Utility of Ferritin, Procalcitonin, and C-reactive Protein in Severe Patients with 2019 Novel Coronavirus Disease

Bo, Zhou; She, Jianqing; Wang, Yadan; Ma, Xiancang

doi:10.21203/rs.3.rs-18079/v1

Cited by 64 publications

(53 citation statements)

References 10 publications

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“…In one study with 20 COVID-19 patients, it was found that individuals with severe and very severe COVID-19 exhibited increased serum ferritin level, being serum ferritin in the very severe COVID-19 group significantly higher than in the severe 7 . In agreement with this, another study revealed that in patients who died by COVID-19, ferritin levels were high upon hospital admission and throughout the hospital stay.…”

Section: To the Editormentioning

confidence: 98%

Ferritin levels and COVID-19

Vargas-Vargas

Cortés‐Rojo

2020

Revista Panamericana De Salud Pública

167

152

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Section: To the Editormentioning

confidence: 98%

Ferritin levels and COVID-19

Vargas-Vargas

Cortés‐Rojo

2020

Revista Panamericana De Salud Pública

167

152

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“…The D-dimer which is a marker of coagulation status was also elevated in the diabetic group compared to the nondiabetic group (50.5 vs. 33.3%). The levels of these inflammatory markers have been correlated with the severity of COVID-19 infection [68].…”

Section: Outcome Studies Of Type 2 Diabetic and Nondiabetic Populatiomentioning

confidence: 99%

COVID-19 and Diabetes Mellitus: The Link and Clinical Implications

Ugwueze

Ezeokpo

Nnolim

et al. 2020

Dubai Diabetes Endocrinol J

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Background: Coronavirus disease 2019 (COVID-19) is a pandemic viral infection that has ravaged the world in recent times, and the associated morbidity and mortality have been much more pronounced in those with noncommunicable disease. Diabetes mellitus is one of commonest noncommunicable diseases associated with worsening clinical status in COVID-19 patients. Summary: The aim of this review was to evaluate the receptors and pathogenetic link between diabetes and COVID-19. Both disease conditions involve inflammation with the release of inflammatory markers. The roles of angiotensin-converting enzyme molecule and dipeptidyl peptidase were explored to show their involvement in COVID-19 and diabetes. Pathogenetic mechanisms such as impaired immunity, microangiopathy, and glycemic variability may explain the effect of diabetes on recovery of COVID-19 patients. The effect of glucocorticoids and catecholamines, invasion of the pancreatic islet cells, drugs used in the treatment of COVID-19, and the lockdown policy may impact negatively on glycemic control of diabetic patients. The outcome studies between diabetic and nondiabetic patients with COVID-19 were also reviewed. Some drug trials are still ongoing to determine the suitability or otherwise of some drugs used in diabetic patients with COVID-19, such as dapagliflozin trial and linagliptin trial.

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“…Another meta-analysis performed by Shi et al [34] showed that elevated levels of CK-MB were associated with the severity of COVID-19 in patients. Furthermore, another study found that the serum levels of ferritin were markedly increased in patients with very severe COVID-19 compared with patients with severe COVID-19 [35]. Ferritin is particularly relevant as it is a mediator of immune dysregulation; it has been proposed that under extreme hyperferritinaemia, ferritin exerts direct immune-suppressive and pro-in ammatory effects, contributing to the cytokine storm observed in patients with COVID-19 [36].…”

Section: Resultsmentioning

confidence: 99%

SARS-CoV-2 Identification in Saliva: Are We Interpreting the Results Correctly?

Ramírez-Hinojosa

Rodríguez-Sánchez

Romero-Gonzalez

et al. 2020

Preprint

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BackgroundIn the present study, we obtained cycle threshold (Ct) values by qRT-PCR and compared them with clinical and laboratory data from saliva specimens of inpatients with COVID-19 and asymptomatic health workers (AHW).MethodsSaliva specimens from inpatients with COVID-19 and AHW were studied by qRT-PCR using three sets of primers for the N (N1, N2, and N3) gene of SARS-CoV-2. The Ct values obtained were compared with the clinical and laboratory data.ResultsData from 58 inpatients (37 critically ill patients and 21 patients with severe disease) and 105 AHW were analysed. In our system, the limit of viral detection corresponded to a Ct =46.5; therefore, our analysis focused on comparing the positivity rate obtained when using Ct <40 as the cut-off with that obtained using Ct <46 as the cut-off. The positivity rate was increased when the Ct cut-off of 46 was used as the criterion, yielding a sensitivity of 87.9% for patients and a sensitivity of 43% for AHW. The bivariate analysis revealed an association between Ct <40 for N2 and mechanical ventilation assistance among patients (p=0.013). In addition, the serological values of alanine transaminase (ALT), aspartate-transaminase (AST), lactate dehydrogenase (LDH), ferritin and creatine kinase–MB (CK-MB) showed significant correlations with the Ct values of N1 and N3.ConclusionDue to the intrinsic characteristics of the qRT-PCR process, obtaining amplification curves implies the presence of an active viral replication process, while Ct values may correlate with some clinical data. Our results support the claim that physicians should be informed of the Ct values obtained during the amplification of viral markers, as well as the Ct values that correspond to the limit of detection for viral RNA, which vary according to the characteristics of each system and amplification protocol used.

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Utility of Ferritin, Procalcitonin, and C-reactive Protein in Severe Patients with 2019 Novel Coronavirus Disease

Cited by 64 publications

References 10 publications

Ferritin levels and COVID-19

Ferritin levels and COVID-19

COVID-19 and Diabetes Mellitus: The Link and Clinical Implications

SARS-CoV-2 Identification in Saliva: Are We Interpreting the Results Correctly?

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