Utility of drug provocation tests in the evaluation of quinolone hypersensitivity reactions

Chiriac, Anca Mirela; Tanno, Luciana Kase; Landry, Quentin; Fillard, Anouchka; Grylaki, Maria; Lefevre, S.; Demoly, Pascal

doi:10.1016/j.jaip.2020.10.067

Cited by 2 publications

(4 citation statements)

References 8 publications

(9 reference statements)

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“…These changes may relate to availability, costs and prescription habits. Fluoroquinolones, which cause mast cell degranulation through MRGPRX2, are the most common non‐BL antibiotic involved in DA in Spain, 129 Italy, 32 Vietnam 47 and China 49 and drug‐induced anaphylaxis in the USA 15 due to moxifloxacin 31,129–131 . Ciprofloxacin has been associated with an increased risk for SCARs 131 .…”

Section: Prevalence and Risk Factors Of Da: Specific Drugsmentioning

confidence: 99%

“…30 The most frequent non-beta-lactam (BL) antibiotic involved in DA includes sulfonamides in USA and Australia [19][20][21][22]26 and quinolones in Europe. 20,[31][32][33] Dipyrone is the main cause of anaphylaxis related to nonsteroidal anti-inflammatory drugs (NSAIDs) in South America 34 while it is not available in all European countries or North America where ibuprofen and diclofenac are the most prevalent NSAIDS implicated in DA. 35 Anaphylaxis to neuromuscular blocking agents (NMBAs), although rare, represents one of the leading causes of perioperative anaphylaxis and has also been found to have a geographic distribution, being reported a high frequency in France, Australia, New Zealand, United Kingdom, Norway, Belgium, South Korea, and Spain.…”

Section: Drug Allergy Documentation Prevalence and World Differencesmentioning

confidence: 99%

“…Fluoroquinolones, which cause mast cell degranulation through MRGPRX2, are the most common non-BL antibiotic involved in DA in Spain, 129 Italy, 32 Vietnam 47 and China 49 and drug-induced anaphylaxis in the USA 15 due to moxifloxacin. 31,[129][130][131] Ciprofloxacin has been associated with an increased risk for SCARs. 131 Patients with mastocytosis have an increased risk for fluoroquinolones reactions.…”

Section: Antibioticsmentioning

confidence: 99%

“…Antibiotics represent 14.8% of all anaphylactic reactions reported to FDA (U.S. Food & Drug Administration) from 1999 to 2019 and monoclonal antibodies (mAbs) hypersensitivity reaction (HSR) rate has increased from 2% in 1999 to 17.4% in 2019 30 . The most frequent non‐beta‐lactam (BL) antibiotic involved in DA includes sulfonamides in USA and Australia 19–22,26 and quinolones in Europe 20,31–33 . Dipyrone is the main cause of anaphylaxis related to nonsteroidal anti‐inflammatory drugs (NSAIDs) in South America 34 while it is not available in all European countries or North America where ibuprofen and diclofenac are the most prevalent NSAIDS implicated in DA 35 .…”

Section: Introductionmentioning

confidence: 99%

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Changing patterns in the epidemiology of drug allergy

Doña,

Torres,

Celik

et al. 2023

Allergy

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Drug allergy (DA) remains a complex and unaddressed problem worldwide that often deprives patients of optimal medication choices and places them at risk for life‐threatening reactions. Underdiagnosis and overdiagnosis are common and due to the lack of standardized definitions and biomarkers. The true burden of DA is unknown, and recent efforts in data gathering through electronic medical records are starting to provide emerging patterns around the world. Ten percent of the general population engaged in health care claim to have a DA, and the most common label is penicillin allergy. Up to 20% of emergency room visits for anaphylaxis are due to DA and 15%–20% of hospitalized patients report DA. It is estimated that DA will increase based on the availability and use of new and targeted antibiotics, vaccines, chemotherapies, biologicals, and small molecules, which are aimed at improving patient's options and quality of life. Global and regional variations in the prevalence of diseases such as human immunodeficiency virus and mycobacterial diseases, and the drugs used to treat these infections have an impact on DA. The aim of this review is to provide an update on the global impact of DA by presenting emerging data on drug epidemiology in adult and pediatric populations.

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