajay

doi:10.1016/j.mjafi.2020.08.007

Cited by 5 publications

(1 citation statement)

References 17 publications

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“…After measuring, Bowman's space percentage was calculated via a formula given below. Changes in the % Bowman's space area were statistically analyzed and compared among the experimental groups (Kashif et al, 2021).…”

Section: Calculation Of Bowman's Space Percentagementioning

confidence: 99%

Melatonin mitigates cisplatin-induced acute kidney injury through regulation of the heat shock proteins expressions

Akın

Unsal

Ceylan

et al. 2021

Preprint

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Purpose. To determine the protective effects of melatonin (MEL) in acute kidney injury (AKI) induced by Cisplatin (CP), widely used as a chemotherapeutic in the treatment of many cancer types, via assessment of heat-shock proteins (HSPs) levels in rats. Methods. Total 40 Wistar albino rats were divided into four groups: Control (n = 10), MEL (n = 10, 10 mg/kg/i.p melatonin for 8 days), CP (n = 10, 7 mg/kg/i.p cisplatin at the 5th day), and CP + MEL (n = 10, 10 mg/kg/i.p melatonin for 8 days and 7 mg/kg/i.p cisplatin at the 5th day). After administrations, animals were sacrificed, and kidney tissues were extracted. Histopathological changes were evaluated and glomerular and tubular immunoreactivities of HSP47, HSP60, HSP7, and HSP90 in renal cortex were detected by immunohistochemistry. Moreover, blood serum BUN, creatinine and uric acid levels were measured to assess of kidney function. Results. CP group showed histopathological deterioration compared to Control group and MEL treatment attenuated this damage. When compared with Control and MEL groups, an increase in HSPs immunoreactivities in renal cortex and blood serum BUN, creatinine and uric acid levels were observed in the CP group. Furthermore, an improvement was observed in the CP + MEL in terms of these parameters compared to the CP group. Conclusion. According to our results, MEL could exert a significant protective effect to ameliorate CP-induced AKI via regulation of heat-shock protein expressions.

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Section: Calculation Of Bowman's Space Percentagementioning

confidence: 99%

Melatonin mitigates cisplatin-induced acute kidney injury through regulation of the heat shock proteins expressions

Akın

Unsal

Ceylan

et al. 2021

Preprint

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Do extraglomerular microvasculature and mesenchymal interstitial cell proliferation indicate a stable course of lupus nephritis?

Tripathi¹,

Kashif²,

Malik³

et al. 2022

Medical Journal Armed Forces India

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The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats

Abdelhady,

Ali,

Yacout

et al. 2023

Sci Rep

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Although nonsteroidal antiinflammatory drugs (NSAIDs) are frequently used for fever and pain during pregnancy, their possible interaction with perinatal renal injury induced by preeclampsia (PE) has not been addressed. Here, studies were undertaken in the N(gamma)-nitro-l-arginine methyl ester (l-NAME) PE model to assess the influence of gestational NSAIDs on renal damage in weaning dams. PE-evoked increments and decrements in urine protein and creatinine clearance, respectively, were intensified by celecoxib and weakened by diclofenac or naproxen. Naproxen also improved renal cloudy swelling, necrosis, and reduced glomerular area evoked by PE. The concomitant rises in renal expression of markers of oxidative stress (NOX2/4), extracellular matrix metaloproteinase deposition (MMP9), and prostanoids (PGE2, PGF2α, TXA2) were all more effectively reduced by naproxen compared with celecoxib or diclofenac. Western blotting showed tripled expression of mitogen-activated protein kinases (MAPKs; p-p38, p-JNK1, p-ERK1, p-ERK2) in PE kidneys that was overturned by all NSAIDs, with naproxen producing the largest drop in p-ERK2 expression. The PE-provoked elevation in renal expression of autophagic marker LC3 was reduced by naproxen and diclofenac, but not celecoxib. The data suggests superior effect for naproxen over other NSAIDs in rectifying preeclamptic renal injury and predisposing inflammatory, oxidative, autophagic, and fibrotic signals.

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Utility of glomerular morphometry in diagnosing pediatric renal disease

Cited by 5 publications

References 17 publications

Melatonin mitigates cisplatin-induced acute kidney injury through regulation of the heat shock proteins expressions

Melatonin mitigates cisplatin-induced acute kidney injury through regulation of the heat shock proteins expressions

Do extraglomerular microvasculature and mesenchymal interstitial cell proliferation indicate a stable course of lupus nephritis?

The suppression of MAPK/NOX/MMP signaling prompts renoprotection conferred by prenatal naproxen in weaning preeclamptic rats

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