Utility of extended pattern prostate biopsies for tumor localization

Schulte, Ryan T.; Wood, David P.; Daignault, Stephanie; Shah, Rajal B.; Wei, John T.

doi:10.1002/cncr.23781

Cited by 38 publications

(28 citation statements)

References 29 publications

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“…Numerous reports have been published comparing findings in transrectal biopsies and RP specimens, and in respect to index tumour detection [12][13][14]. However, data on the prediction of specific tumour location are scarce [15,16].…”

Section: Discussionmentioning

confidence: 97%

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

Lahdensuo

Mirtti

Pétas

et al. 2014

Scandinavian Journal of Urology

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Section: Discussionmentioning

confidence: 97%

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

Lahdensuo

Mirtti

Pétas

et al. 2014

Scandinavian Journal of Urology

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“…Unfortunately, the negative predictive value of uninvolved cores from extended PBx scheme samples was low (24-31%) [83]. Negative extended PBx cores cannot guarantee the absence of cancer in specific regions of the prostate.…”

Section: Number Of Biopsy Cores Versus Grade and Stage Predictionsmentioning

confidence: 99%

“…Negative extended PBx cores cannot guarantee the absence of cancer in specific regions of the prostate. Consequently, a negative extended PBx finding cannot safely justify the use of focal therapies [83].…”

Section: Number Of Biopsy Cores Versus Grade and Stage Predictionsmentioning

confidence: 99%

Effect of the Number of Biopsy Cores on Prostate Cancer Detection and Staging

et al. 2010

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Digital rectal examination, serum concentration of prostate cancer-specific antigen and transrectal ultrasound-guided biopsies are currently the main diagnostic tools to detect evidence of prostate cancer. Different prostatic biopsy strategies have been proposed in order to achieve an optimal prostate cancer detection rate and an accurate characterization of prostate cancer stage and grade. We examined the role of the number of biopsy cores on prostate cancer detection rates at initial and repeat biopsies. Moreover, we examined the relationship between the number of biopsy cores and the detection of insignificant prostate cancer. Finally, we reviewed the ability of biopsy cores in predicting prostate cancer stage and grade at radical prostatectomy. We relied on a PubMed systematic review of the contemporary English language literature using the terms 'prostate cancer', 'diagnosis', 'transrectal ultrasound' and 'prostate biopsy'.

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“…Unfortunately, the negative predictive value of uninvolved cores in the extended PBx scheme has been reported to be low (24%-31%). [61] Consequently, the negative extended Bx findings cannot safely justify the use of focal therapies or define the need for further treatments. [61] As for new tests that may help in solving the dilemma of undetectable PCa, genetic testing, such as that related to prostate cancer antigen 3 (PCA3), may play a significant role in detecting PCa and decrease the number of unnecessary PBxs; however, the availability and technical issues may limit the use of these tests.…”

Section: Number Of Cores Versus Insignificant Pcamentioning

confidence: 99%

“…[61] As for new tests that may help in solving the dilemma of undetectable PCa, genetic testing, such as that related to prostate cancer antigen 3 (PCA3), may play a significant role in detecting PCa and decrease the number of unnecessary PBxs; however, the availability and technical issues may limit the use of these tests. [62] Role of 3 Tesla multiparametric magnetic resonance imaging (3TMPMRI) in the detection of PCa Reducing the number of cores and saving patients from unnecessary PBxs is an ideal target in the detection of PCa.…”

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confidence: 99%

When prostate cancer remains undetectable: The dilemma

Mustafa

Pisters

2015

Turkish Journal of Urology

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Since the first report on the efficacy of sextant biopsy under transrectal ultrasound guidance, there have been many modifications related to the total number of cores and the localization of biopsies to improve the prostate cancer (PCa) detection rate. The 2010 National Comprehensive Cancer Network Early PCa Detection Guidelines noted the 12-core biopsy scheme as the standard. However, this extended biopsy scheme still fails to detect 20% of high-grade PCa that can be detected by detailed pathological evaluation of radical prostatectomy; therefore, there is need for saturation biopsies. The existence of suspicions of PCa after previous negative biopsy or biopsies represents a valid indication for saturation biopsy. There has been no significant increment in morbidity or in insignificant PCa detection rates when a saturation biopsy scheme was used with an extended biopsy scheme. Along with the improvement in the PCa detection rate, accurate oncological mapping of PCa is another important consideration of saturation biopsies. The ideal number of cores and the diagnostic value of saturation biopsy after the failure of initial therapy are some of the issues that need to be addressed. Preliminary reports have shown that magnetic resonance imaging can improve the PCa detection rate, save patients from unnecessary biopsies, and decrease the need for a high number of cores; however, multiple limitations continue to exist.Keywords: Prostate; prostate biopsy; prostate cancer History of prostate biopsy (PBx)Watanabe et al. [1] first introduced the use of transrectal ultrasound-guided (TRUSG) biopsy into the armamentarium of prostate cancer (PCa). Hodge et al. [2] reported on the efficacy of sextant biopsy under TRUS guidance for PCa detection. Initially, only ultrasonically detected hypoechoic areas were sampled. [3,4] In 1995, Stamey et al. [5] suggested that biopsy should be obtained from a more lateral location to better sample the anterior horn of the peripheral zone. Similarly, Norberg et al. [6] noticed that the second set of sextant biopsies performed immediately after the first set increased the PCa detection rate by as much as 30%. These findings prompted investigators to seek alternative biopsy schemes with an increased number of biopsy cores and/or sampling of the lateral peripheral zones for improved PCa detection. [7][8][9][10][11][12][13][14][15] Mc Neal et al. [16] provided the ground for better sampling of peripheral zones with special attention to the anterior horn. These modifications related to the total number of cores and the localization of biopsies improved the PCa detection rate. Extended biopsy schemeUzzo et al. [17] and Karakiewcz et al. [18] were the first to demonstrate an increase in the PCa detection rate in proportion to the number of biopsy cores obtained. Their findings provided the foundation for extended PBx where at least 10 cores are taken. Chen et al. [19] examined various biopsy schemes to define the approach associated with the highest PCa detection rate. They suggested that...

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Utility of extended pattern prostate biopsies for tumor localization

Cited by 38 publications

References 29 publications

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

Effect of the Number of Biopsy Cores on Prostate Cancer Detection and Staging

When prostate cancer remains undetectable: The dilemma

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