Utility of Choline Positron Emission Tomography/Computed Tomography for Lymph Node Involvement Identification in Intermediate- to High-risk Prostate Cancer: A Systematic Literature Review and Meta-analysis

PSMA Ligands for PET Imaging of Prostate Cancer

“…Detection and localization of primary PC are limited by nonspecific uptake in benign intraprostatic pathologies (9). Recent metaanalyses reported a high specificity of 95% but a poor sensitivity of 49% in primary nodal staging (10). Detection rates are positively associated with PSA level but are low (,50%) in patients with early BCR (i.e., PSA , 2 ng/mL) (11).…”

927 Is there still a role for computed tomography and bone scintigraphy in prostate cancer staging? An analysis from the Eureka-1 database

“…However, CT and MRI performances are currently similarly poor compared with histologic diagnosis [20], even if soon iron oxide particles should enhance the detection of enlarged lymph nodes [10,21]. Up to date, choline PET and PET-CT have also provided low sensitivity (49.2 %) in the detection of lymph node metastases prior to surgery in PCa patients [22].…”

A population-based study of the clinical utility of 18F–choline PET/CT for primary metastasis staging of high-risk prostate cancer

“…The specificity of 11 C-and 18 F-choline PET/CT has generally been reported as high, around 90-95%, in primary lymph node staging (Evangelista et al, 2013). The sensitivity is lower, around 50%, but this is still higher than for CT, MRI and BS (Evangelista et al, 2016;Even-Sapir et al, 2006;Pinaquy et al, 2015;Evangelista et al, 2015;Heck et al, 2014).…”