Utility of FDG-PET for Investigating Unexplained Plasma CEA Elevation in Patients With Colorectal Cancer

Flanagan, Fidelma; Dehdashti, Farrokh; Ogunbiyi, Olagunju; Kodner, Ira J.; Siegel, Barry A.

doi:10.1097/00000658-199803000-00001

Cited by 233 publications

(98 citation statements)

References 25 publications

(1 reference statement)

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“…The clinical usefulness of 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography (PET) or PET/CT has been well established in patients with CRC for staging and follow-up [6][7][8]. Several studies have demonstrated that the diagnostic performance of PET/CT is superior to that of other imaging techniques [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Value of Surveillance 18F-FDG PET/CT in Colorectal Cancer: Comparison with Conventional Imaging Studies

Choi

Yoo

Park

et al. 2012

Nucl Med Mol Imaging

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Purpose To assess the value of PET/CT for detecting local or distant recurrence in patients who undergo surgery for colorectal cancer (CRC) and to compare the accuracy of PET/CT to that of conventional imaging studies (CIS). Methods Tumor surveillance PET/CT scans done between March 2005 and December 2009 of disease-free patients after surgery with or without adjuvant chemotherapy for CRC were retrospectively studied. CIS (serial enhanced CT from lung base to pelvis and plain chest radiograph) were performed within 1 month of PET/CT. We excluded patients with distant metastasis on initial staging, a known recurrent tumor, and a lack of follow-up imaging. The final diagnosis was based on at least 6 months of follow-up with colonoscopy, biopsy, and serial imaging studies in combination with carcinoembryonic antigen levels. Results A total of 262 PET/CT scans of 245 patients were included. Local and distant recurrences were detected in 27 cases (10.3%). On case-based analysis, the overall sensitivity, specificity, and accuracy were 100, 97.0, and 97.3% for PET/CT and 85.1, 97.0, and 95.8% for CIS, respectively. On lesion-based analysis, PET/CT detected more lesions compared to CIS in local recurrence and lung metastasis. PET/CT and CIS detected the same number of lesions in abdominal lymph nodes, hepatic metastasis, and peritoneal carcinomatosis. PET/CT detected two more metachronous tumors than did CIS in the lung and thyroid gland. Conclusion PET/CT detected more recurrences in patients who underwent surgery for CRC than did CIS and had the additional advantage of evaluating the entire body during a single scan.

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Section: Introductionmentioning

confidence: 99%

Value of Surveillance 18F-FDG PET/CT in Colorectal Cancer: Comparison with Conventional Imaging Studies

Choi

Yoo

Park

et al. 2012

Nucl Med Mol Imaging

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“…FDG-PET is an established imaging tool with a relatively high sensitivity and specificity for detecting recurrence in patients with hematological and solid malignancies, including CRC [23][24][25][26]; however, data on predictive values and survival outcomes of patients undergoing FDG-PET in combination with CT (FDG PET-CT), in the presence of normal or equivocal findings on conventional investigations but raised CEA levels, are lacking. To our knowledge, we present here the largest set of data on diagnostic accuracy of FDG PET-CT in such patients; moreover, survival outcomes of this patient group are also presented for the first time.…”

Section: Discussionmentioning

confidence: 99%

Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging

et al. 2016

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Background. This study had two aims: (a) to evaluate the utility of fluorine 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) in detecting occult disease recurrence with raised carcinoembryonic antigen (CEA)and(b)to establish theprognosticeffects ofearlydetection of disease recurrence in patients with colorectal cancer (CRC). Patients and Methods. Clinico-pathological data were obtained from all consecutive patients undergoing CRC surveillance from 2004 to 2010 who had an elevated CEA level (.3 ng/mL in nonsmokers, .5 ng/mL in smokers) but normal or equivocal conventional investigations. Histopathological confirmation or a minimum of 12 months' clinical and radiological follow-up were required to ascertain disease relapse. Results. A total of 1,200 patients were screened; of those, 88 (59% men; mean age, 66 years [SD, 9.6]) eligible patients (67 with normal and 21 with equivocal results on conventional investigations) were identified. Recurrent disease was detected in 56 of 88 patients (64%).The sensitivity of FDG PET-CT

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“…Studies reported that PET/CT is both sensitive and specific in the diagnosis of malignant bone metastases. In another study bone metastasis was detected in 59 out of 712 patients with PET/CT examination, with a positive predictive value of 98% (37)(38)(39). Distinction of scar tissue from surgery, radiation or recurrence scar is important in patients with previous colon cancer, this is a particular problem for distal colon and rectal cancer where pre-sacral and pelvic scarring changes are common.…”

Section: Pet In Colorectal Cancermentioning

confidence: 98%

“…In 2-4% of patients it is seen as isolated pulmonary metastases and surgery can applied in about half of them. After successful surgery, the 5-year survival rate ranges from 28% to 40% (36)(37)(38)(39). The sensitivity and specificity of positron emission tomography/CT in the detection of malignant solitary pulmonary lymph nodules have been reported as 96% and 83%, respectively.…”

Section: Pet In Colorectal Cancermentioning

confidence: 99%

Restaging colorectal cancer and PET/CT

Çınar

Gençoğlu

Korkmaz

2013

UCD

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Utility of FDG-PET for Investigating Unexplained Plasma CEA Elevation in Patients With Colorectal Cancer

Cited by 233 publications

References 25 publications

Value of Surveillance 18F-FDG PET/CT in Colorectal Cancer: Comparison with Conventional Imaging Studies

Value of Surveillance 18F-FDG PET/CT in Colorectal Cancer: Comparison with Conventional Imaging Studies

Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging

Restaging colorectal cancer and PET/CT

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