Utility of bioimpedance methods for the assessment of fat-free mass in adult outpatients with inflammatory bowel disease

Wood, Jessica; Ward, Leigh C.; Sparrow, Miles P.; King, Sontoria D.

doi:10.1016/j.nut.2020.110833

Cited by 7 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…More recently, these investigations have utilized improving imaging and body composition measurement technologies to concentrate specifically on the role of lean tissue and adipose tissue, especially visceral fat, in CD. These have included magnetic resonance imaging (MRI) computed tomography (CT) and, as used in our study, bioimpedance 31 or DEXA 32 . As with our results, most studies determine levels of sarcopenia or relatively low lean tissue indices, combined with elevated adiposity in patients with CD, sometimes correlating with low skeletal mass 33 .…”

Section: Discussionmentioning

confidence: 99%

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Dowling

Jakeman

Norton

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Crohn’s disease (CD) is a debilitating inflammatory bowel condition of unknown aetiology that is growing in prevalence globally. Large-scale studies have determined associations between female obesity or low body mass index (BMI) with risk of CD at all ages or 8– < 40 years, respectively. For males, low BMI entering adult life is associated with increased incidence of CD or ulcerative colitis up to 40 years later. Body composition analysis has shown that combinations of lean tissue loss and high visceral fat predict poor CD outcomes. Here, we assessed dietary intake, physical activity and whole or regional body composition of patients with CD relapse or remission. This anthropometric approach found people with CD, irrespective of relapse or remission, differed from a large representative healthy population sample in exhibiting elevated gynoid fat and reduced android fat. CD is associated with mesenteric adipose tissue, or “creeping fat”, that envelops affected intestine exclusive of other tissue; that fat is localised to the android region of the body. In this context, CD mesenteric adiposity represents a stark juxtaposition of organ-specific and regional adiposity. Although our study population was relatively small, we suggest tentatively that there is a rationale to refer to Crohn’s disease as a fatty intestine condition, akin to fatty liver conditions. We suggest that our data provide early insight into a subject that potentially warrants further investigation across a larger patient cohort.

show abstract

Section: Discussionmentioning

confidence: 99%

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Dowling

Jakeman

Norton

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Previous studies have consistently shown that BIA overestimates muscle mass, using DXA as a reference method to a variable degree. For example, two studies found a bias for estimating SMI between 1.5 and 1.75 kg, 13,14 while another study of 40 patients with IBD overestimated fat‐free mass by a mean of 1.3 kg 15 . In the current study, BIA overestimated fat‐free mass of BIA by threefold more (3.95 kg).…”

Section: Discussionmentioning

confidence: 40%

“…12 BIA has been shown to correlate well with DXA-measured muscle mass in patients with IBD, but agreement with DXA has differed between studies. [13][14][15] Finally, simple anthropometric measurements such as calf and mid-arm circumference have also shown to correlate with muscle mass on DXA in middle-aged and elderly individuals when performed by well-trained professionals. 7,16 Limited studies in IBD have evaluated the utility of anthropometric measurements, especially in relationship to a reference method such as DXA.…”

Section: It Functions By a Low-voltage Current Passing Through The Bodymentioning

confidence: 99%

“…Variables such as height, weight, age and sex are then used in empiric equations to estimate fat mass and fat‐free mass 12 . BIA has been shown to correlate well with DXA‐measured muscle mass in patients with IBD, but agreement with DXA has differed between studies 13–15 . Finally, simple anthropometric measurements such as calf and mid‐arm circumference have also shown to correlate with muscle mass on DXA in middle‐aged and elderly individuals when performed by well‐trained professionals 7,16 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accuracy of ultrasound, bioelectrical impedance analysis and anthropometry as point‐of‐care measurements of skeletal muscle mass in patients with inflammatory bowel disease

Nguyen

Burns

Herath

et al. 2023

Aliment Pharmacol Ther

Self Cite

View full text Add to dashboard Cite

Summary Background Disturbance of skeletal muscle mass has clinically important implications in patients with inflammatory bowel disease (IBD), but accurate quantification requires radiation‐intense techniques. Aims We aimed to compare point‐of‐care muscle assessments and their change with therapy with those using reference‐standard whole‐body dual energy X‐ray absorptiometry (DXA). Methods Adult patients with IBD and healthy controls underwent prospective assessment of muscularity by ultrasound of the dominant arm and both thighs, bioelectrical impedance analysis (BIA), anthropometric measurements, and DXA. Patients with active IBD were assessed again ≥13 weeks after initiating biologic induction therapy. Results In 54 patients with IBD and 30 controls, all muscle assessments correlated significantly with DXA‐derived skeletal muscle index (SMI). In IBD, ultrasound of the arm and legs had the best agreement with DXA‐derived SMI (mean difference 0 kg/m2, 95% limits of agreement −1.3 to 1.3), while BIA overestimated DXA‐derived SMI by 1.07 (−0.16 to +2.30) kg/m2. In 17 patients who underwent biologic therapy, the percentage change in DXA‐derived SMI correlated significantly with the percentage change in all other muscle assessment techniques. Responders (n = 9) increased SMI from baseline to follow‐up when derived from DXA (mean 7.8–8.5 kg/m2, p = 0.004), ultrasound of the arm and legs (300–343 cm2, p = 0.021) and BIA (9.2–9.6 kg/m2, p = 0.011). Conclusions Ultrasound of the arm and legs out‐performed other point‐of‐care methods in its accuracy of measuring muscle mass. All methods, except mid‐arm circumference, were responsive to therapy‐induced change. Ultrasound is the preferred non‐invasive test for measuring muscle mass in patients with IBD.

show abstract

“…This is significant because FFM depletion has been associated with negative outcomes, including major postoperative complications predicting a small bowel resection, primary non-response to antitumor necrosis factor (TNF) agents, and osteopenia. Traditional nutritional measurements, like BMI, correlate poorly with indices of FFM in patients with CD, resulting in a risk for under recognition and underestimation of the extent of nutrition depletion when relying only on weightbased indicators of nutritional status (Wood, 2020). Reduced muscle mass has been included in the Global Consensus for Diagnosing Malnutrition in Adult Patients (Cedeholm et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Body Muscle Mass Metabolic Data Analysis in Association with Crohn’s Disease Activity

Zaļizko

Urbāne

Roshofa

et al. 2022

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

View full text Add to dashboard Cite

Malnutrition is a common complication of Crohn’s disease (CD) patients and it is correlated with alterations of the body composition and disease activity. Our prospective pilot study included hospitalised CD patients, age ≥ 18 years. Patients were assessed using the Nutritional Risk Score (NRS2002), the Malnutrition Universal Screening Tool (MUST), and body bioelectrical impedance analysis. Twenty-three hospitalised patients (median age 36.5, interquartile range (IQR): 28.5–51.5 years) were enrolled; the median CD activity index was 128 (IQR = 6.0–207.0). The study group comprised 48% (n = 11) patients with low CD activity and 52% (n = 12) with high disease activity. According to NRS2002 and MUST, 70% (n = 16) CD patients had malnutrition risk and were in need of nutritional support. The median BMI was lower for the CD group (21.10 [IQR = 19.2–23.3]) than for the control group (23.4 [IQR = 21.5–25.8]) (p = 0.014). In terms of deviation from standard weight, 39% (n = 9) of CD patients showed reduced % body fat. Reduced muscle mass was observed in 48% (n = 11) of CD patients. CD patients with high disease activity had a noticeably increased risk of malnutrition. Identification of the reduction in soft lean muscle mass in CD patients can be used as an anticipatory indicator of disease activity.

show abstract

Utility of bioimpedance methods for the assessment of fat-free mass in adult outpatients with inflammatory bowel disease

Cited by 7 publications

References 32 publications

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Adults with Crohn’s disease exhibit elevated gynoid fat and reduced android fat irrespective of disease relapse or remission

Accuracy of ultrasound, bioelectrical impedance analysis and anthropometry as point‐of‐care measurements of skeletal muscle mass in patients with inflammatory bowel disease

Body Muscle Mass Metabolic Data Analysis in Association with Crohn’s Disease Activity

Contact Info

Product

Resources

About