Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: antibacterial activity

Hamid, Atef M. Abdel; Shehta, W.

doi:10.1007/s13738-018-1464-2

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…Atef M. Abdel Hamid and reported synthesis of 5‐(Furan‐2‐yl)‐7‐methyl‐[1,2,4]triazolo[4,3‐f]pyrimidine‐8‐carbonitrile 211 from 2‐(furan‐2‐yl)‐4‐hydrazinyl‐6‐methylpyrimidine‐5‐carbonitrile 210 (Scheme 40). [100] …”

Section: Synthesis Using Hydrazines and Hydrazonesmentioning

confidence: 99%

“…[99] Atef M. Abdel Hamid and reported synthesis of 5-(Furan-2yl)-7-methyl- [1,2,4]triazolo [4,3-f]pyrimidine-8-carbonitrile 211 from 2-(furan-2-yl)-4-hydrazinyl-6-methylpyrimidine-5-carbonitrile 210 (Scheme 40). [100] Dashyan and Paronikyan has demonstrated the construction of cyclopenta [4',5'] [102] Ethyl-methyl-1-(4-nitrophenyl)-5-phenyl-3-(thiophen-2-yl)-1,5-dihydro- [1,2,4]triazolo [4,3-a]pyrimidine-6-carboxylate…”

Section: Synthesis Using Hydrazines and Hydrazonesmentioning

confidence: 99%

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Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

Kaushik,

Kumar,

Khokhar

et al. 2023

ChemistrySelect

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Abstract1,2,4‐Triazolopyrimidines scaffold spaciously acknowledged with anticancer, antimalarial, antitubercular and many other fascinating biological applications in recent years (2015–2022). Moreover, numerous mild synthetic methodologies reported, which has been summarized as (i) condensation of 2‐amino‐1,2,4‐triazole or 5‐amino‐1,2,4‐triazole with 1,3‐dielectrophilic equivalents like 1,3‐diketones, β‐ketoester (ii) oxidative‐cyclization of hydrazones or related analogues. This review would flourish the synthetic and medicinal chemist to design more bioactive 1,2,4‐triazolopyrimidines molecules for drug development with enhanced binding interactions, structural features with the help discussed SAR and cost effective methodologies in the coming years.

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Section: Synthesis Using Hydrazines and Hydrazonesmentioning

confidence: 99%

Section: Synthesis Using Hydrazines and Hydrazonesmentioning

confidence: 99%

Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

Kaushik,

Kumar,

Khokhar

et al. 2023

ChemistrySelect

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“…[23][24][25] Moreover, some fluorescent compounds are utilized in studying the environmental pollution. [26,27] Thus, in the light of these reports and in continuation of our studies on the synthesis and properties of furantagged condensed pyrimidines, [28][29][30] we report herein a synthetic approach for a highly fluorescent series of these compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and fluorescent properties of some Furan‐tagged Thieno[2,3‐d]pyrimidines and Thieno[2,3‐d:4,5‐d']dipyrimidines

Hamid

Hamed

2020

Journal of Heterocyclic Chem

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Intermolecular cyclization of pyrimidinethiol 1 with ethyl chloroacetate and chloroacetonitrile furnished thieno[2,3-d]pyrimidines 2a,b. Hydrazinolysis of o-aminoester 2a gave acid hydrazide 3, which was cyclized with various electrophilic reagents including formic acid, triethyl orthoformate, acetic anhydride, p-chlorobenzaldehyde then triethyl orthoformate, carbon disulfide, and acetylacetone affording thienopyrimidine derivatives 4 to 10. Another thienopyrimidine series could be obtained via treatment of o-aminocarbonitrile 2b with a variety of reagents giving derivatives 11 to 17. The fluorescent measurements for a group of the synthesized compounds at room temperature demonstrated high fluorescent properties.

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Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

Hamid

2019

J IRAN CHEM SOC

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Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile as a precursor for the synthesis of some novel pyrimidines: antibacterial activity

Cited by 6 publications

References 21 publications

Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

Synthesis and fluorescent properties of some Furan‐tagged Thieno[2,3‐d]pyrimidines and Thieno[2,3‐d:4,5‐d']dipyrimidines

Addition–cyclization reactions of furan-2-carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

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