Utility of expression of 4-hydroxynonenal tested by immunohistochemistry for cervical cancer
Eva Tsoneva,
Polina Dimitrova,
Metodi Metodiev
et al.
Abstract:Introduction
Cervical cancer (CC) is a leading cause of mortality in women around the world, with the highest incidence rate still being in developing countries. The most common aetiological factor is infection with high-risk human papilloma virus viral strains. Oxidative stress through generation of reactive oxygen species leads to lipid peroxidation and DNA damage. Studies show that reactive lipid electrophiles such as 4-hydroxynonenal (4-HNE) produced in the process play an important role in ca… Show more
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