Utility of cardiac troponin measurement after cardiac surgery

Beneficial Effect of the Addition of Nitroglycerin to the Cardioplegic Solution on Lipid Peroxidation During Coronary Artery Bypass Surgery

“…24) All these data confirmed that cardiac troponin release after cardiac surgery is a good reflection of the extent of myocardial damage due to ischemic injury. 8) It has been also suggested that cardiac troponin I (cTnI) specificity to detect myocardial injury may be greater than that of cardiac troponin T. 23) For this reason, in the present study, we measured serum cardiac TnI levels to detect the during ischemia and reperfusion. Hisatomi, et al showed that the addition of nitroglycerin to the cardioplegic solution decreased the concentration of creatine kinase-MB in rat heart.…”

“…Different studies have confirmed that cardiac troponin release after cardiac surgery is a good reflection of the extent of myocardial damage due to ischemic-reperfusion injury. 8) The aim of the present study was two-fold. First, to evaluate the time-course of lipid peroxidation and cardiac markers for myocardial injury in patients undergoing CABG, and second, to compare the possible role of nitroglycerin on LPO and reperfusion injury during CABG.…”

The Comparison and Validity of Troponin I Assay Systems in Diagnosing Myocardial Ischemic Injury After Surgical Coronary Revascularization

“…The role of cTn-I for the diagnosis of PMI 7,8,10,[14][15][16][17] is now well established; however, the fact that the authors and others report different values between commercially available cTn-I assay systems and the fact that the upper reference values differ significantly between various studies 7,15,17 serves to further highlight the need for individual centers to determine reference ranges suitable to their clinical environment; that is, until such time as cTn-I assay systems, surgical techniques (on-pump v off-pump OPCAB), and cardioprotective strategies are standardized.…”

“…This is of concern when a high value for a test is presumably indicative of increasing severity of pathology. If a laboratory changes its assay without warning then there is the possibility for over-or, even worse, underdiagnosis of PMI, especially because the adverse relationship that exists between PMI and patient outcome [1][2][3][4][5][6][7][8][9]17 is increasingly recognized and may warrant early intervention. Accordingly, an overall PMI rate of 35.7% in this series of patients was reported.…”

“…Accurate diagnosis and timely intervention of perioperative myocardial infarction (PMI) are vital because major ischemic injury is associated with reduced hospital [1][2][3][4] and long-term 5,6 survival. Similarly, more recent data suggest that minor ischemic injury after CABG surgery is also associated with adverse short-term 7,8 and medium-term 9 outcome. Accurate assessment of ischemic injury will facilitate the comparison and optimization of myocardial protective strategies with further improved surgical outcome.…”