Utility of 4‐Chloro‐7‐Nitrobenzofurazan for the Spectrofluorimetric Determination of Butylated Hydroxyanisole and Propyl Gallate in Foodstuffs

Chen, Miao; Tai, Zhigang; Hu, Xingfang; Liu, Mousheng; Yang, Yaling

doi:10.1111/j.1750-3841.2011.02607.x

Cited by 3 publications

(2 citation statements)

References 23 publications

(17 reference statements)

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“…BHT and BHA were also determined simultaneously by spectrophotometry in pharmaceutical preparations and chewing gums 44 . Spectrofluorimetric determination of Butylated hydroxyanisole and propyl gallate in foodstuffs was reported by derivatization with 4-chloro-7-nitrobenzofurazan (NBD-Cl) 45 . BHA was detected in foodstuffs by measuring the emission intensity at 323 nm upon excitation with a wavelength of 293 nm 46 .…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of butylated hydroxytoluene and butylated hydroxyanisole in their combined formulation: application to butylated hydroxyanisole residual analysis in milk and butter

Galal,

Elzanfaly,

Hussien

et al. 2024

Sci Rep

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Butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA) are two antioxidants that have been extensively used in many applications. Both are well known for their debatable health risks due to their multiple intake sources. Therefore, conservative limits are set for them in different regulations adapted to the matrices in which they exist. Here we present a simple spectrofluorimetric method for the determination of BHT and BHA based on their native fluorescence and synchronous scanning mode. The type of solvent and the interval between emission and excitation wavelengths were carefully optimized. Under the optimized conditions, good linearities were obtained between the emission intensity and the corresponding concentrations of BHT and BHA over the range of 3–18 µg/mL and 0.1–7 µg/mL, respectively with a good correlation coefficient (r > 0.99). The limits of detection were 0.9 and 0.02 µg/mL, and the quantification limits were 3 and 0.05 µg/mL for BHT and BHA, respectively. The suggested procedure was validated according to ICH guidelines Q2 (R1). Furthermore, the method’s greenness was assessed by three different methods, and it proved to be eco-reasonable. The method was successfully applied to the determination of BHT and BHA in pharmaceutical formulations. We also applied the suggested method for monitoring the residual BHA in conventional, powdered milk and butter, with good recovery in spiked samples.

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Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of butylated hydroxytoluene and butylated hydroxyanisole in their combined formulation: application to butylated hydroxyanisole residual analysis in milk and butter

Galal,

Elzanfaly,

Hussien

et al. 2024

Sci Rep

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“…The currently employed methods for TBHQ or BHA detection primarily include high-performance liquid chromatography, 10 gas chromatography, 11,12 capillary electrophoresis, 13 fluorescence detection, 14,15 and electrochemistry. [16][17][18][19] In particular, electroanalytical methods are widely adopted in trace and ultra-trace analyses owing to their rapidity, sensitivity, and accuracy.…”

Section: Introductionmentioning

confidence: 99%

Zirconium‐based metal–organic framework and functionalized carbon black composite for simultaneous electrochemical detection of tert‐butylhydroquinone and butylhydroxyanisole

Feng,

Wang,

Liu

et al. 2024

Applied Organom Chemis

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In this paper, a porous zirconium‐based metal–organic framework (NH2‐UiO‐66) and functionalized carbon black (FCB) composite was prepared through a one‐pot hydrothermal method, and a novel electrochemical sensor based on NH2‐UiO‐66@FCB modified glassy carbon electrode (NH2‐UIO‐66@FCB/GCE) was developed for the simultaneous sensoring of butylhydroxyanisole (BHA) and tert‐butylhydroquinone (TBHQ). The morphology and structure of NH2‐UiO‐66@FCB were characterized through scanning electron microscopy, X‐ray diffraction, Fourier transform infrared spectroscopy, and X‐ray photoelectron spectrum. The electrochemical behaviors of the NH2‐UiO‐66@FCB/GCE were investigated using cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. Under optimized experimental conditions, the linear ranges for TBHQ and BHA detection were determined to be 0.12–460 μM and 0.7–420 μM, respectively, with their corresponding detection limits of 0.072 μM and 0.29 μM. Furthermore, the sensor exhibited excellent selectivity, repeatability and stability, and successfully used for the simultaneous detection of TBHQ and BHA in food samples.

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Synthetic phenolics as antioxidants for food preservation

Makahleh

Saad

Bari

2015

Handbook of Antioxidants for Food Preservation

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Utility of 4‐Chloro‐7‐Nitrobenzofurazan for the Spectrofluorimetric Determination of Butylated Hydroxyanisole and Propyl Gallate in Foodstuffs

Abstract: In this spectrofluorimetric method, NBD-Cl as a derivation agent is used to detect synthetic phenolic antioxidants. The method specificity has been greatly improved; there was no interference from other commonly used phenolic substances.

Cited by 3 publications

References 23 publications

Spectrofluorimetric determination of butylated hydroxytoluene and butylated hydroxyanisole in their combined formulation: application to butylated hydroxyanisole residual analysis in milk and butter

Spectrofluorimetric determination of butylated hydroxytoluene and butylated hydroxyanisole in their combined formulation: application to butylated hydroxyanisole residual analysis in milk and butter

Zirconium‐based metal–organic framework and functionalized carbon black composite for simultaneous electrochemical detection of tert‐butylhydroquinone and butylhydroxyanisole

Synthetic phenolics as antioxidants for food preservation

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