Utility and risk of dermatologic medications during the<scp>COVID</scp>‐19 pandemic

Goldust, Mohamad; Hartmann, Karin; Abdelmaksoud, Ayman; Navarini, Alexander A.

doi:10.1111/dth.13833

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…The effect of cyclosporine therapy on coronavirus infection course has been widely studied ( Figure 2 ). The topic became extremely prescient with the circumstances of the COVID-19 epidemic [ 44 , 45 , 46 , 47 , 48 ].…”

Section: Cyclosporine and Viral Infectionsmentioning

confidence: 99%

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

Głowacka

Rudnicka

Warszawik-Hendzel

et al. 2020

Biology

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This review updates current knowledge regarding the risk of viral infections, including COVID-19, in patients treated with cyclosporine. We also shortly refer to bacterial infections and parasitic infestations in patients treated with cyclosporin. Cyclosporine is an immunosuppressive drug, which is widely used in medicine, including in the treatment of autoimmune skin diseases in dermatology, rheumatology, ophthalmology and nephrology, and in organ transplantation. A usual concern associated with immunosuppressive treatment is the potential risk of infections. Interestingly, several data indicate a relatively low risk of infections, especially viral infections, in patients receiving cyclosporine. It was shown that cyclosporine exerts an inhibitory effect on the replication of some viruses, or may have a potentially beneficial effect on the disease course in infections. These include hepatitis C, influenza virus, rotavirus, human immunodeficiency virus and coronavirus infections. Available data indicate that cyclosporine may have a beneficial effect on COVID-19, which is caused by the coronavirus SARS-COV2.

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Section: Cyclosporine and Viral Infectionsmentioning

confidence: 99%

The Antiviral Properties of Cyclosporine. Focus on Coronavirus, Hepatitis C Virus, Influenza Virus, and Human Immunodeficiency Virus Infections

Głowacka

Rudnicka

Warszawik-Hendzel

et al. 2020

Biology

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“…Regarding those changes observed in patients with COVID-19, some authors have recently proposed the therapeutic benefit of dapsone [ 7 , 8 ] as a treatment in patients with lung damage generated by the SARS-CoV-2 virus, since it could modulate the production of pro-inflammatory cytokines [ 160 ], the secretion of IL-8 from bronchial epithelial cells, by regulating TNFα from activated mononuclear cells and the decrease in MPO activity [ 161 ]. Finally, Schön, et al , (2020) [ 10 ], in a recent review, discussed the therapeutic benefit of various immunological therapies that regulate the main inflammatory mechanisms in COVID-19, from a basic aspect and its clinical translational implications.…”

Section: Discussionmentioning

confidence: 99%

Dapsone, More than an Effective Neuro and Cytoprotective Drug

Dı́az-Ruiz

Nader-Kawachi

Calderón-Estrella

et al. 2022

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Background: Dapsone (4,4'-diamino-diphenyl sulfone) is a synthetic derivative of sulfones, with the antimicrobial activity described since 1937. It is also a drug traditionally used in dermatological therapies due to its anti-inflammatory effect. In recent years its antioxidant, antiexcitotoxic, and antiapoptotic effects have been described in different ischemic damage models, traumatic damage, and models of neurodegenerative diseases, such as Parkinson's (PD) and Alzheimer's diseases (AD). Finally, dapsone has proven to be a safe and effective drug as a protector against heart, renal and pulmonary cells damage; that is why it is now employed in clinical trials with patients as a neuroprotective therapy by regulating the main mechanisms of damage that lead to cell death. Objective: To provide a descriptive review of the evidence demonstrating the safety and therapeutic benefit of dapsone treatment, evaluated in animal studies and various human clinical trials. Methods: We conducted a review of PubMed databases looking for scientific research in animals and humans, oriented to demonstrate the effect of dapsone on regulating and reducing the main mechanisms of damage that lead to cell death. Conclusion: The evidence presented in this review shows that dapsone is a safe and effective neuro and cytoprotective treatment that should be considered for translational therapy.

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“…the novel coronavirus (COVID-19) has spread worldwide and affected almost all parts of the globe with unprecedented epidemiological, psychosocial, political, financial, and educational repercussions. [1][2][3] In dire times like this, other specialists including dermatologists have stepped up and volunteered their services to help ease the burden and share the medical workload. Dermatologists across the globe have been screening outpatients, manning isolation wards, tending to non-dermatology wards, assisting in stepdown intensive care units, and so on.…”

mentioning

confidence: 99%