Utility of a Liquid-Based, Monolayer Preparation in the Evaluation of Thyroid Lesions by Fine Needle Aspiration Biopsy

Saleh, Husain; Bassily, Nader; Hammoud, Marouane

doi:10.1159/000325113

Cited by 34 publications

(49 citation statements)

References 14 publications

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“…Studies have evaluated the utility of TP in thyroid FNA, but the results have been conflicting. Some investigators reported TP to be inferior to CP, whereas others reported TP to be equivalent and even superior to CP [1,2,3,4]. We retrospectively reviewed our patients treated with thyroid FNA using the TP preparation.…”

Section: Discussionmentioning

confidence: 99%

“…First, since the 1991 US Federal Drug Administration approval of ThinPrep (TP) for processing nongynecological material, a growing number of laboratories are processing thyroid FNA needle rinses with this method [1,2,3,4]. The application of TP in combination with conventional smears has been shown to reduce the nondiagnostic rate [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…The application of TP in combination with conventional smears has been shown to reduce the nondiagnostic rate [1,2]. However, the efficacy of TP alone in triaging thyroid nodules is still controversial [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Factors Influencing the Reliability of Thyroid Fine-Needle Aspiration: Analysis of Thyroid Nodule Size, Guidance Mode for Aspiration and Preparation Method

H¹,

Zhang²,

Zhao³

et al. 2015

Acta Cytologica

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Objective: We aimed to clarify the influence of ThinPrep preparation, nodule size and guidance mode on the accuracy of thyroid fine-needle aspiration (FNA). Methods: A total of 1,240 thyroid FNAs were reviewed and 489 cases with histological correlations were enrolled in this study. Results: Of the 489 total cases examined, 101 were processed with both ThinPrep and conventional preparation and 388 entirely with ThinPrep. The overall nondiagnostic rate, sensitivity and accuracy of FNA were 2.0, 91.0 and 89.4%, respectively. The cases with a preoperative ultrasound (n = 469) were grouped according to nodule size. The nondiagnostic rate, sensitivity and accuracy of FNA did not differ significantly with nodule size (p1 = 0.339, p2 = 0.179, p3 = 0.119). A total of 101 resections were performed with palpation-guided FNA and 388 were performed with ultrasound-guided FNA. The nondiagnostic rates, sensitivity and accuracy of FNA were similar in these two groups. Conclusions: The ThinPrep technique is a valid method for thyroid FNA and is effective for thyroid nodules ≥0.5 cm. The reliability of FNA results is not reduced with larger nodules. The use of palpation-guided FNA for palpable solid nodules is also effective.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Influencing the Reliability of Thyroid Fine-Needle Aspiration: Analysis of Thyroid Nodule Size, Guidance Mode for Aspiration and Preparation Method

H¹,

Zhang²,

Zhao³

et al. 2015

Acta Cytologica

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show abstract

“…Modified or alternative techniques, such as using a different type and size of biopsy needle or additional liquid-based cytology, are related to better adequacy rates [19,20,21,22]. In addition, both experience-based operator dependency and interobserver variance between cytotechnologists and cytopathologists have repeatedly been demonstrated [23,24,25,26].…”

Section: Introductionmentioning

confidence: 99%

Thyroid Ultrasound-Guided Fine-Needle Aspiration: The Positive Influence of On-Site Adequacy Assessment and Number of Needle Passes on Diagnostic Cytology Rate

et al. 2016

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Objective: Nondiagnostic cytology is the most important limitation of thyroid ultrasound-guided fine-needle aspiration (US-FNA). This study aimed to identify factors associated with the adequacy rate of thyroid US-FNA. Study Design: Consecutive thyroid US-FNAs (2006-2013) were retrospectively included. Attending radiologists, radiology fellows and radiology residents performed US-FNA, usually involving 2-3 needle passes. In more recent years, rapid on-site adequacy assessment (ROSAA) was performed to ensure specimen adequacy. US characteristics, procedural variations and cytology results were extracted from US and pathology reports and statistically evaluated. Results: Diagnostic cytology was obtained in 64.6% of 1,381 thyroid US-FNAs. Factors associated with nondiagnostic cytology were ROSAA (74.6% diagnostic cytology, OR 0.55, 95% CI 0.42-0.71), ≥3 clinic visits for US-FNA of the same thyroid nodule (54.7%, OR 1.56, 95% CI 1.16-2.10) and increased intranodular vascularization (51.8%, OR 1.73, 95% CI 1.17-2.57). With ROSAA, an increasing number of needle passes demonstrated improving adequacy rates. The adequacy rate was not operator-dependent. Conclusion: This study demonstrates that ROSAA improves the adequacy rate of thyroid US-FNA. Without ROSAA, we recommend performing at least 3 needle passes. Less diagnostic cytology is obtained from nodules with increased intranodular vascularization or from those undergoing US-FNA ≥3 times.

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“…Amrikachi et al 13 found that only 3% of cases diagnosed as follicular neoplasms on FNA smears proved to be benign adenomatous nodules. Saleh et al 14 found that the rate of histologically confirmed benign colloid nodules was similar for LBP and conventional smears.…”

Section: Commentmentioning

confidence: 95%

Performance Differences Between Conventional Smears and Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Samples: Analysis of 47 076 Responses in the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytology

Fischer

Clayton²,

Bentz³

et al. 2013

Archives of Pathology & Laboratory Medicine

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Utility of a Liquid-Based, Monolayer Preparation in the Evaluation of Thyroid Lesions by Fine Needle Aspiration Biopsy

Cited by 34 publications

References 14 publications

Factors Influencing the Reliability of Thyroid Fine-Needle Aspiration: Analysis of Thyroid Nodule Size, Guidance Mode for Aspiration and Preparation Method

Factors Influencing the Reliability of Thyroid Fine-Needle Aspiration: Analysis of Thyroid Nodule Size, Guidance Mode for Aspiration and Preparation Method

Thyroid Ultrasound-Guided Fine-Needle Aspiration: The Positive Influence of On-Site Adequacy Assessment and Number of Needle Passes on Diagnostic Cytology Rate

Performance Differences Between Conventional Smears and Liquid-Based Preparations of Thyroid Fine-Needle Aspiration Samples: Analysis of 47 076 Responses in the College of American Pathologists Interlaboratory Comparison Program in Non-Gynecologic Cytology

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