Utility of a Single Itch-Related Question and the Skindex-10 Questionnaire for Assessing Pruritus and Predicting Health-Related Quality of Life in Patients Receiving Hemodialysis

Lopes, Marcelo Barreto; Karaboyas, Angelo; Sukul, Nidhi; Tsuruya, Kazuhiko; Salmi, Issa Al; Asgari, Elham; Alyousef, Anas; Schaufler, Thilo; Walpen, Sebastian; Menzaghi, Frédérique; Pisoni, Ronald L.

doi:10.1016/j.xkme.2022.100476

Cited by 10 publications

(3 citation statements)

References 28 publications

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“…These results are consistent with the results of Kumar et al [ 49 , 50 ]. A previous study [ 17 ] showed that dry skin and itching correlated with decreased quality of life and depression. At the same time, dry skin and itching will cause or worsen other symptoms (particularly sleep disorder symptoms) and are independent predictors of mortality rate.…”

Section: Discussionmentioning

confidence: 99%

“…Especially in older patients, with increasing age, the symptoms occur more often and are more severe, thereby negatively affecting the patients’ quality of life. For example, fatigue may lead to the occurrence of cardiovascular disease and even death of patients [ 16 ], while skin itching can lead to the decline of sleep quality of patients and bring negative emotions to patients [ 17 , 18 ], so there is an urgent need for comprehensive and efficient symptom management programs to alleviate the occurrence of symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Exploration of symptom clusters during hemodialysis and symptom network analysis of older maintenance hemodialysis patients: a cross-sectional study

Zhou¹,

Gu²,

Cheng³

et al. 2023

BMC Nephrol

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Background Symptom networks can provide empirical evidence for the development of personalized and precise symptom management strategies. However, few studies have established networks of symptoms experienced by older patients on maintenance hemodialysis. Our goal was to examine the type of symptom clusters of older maintenance hemodialysis patients during dialysis and construct a symptom network to understand the symptom characteristics of this population. Methods The modified Dialysis Symptom Index was used for a cross-sectional survey. Network analysis was used to analyze the symptom network and node characteristics, and factor analysis was used to examine symptom clusters. Results A total of 167 participants were included in this study. The participants included 111 men and 56 women with a mean age of 70.05 ± 7.40. The symptom burdens with the highest scores were dry skin, dry mouth, itching, and trouble staying asleep. Five symptom clusters were obtained from exploratory factor analysis, of which the clusters with the most severe symptom burdens were the gastrointestinal discomfort symptom cluster, sleep disorder symptom cluster, skin discomfort symptom cluster, and mood symptom cluster. Based on centrality markers, it could be seen that feeling nervous and trouble staying asleep had the highest strength, and feeling nervous and feeling irritable had the highest closeness and betweenness. Conclusions Hemodialysis patients have a severe symptom burden and multiple symptom clusters. Dry skin, itching, and dry mouth are sentinel symptoms in the network model; feeling nervous and trouble staying asleep are core symptoms of patients; feeling nervous and feeling irritable are bridge symptoms in this symptom network model. Clinical staff can formulate precise and efficient symptom management protocols for patients by using the synergistic effects of symptoms in the symptom clusters based on sentinel symptoms, core symptoms, and bridge symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploration of symptom clusters during hemodialysis and symptom network analysis of older maintenance hemodialysis patients: a cross-sectional study

Zhou¹,

Gu²,

Cheng³

et al. 2023

BMC Nephrol

View full text Add to dashboard Cite

show abstract

“…Data on 2 additional patient-reported pruritus measures, a verbal rating scale and the SKINDEX-10, were collected ( 12 , 19 ). These 2 measures are not included in the mapping study as they have been shown to not add additional information, but we exploit their informational content for data checking and cleaning ( 20 ). The EQ-5D-5L is a 5-item standardized instrument developed as a measure of generic health-related quality of life at the time of completion and it consists of a descriptive system that comprises 5 dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, for which respondents select 1 of 5 levels, from no problems to unbearable or being unable to perform the domain ( 13 ).…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Standardized Measures of Chronic Kidney Disease-associated Pruritus Intensity and Health-related Quality of Life Measured with the EQ-5D Questionnaire: A Mapping Study

Hernandez Alava,

Sasso,

Hnynn Si

et al. 2023

Acta Derm Venereol

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Chronic kidney disease-associated pruritus is linked with decreased health-related quality of life assessed using disease-specific instruments. The extent to which worsening pruritus reduces generic quality of life assessed using the EQ-5D instrument is unknown. Prevalent kidney failure patients receiving in-centre haemodialysis from 5 centres completed the EQ-5D-5L quality of life measure, worst Itching Intensity Numerical Rating Scale and 5-D itch pruritus instruments. Latent class models were used to identify clusters of patients with similarly affected body parts, and mixture models were used to map the pruritus measures to the EQ-5D. Data on 487 respondents were obtained. Latent class analysis identified 3 groups of patients who had progressively worsening severity and an increasing number of body parts affected. Although the worst itching intensity numerical rating scale and 5-D itch instruments correlated with each other, only the latter had a strong relationship with EQ-5D. When controlling for age, sex, diabetes and years receiving dialysis, the meanpredicted EQ-5D utility (1: perfect health, 0: dead) decreased progressively from 0.69 to 0.41. These findings suggest that pruritus instruments that include domains capturing how the individual is physically, mentally and socially affected by their pruritus, in addition to severity, more closely approximate the EQ-5D generic quality of life measure.

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Impacto del prurito asociado a la enfermedad renal crónica (Pa-ERC) en la calidad de vida de los pacientes en hemodiálisis en España

et al. 2023

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Utility of a Single Itch-Related Question and the Skindex-10 Questionnaire for Assessing Pruritus and Predicting Health-Related Quality of Life in Patients Receiving Hemodialysis

Cited by 10 publications

References 28 publications

Exploration of symptom clusters during hemodialysis and symptom network analysis of older maintenance hemodialysis patients: a cross-sectional study

Exploration of symptom clusters during hemodialysis and symptom network analysis of older maintenance hemodialysis patients: a cross-sectional study

Relationship Between Standardized Measures of Chronic Kidney Disease-associated Pruritus Intensity and Health-related Quality of Life Measured with the EQ-5D Questionnaire: A Mapping Study

Impacto del prurito asociado a la enfermedad renal crónica (Pa-ERC) en la calidad de vida de los pacientes en hemodiálisis en España

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