Utility of controlled attenuation parameter measurement for assessing liver steatosis in Japanese patients with chronic liver diseases

Abstract

The CAP is a promising tool for rapidly and non-invasively diagnosing steatosis.

Controlled attenuation parameter for the detection and quantification of hepatic steatosis in nonalcoholic fatty liver disease

“…However, such excellent results have not been reproduced in most subsequent studies. Overall, the performance of CAP was good for the diagnosis of hepatic steatosis grade ≥ S1 with AUROC of 0.79–0.89, but it was only fair for steatosis grade ≥ S2 and S3 with AUROC of 0.72–0.79 and 0.70–0.76, respectively …”

“…This is called controlled attenuation parameter (CAP), and it has been suggested to correlate well with hepatic steatosis . Several publications have explored CAP for estimation of hepatic steatosis in patients with chronic liver disease . All of these studies were on patients with chronic liver disease of various etiologies with limited number of NAFLD patients, except one study that consisted of a homogeneous cohort of chronic hepatitis C patients .…”

Diagnostic Accuracy of Controlled Attenuation Parameter Measured by Transient Elastography for the Non-invasive Assessment of Liver Steatosis: a Prospective Study

“…and its potential confounding factors have yet to be determined for an accurate J Gastrointestin Liver Dis, March 2015 Vol. 24 No 1: [35][36][37][38][39][40][41][42] interpretation of its results. In addition, studies taking into consideration the skin-capsule distance would be of great importance, since a distance above 25 mm may lead to overestimation of CAP.…”

“…24 No 1: [35][36][37][38][39][40][41][42] The current "gold standard" for evaluating steatosis is liver biopsy (LB), but it is invasive and may result in severe complications [8]. Furthermore, LB has potential sampling errors and cannot be readily repeated for adequate patient follow-up [9].…”

Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: A meta‐analysis of diagnostic accuracy

“…This method is simple, highly reproducible, and can be completed in an outpatient setting with no significant expertise . Some studies, with small patient populations, have suggested promising results for monitoring steatosis severity . In the present study, we conducted a meta‐analysis to assess the performance of CAP for the detection of hepatic steatosis.…”