Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Abu‐Ghanem, Sara; Yafit, Daniel; Ghanayem, Mohamad; Abergel, Avraham; Yehuda, Moshe; Fliss, Dan M.

doi:10.1002/hed.25416

Cited by 7 publications

(9 citation statements)

References 29 publications

(94 reference statements)

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“…PET/CT has also been used as a prognostic tool. A retrospective study described that an absence of pathologic FDG uptake at the first posttreatment PET/CT was associated with better OS 39 …”

Section: Sinonasal Squamous Cell Carcinomamentioning

confidence: 99%

The contemporary management of cancers of the sinonasal tract in adults

Thawani

Kim

Arastu

et al. 2022

CA A Cancer J Clinicians

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Sinonasal malignancies make up <5% of all head and neck neoplasms, with an incidence of 0.5–1.0 per 100,000. The outcome of these rare malignancies has been poor, whereas significant progress has been made in the management of other cancers. The objective of the current review was to describe the incidence, causes, presentation, diagnosis, treatment, and recent developments of malignancies of the sinonasal tract. The diagnoses covered in this review included sinonasal undifferentiated carcinoma, sinonasal adenocarcinoma, sinonasal squamous cell carcinoma, and esthesioneuroblastoma, which are exclusive to the sinonasal tract. In addition, the authors covered malignances that are likely to be encountered in the sinonasal tract—primary mucosal melanoma, NUT (nuclear protein of the testis) carcinoma, and extranodal natural killer cell/T‐cell lymphoma. For the purpose of keeping this review as concise and focused as possible, sarcomas and malignancies that can be classified as salivary gland neoplasms were excluded.

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Section: Sinonasal Squamous Cell Carcinomamentioning

confidence: 99%

The contemporary management of cancers of the sinonasal tract in adults

Thawani

Kim

Arastu

et al. 2022

CA A Cancer J Clinicians

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“…FDG-PET/CT has also been suggested for serving as a prognosticator in patients with sinonasal malignancies [ 58 , 59 ]. Absence of pathologic uptake at the first post-treatment PET/CT is highly predictive of significantly better OS, as for other SCCs of the HN [ 60 ].…”

Section: Pre-treatment Assessmentmentioning

confidence: 99%

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

Ferrari

Taboni

Carobbio

et al. 2021

Cancers

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Sinonasal squamous cell carcinoma is a rare tumor affecting the nasal cavity and paranasal sinuses. Several aspects of this disease, ranging from epidemiology to biology, pathology, diagnosis, staging, treatment, and post-treatment surveillance are controversial, and consensus on how to manage this sinonasal cancer is lacking. A narrative literature review was performed to summarize the current evidence and provide the reader with available data supporting the decision-making process in patients affected by sinonasal squamous cell carcinoma, alongside the authors’ personal opinion on the unsolved issues of this tumor. The review has highlighted several advances in molecular definition of epithelial cancers of the sinonasal tract. Surgery represents the pivot of treatment and is performed through an endoscopic transnasal approach whenever feasible. Open surgery is required for a large proportion of cases. Reconstruction of the defect follows principles of skull base and cranio-maxillo-facial reconstruction. Chemotherapy is given as neoadjuvant treatment or concomitantly to radiotherapy. Photon-based radiation therapy has a crucial role in the adjuvant setting. Particle therapy is providing promising results. Management of the neck should be planned based on the presence of clinically appreciable metastases, primary tumor extension, and need for recipient vessels. Biotherapy and immunotherapy are still underexplored therapeutical modalities.

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“…First, there is a lack of standardized SUV cutoff value suggesting whether a sinonasal lesion is malignant. 36,39 Many studies also showed the inability of PET scans to distinguish postsurgical inflammation from disease recurrence, 50,56 highlighting the…”

Section: Discussionmentioning

confidence: 99%

“…A total of 7 studies were found discussing the role of PET scan for prognosis in sinonasal malignancies. 27,[34][35][36][37][38][39] A summary of each study, their level of evidence, and an assessment of risk of bias can be found in Table 4. All 7 studies were retrospective and had a serious risk of bias.…”

Section: Sinonasal Carcinomasmentioning

confidence: 99%

The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review

El-Adem,

Yang,

Gudis

2023

Am J Rhinol�Allergy

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Background Positron emission tomography (PET) scan is a valuable imaging modality widely used in the management of cancers. Its usage is well defined for most head and neck malignancies. However, there is a lack of consensus regarding the utility of PET scan for sinonasal malignancies. This is highlighted by the latest international consensus statement on endoscopic skull base surgery. Objective This systematic review aims to clarify the role of PET scan in the management of sinonasal malignancies. Methods We conducted a comprehensive literature search using PubMed, MEDLINE, EMBASE, Web of Science, CINAHL, and Cochrane databases for research studies of interest. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) updated statement was used to guide the review. Results In total, 1807 articles were assessed for eligibility. Thirty-nine original papers, published between 2004 and 2021, met inclusion criteria. Seven articles focused on the role of PET scan for inverted papilloma, 23 for sinonasal carcinoma, 4 for melanoma, and 3 for lymphoma, and finally, 3 articles focused on the use of specific PET scan tracers for sinonasal malignancies. Qualitative summaries for each potential role of PET scans were provided. In general, included studies were retrospective in nature with low level of evidence. Conclusions In general, and across all types of sinonasal malignancies, PET scan yielded positive results regarding detection and initial staging. It was also considered as the modality of choice for detection of distant metastases, except in the case of sinonasal lymphoma. PET scan's main limit resides in its inability to detect lesions in or close to the metabolic activity of the brain.

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Utility of first positron emission tomography‐computed tomography scan as a prognostic tool following treatment of sinonasal and skull base malignancies

Cited by 7 publications

References 29 publications

The contemporary management of cancers of the sinonasal tract in adults

The contemporary management of cancers of the sinonasal tract in adults

Sinonasal Squamous Cell Carcinoma, a Narrative Reappraisal of the Current Evidence

The Role of Positron Emission Tomography for the Management of Sinonasal Malignancies: A Systematic Review

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