Utility of eosinophil granule proteins in management of pediatric chronic cough

Abstract

Key Message Pediatric chronic cough often involves eosinophilic inflammation; however, objective measurements are not routinely used in treatment decisions. Accurate biomarkers of eosinophil activity, such as eosinophil-derived neurotoxin (EDN) and cationic proteins (ECP), should be used. EDN, which overcomes the shortcomings of ECP, recently received approval for use in Korean healthcare settings. EDN and ECP can play a role in treatment period and drug selection decisions.