Utility of D-dimer in total joint arthroplasty

Cutter, Brenden; Lum, Zachary C.; Giordani, Mauro; Meehan, John P.

doi:10.5312/wjo.v14.i3.90

Cited by 3 publications

(3 citation statements)

References 104 publications

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“…However, it is important to exercise caution when interpreting D-dimer levels in patients with inflammatory and hypercoagulable disorders as diagnostic thresholds may be higher in this patient population [ 56 ].…”

Section: Diagnostic Testsmentioning

confidence: 99%

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Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

et al. 2023

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Periprosthetic joint infection (PJI) is a rare yet devastating complication following total joint arthroplasty (TJA). Early and accurate diagnosis of PJI is paramount in order to maximize the chances of successful treatment. However, we are yet to identify a single “gold standard” test for the diagnosis of PJI. As a result, the diagnosis of PJI is often challenging. Currently, the 2018 ICM definition of PJI is the only validated diagnostic criteria available. This article will review the importance of serum and synovial biomarkers in the diagnosis of PJI. In addition, it will provide a brief overview of the emerging modalities for the identification of infections in this setting.

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Section: Diagnostic Testsmentioning

confidence: 99%

“…Furthermore, they found that D-dimer demonstrated the highest sensitivity for PJI caused by indolent organisms at 94%. However, it is important to exercise caution when interpreting D-dimer levels in patients with inflammatory and hypercoagulable disorders as diagnostic thresholds may be higher in this patient population [56].…”

Section: D-dimermentioning

confidence: 99%

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

et al. 2023

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“…72 The role of D-dimer in the diagnosis of peri-prosthetic infections merits special mention. 73,74 A systematic review and meta-analysis based on 12 studies including a total of 1,818 patients concluded that D-dimer has sufficient diagnostic accuracy to exclude peri-prosthetic joint infection. 75 In addition, the updated 2018 Musculoskeletal Infection Society criteria validated a score for the diagnosis of peri-prosthetic hip and knee infections which included D-dimer levels >860 µg/L.…”

Section: Cancer Inflammation and Infectionmentioning

confidence: 99%

How we manage a high D-dimer

Franchini,

Focosi,

Pezzo

et al. 2023

haematol

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D-dimer, a soluble fibrin degradation product that originates from plasmin-induced degradation of cross-linked fibrin, is an important biomarker of coagulation activation and secondary fibrinolysis that is routinely used to rule out venous thromboembolism (VTE), to evaluate the risk of VTE recurrence as well as the optimal duration of anticoagulant therapy. Besides VTE, D-dimer may be high due to physiologic conditions, including aging, pregnancy and strenuous physical activity. In addition, several disorders have been associated with increased D-dimer levels, spanning from disseminated intravascular coagulation to infectious diseases and cancers. Thus, it is far from unusual for hematologists to have to deal with ambulatory individuals presenting with increased Ddimer without signs or symptoms of thrombus formation. To the management of these cases by the hematologist is dedicated this narrative review.

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An overview of the current diagnostic approach to Periprosthetic Joint Infections

Al-Jabri,

Ridha,

Wood

et al. 2024

Orthopedic Reviews

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The diagnosis of periprosthetic joint infections (PJI) presents a formidable challenge to orthopaedic surgeons due to its complex and diverse manifestations. Accurate diagnosis is of utmost importance, as even mild pain following joint replacement surgery may indicate PJI in the absence of a definitive gold standard diagnostic test. Numerous diagnostic modalities have been suggested in the literature, and international societies have continually updated diagnostic criteria for this debilitating complication. This review article aims to comprehensively examine the latest evidence-based approaches for diagnosing PJI. Through a thorough analysis of current literature, we explore promising diagnostic strategies that have demonstrated effectiveness in identifying PJI. These strategies encompass the utilization of laboratory markers, such as erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), alongside imaging techniques such as magnetic resonance imaging (MRI) and leukocyte scintigraphy. Additionally, we highlight the importance of synovial fluid analysis, including the potential role of alpha-defensin as a biomarker, and examine evolving international diagnostic criteria to standardize and improve diagnostic accuracy.

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Utility of D-dimer in total joint arthroplasty

Cited by 3 publications

References 104 publications

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

Diagnosis of Periprosthetic Joint Infection: The Utility of Biomarkers in 2023

How we manage a high D-dimer

An overview of the current diagnostic approach to Periprosthetic Joint Infections

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