Utility of endobronchial ultrasound‐guided transbronchial needle aspiration in diagnosing non‐specific inflammatory intrathorcacic lymphadenitis

Abstract

Background and objective: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive technique for diagnosing intrathoracic malignancies and some benignancies; however, there are no data available on the utility of EBUS-TBNA for the diagnosis of non-specific inflammatory intrathoracic lymphadenitis.

Clinical Usefulness of Fungal Culture of EBUS-TBNA Needle Rinse Fluid and Core Tissue

“…In addition to mycobacterial culture, EBUS-TBNA core tissue used for fungal culture allows for the diagnosis of granulomatous inflammation related to intrathoracic lymphadenopathy. 7 25 Although histopathologic examination provides more rapid results compared to culture-based methods, it is not sufficient on its own to identify the pathogen. 26 27 The addition of a fungal culture of EBUS-TBNA core tissue to the routine histopathologic examination may facilitate the diagnosis of fungal infections.…”

The role of endobronchial ultrasound-guided transbronchial needle aspiration in isolated intrathoracic lymphadenopathy in non-neoplastic patients: a common dilemma in clinical practice

“…Isolated intrathoracic lymphadenopathy (IL) can be caused by malignant or benign diseases, and it is often difficult to establish a minimally invasive definitive diagnosis. 1 Tuberculosis, sarcoidosis, and other inflammatory diseases are the most common benign conditions and have a substantial clinical and diagnostic overlap; because they demand completely different therapeutic regimens, this creates a dilemma for pathologists and clinicians. 1 - 3 Therefore, histopathological/microbiological confirmation is essential for the differential diagnosis.…”

“…Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has emerged as a useful and minimally invasive diagnostic procedure that provides cytological sampling under real-time ultrasound viewing, resulting in improved accuracy and safety during LN sampling. 1 - 3 , 5 Nowadays, EBUS-TBNA has an established role for IL evaluation, particularly for the diagnosis and staging of cancer patients and for the diagnosis of granulomatous disease, with an accuracy comparable to mediastinoscopy. 4 , 5 However, less is known about the role of EBUS-TBNA in nonspecific IL.…”

The diagnostic value of tissue button technique for specimen accusation during endobronchial ultrasound‐guided transbronchial fine‐needle aspiration

“…Endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) is a minimally invasive modality for nodal staging in lung cancer patients . In addition, EBUS‐TBNA is widely used for the diagnosis of benign conditions, for example, sarcoidosis related mediastinal and hilar lymphadenopathy …”

“…[1][2][3][4][5] In addition, EBUS-TBNA is widely used for the diagnosis of benign conditions, for example, sarcoidosis related mediastinal and hilar lymphadenopathy. 6,7 The observation that certain histologic subtypes of nonsmall cell lung cancer (NSLC) respond differently to particular chemotherapeutic agents and the increasing use of targeted therapies, 8,9 have created a need for precise histologic characterization and molecular analysis for targeted mutations of small biopsy specimens obtained by EBUS-TBNA. [10][11][12] Optimal methodology for specimen handling is an important part of improving the yield of EBUS-TBNA, particularly as molecular analysis becomes increasingly important.…”