Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies

Rivera-Mancía, Susana; Trujillo, Joyce; Chaverrí, José Pedraza

doi:10.1016/j.jnim.2018.05.001

Cited by 61 publications

(30 citation statements)

References 165 publications

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“…Moreover, curcumin demonstrates hypoglycemic effects in both obese and normal weight rats; in obese rats, the synergistic effects of both of these extracts was much higher than each extract independently. This is also supported by Rivera-Mancía et al [46] and Sohaei et al [47], who showed the hypoglycemic effects of curcumin. As previously described, the use of curcumin in vitro and in animal models of diabetes revealed a variety of potential mechanisms of action to treat diabetes mellitus; however, clinical trials in humans have thus far been inconsistent with these ndings.…”

Section: Discussionsupporting

confidence: 69%

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

Labban

fawaz

Almnaizel

et al. 2021

Preprint

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Background:Obesity is a risk factor for several diseases related to oxidative stress, hyperlipidemia, and hyperglycemia. Several pharmacological agents have been used to treat obesity, but these commonly exhibit undesirable side effects. The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating selected biochemical markers of oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models. Methods:Male albino Wistar rats were divided into eight experimental groups, fed on a normal diet or high-fat diet (HFD), then given mangosteen extract (400 mg /kg body weight/day) and/or curcumin (80 mg/kg body weight/day) for 6 weeks. Oxidative stress markers, glucose, and lipid fractions were measured in the sera. Results:Curcumin was found to be more effective in reducing BMI, while mangosteen extract was found to induce a significant increase in anti-atherogenic marker HDL-C, but was ineffective in reducing dyslipidemia. Mangosteen extract and curcumin effectively reduced blood glucose. Mangosteen did not exhibit any anti-oxidative effects in normal weight rats; however, it induced a significant increase in glutathione in obese rats. Conclusion:The present study demonstrated that mangosteen pericarp extract and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis.

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Section: Discussionsupporting

confidence: 69%

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

Labban

fawaz

Almnaizel

et al. 2021

Preprint

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show abstract

“…In a randomized, placebo-controlled, single blinded, cross-over study, the supplementation with curcumin (tablet containing 180 mg curcumin, one single administration) in healthy individuals, reduced postprandial rise in glucose and insulin serum concentrations [19]. Finally, in a recent review by Rivera-Mancía et al [31], a large amount of evidence from basic research to clinical studies, was found about the antidiabetic properties of curcumin, with emphasis on its antihyperglycemic, anti-inflammatory, and antioxidant activities. The authors also suggested as future perspectives, the need for advances about the interactions of curcumin with conventional antidiabetic drugs, which may give rise to a new complementary therapy in the management of diabetes.…”

Section: Resultsmentioning

confidence: 99%

Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats

Roxo

Arcaro

Gutierres

et al. 2019

Diabetol Metab Syndr

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Background Combination of current antidiabetic agents with natural antioxidants to manage diabetes mellitus and its complications has appeared as an emerging trend. Curcumin, a yellow pigment isolated from Curcuma longa rhizomes, has gained attention due to its beneficial effects in controlling the disturbances observed in diabetes mellitus. The purpose of this study was to investigate if yoghurt enriched with curcumin and metformin, individually or as mixtures, ameliorates physiometabolic parameters, glycoxidative stress biomarkers, and paraoxonase 1 (PON 1) activity in diabetic rats. Methods Streptozotocin-diabetic rats (6-week-old Wistar rats) were treated for 30 days with curcumin and metformin, isolated or as mixtures in yoghurt (10 rats/group). After treatments, the plasma levels of glucose, triacylglycerol, cholesterol, thiobarbituric acid reactive substances (TBARS, a biomarker of lipid oxidation), fluorescent advanced glycation end products (AGEs), and the activity of PON 1, an antioxidant enzyme were assessed. Data were analyzed using one-way analysis of variance (ANOVA) followed by Student–Newman–Keuls test. Results Treatment of diabetic rats with curcumin or metformin alone decreased the plasma levels of glucose, triacylglycerol, cholesterol, TBARS, and fluorescent AGEs, as well as increased the activity of PON 1. The combination of metformin with curcumin further decreased dyslipidemia and TBARS levels in diabetic rats, indicating synergy, and maintained the high levels of PON 1. Conclusion These findings indicated that curcumin combined with metformin may act synergistically on dyslipidemia and oxidative stress, as well as increased PON 1 levels. Therefore, it might be a promising strategy for combating diabetic complications, mainly the cardiovascular events.

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“…TGF-β and IL-8 are involved in the formation of diabetic kidney disease. Thus, curcumin showed potential in lowering complications associated with diabetes ( Rivera-Mancía et al, 2018 ).…”

Section: Role Of Tgf-β Signaling In Diabetesmentioning

confidence: 99%

Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights

et al. 2020

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Despite recent advancements in clinical drugs, diabetes treatment still needs further progress. As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. Specifically, evidence supports that several signaling pathways play pivotal roles in the development of diabetes. However, the exact molecular mechanisms of diabetes still need to be explored. This study examines exciting new hallmarks for the strict involvement of autophagy and TGF-b signaling pathways in the pathogenesis of diabetes and the design of novel therapeutic strategies. Dysregulated autophagy in pancreatic b cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. Consequently, several therapeutic agents such as adiponectin, ezetimibe, GABA tea, geniposide, liraglutide, guava extract, and vitamin D were shown to inhibit diabetes and its complications through modulation of the autophagy pathway. Another pathway, TGF-b signaling pathway, appears to play a part in the progression of diabetes, insulin resistance, and autoimmunity in both type 1 and 2 diabetes and complications in diabetes. Subsequently, drugs that target TGF-b signaling, especially naturally derived ones such as resveratrol, puerarin, curcumin, hesperidin, and silymarin, as well as Propolis, Lycopus lucidus, and Momordica charantia extracts, may become promising alternatives to current drugs in diabetes treatment. This review provides keen insights into novel therapeutic strategies for the medical care of diabetes.

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Utility of curcumin for the treatment of diabetes mellitus: Evidence from preclinical and clinical studies

Cited by 61 publications

References 165 publications

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

Garcinia Mangostana Extract and Curcumin Ameliorate Oxidative Stress, Dyslipidemia, and Hyperglycemia in High Fat Diet-induced Obese Wistar Albino Rats

Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats

Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights

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