Utility and morphologic features of granulomas on rapid on-site evaluation of endobronchial ultrasonography-guided fine-needle aspiration

Odronic, Shelley I.; Maskovyak, Amanda; Springer, Bridgette; Dyhdalo, Kathryn S.; Abdul‐Karim, Fadi W.; Booth, Christine N.

doi:10.1016/j.jasc.2013.09.003

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…ROSE can guide the bronchoscopy process in real time, initially determine the adequacy and qualification rate of specimens and guide further auxiliary examinations, including microbial culture and antigen detection, which helps increase the positive diagnostic rate of infectious diseases. 23 , 24 In this study, EBUS‐TBLB combined with ROSE significantly improved the diagnostic positivity rate and on this basis, when combined with CrAg, achieved the same diagnostic results as CT‐PNB. ROSE can evaluate the quality of the sample during bronchoscopy, distinguish the cytological manifestations of cryptococcal infection and the structural characteristics of the pathogen in the specimen in time and help guide the doctor to send the lavage fluid or blood sample for CrAg testing to improve the diagnosis rate of cryptococcal disease.…”

Section: Discussionsupporting

confidence: 56%

“…Compared with CT‐PNB, EBUS‐TBLB acquires a smaller tissue size, is less traumatic and can be performed multiple times. ROSE can guide the bronchoscopy process in real time, initially determine the adequacy and qualification rate of specimens and guide further auxiliary examinations, including microbial culture and antigen detection, which helps increase the positive diagnostic rate of infectious diseases 23,24 . In this study, EBUS‐TBLB combined with ROSE significantly improved the diagnostic positivity rate and on this basis, when combined with CrAg, achieved the same diagnostic results as CT‐PNB.…”

Section: Discussionmentioning

confidence: 58%

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Value of rapid on‐site evaluation combined with interventional pulmonology techniques in the diagnosis of pulmonary cryptococcosis

Cao,

Zhou,

et al. 2024

Clinical Respiratory J

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ObjectivesThe aim of this study is to evaluate the diagnostic value of rapid on‐site evaluation (ROSE) combined with computed tomography‐guided percutaneous needle biopsy (CT‐PNB) or radial endobronchial ultrasound‐guided transbronchial lung biopsy (EBUS‐TBLB) for pulmonary cryptococcosis (PC).MethodsClinical data of 33 patients diagnosed with PC at the Third Affiliated Hospital of Soochow University between February 2018 and June 2023 were retrospectively analysed. Patients were divided into the CT‐PNB and EBUS‐TBLB groups based on the intervention method, and the diagnostic positivity rate and incidence of complications were compared between the two groups.ResultsCompared with the final diagnosis, the positive diagnostic rates of ROSE, histopathology and serum CrAg of all patients were 81.8% (27/33), 72.7% (24/33) and 63.6% (21/33), respectively. The average turnaround times of the three methods were 0.1 (0.1–0.2) h, 96.0 (48.0–120.0) h and 7.8 (4.5–13.6) h, respectively (P < 0.001). The coincidence rate between histopathology and ROSE was 84.8% with a kappa value of 0.574. The positive diagnostic rate for PC was significantly higher in the CT‐PNB group than in the EBUS‐TBLB group (92.9% vs. 57.9%), and the difference was statistically significant (P < 0.05). Combined with the ROSE results, the positive diagnostic rate in the EBUS‐TBLB group increased to 84.2% (16/19).ConclusionROSE has commendable accuracy and timeliness, and CT‐PNB offers further advantages in this regard. ROSE enhances the diagnostic efficiency of EBUS‐TBLB for PC and is safe and effective.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 58%

Value of rapid on‐site evaluation combined with interventional pulmonology techniques in the diagnosis of pulmonary cryptococcosis

Cao,

Zhou,

et al. 2024

Clinical Respiratory J

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“…According to a study of cytological specimens using EBUS-TBNA, well-formed non-necrotising granulomas were noted in 90% of the patients with sarcoidosis (38/42 patients), and the remaining 4 patients had poorly formed granulomas. The extent of granulomas was as follows: Rare, occasional, and numerous in 26, 36 and 38% of the patients, respectively (9). High sensitivity (>85%) of EBUS-TBNA in patients with a high clinical suspicion of sarcoidosis has also been reported (10).…”

Section: Discussionmentioning

confidence: 96%

Usefulness and problems of cytological examination by endobronchial ultrasound‑guided transbronchial needle aspiration in the diagnosis of mediastinal lymphadenopathy: A retrospective single‑centre study

et al. 2021

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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and useful technique for sampling mediastinal lymph nodes. High sensitivity and specificity of EBUS-TBNA in staging lung cancer have been reported. However, few studies have addressed the results of EBUS-TBNA in the diagnosis of mediastinal lymphadenopathy with or without lung cancer, since various neoplastic and non-neoplastic conditions can involve the mediastinal lymph nodes. The present study analysed the results of the cytological examination of mediastinal lymphadenopathy using EBUS-TBNA in Kansai Medical University Hospital (Hirakata, Japan). A total of 41 consecutive patients with mediastinal lymphadenopathy who underwent EBUS-TBNA between January 2008 and December 2019 in Kansai Medical University Hospital were enrolled. This cohort included 29 males and 12 females. Cytological analyses demonstrated that 16/17 (94.1%) patients with metastatic carcinoma were diagnosed as having carcinoma (malignancy). The sensitivity, specificity and positive predictive value of the cytological examination in cases of carcinoma were 94.1, 100 and 100, respectively. However, only 3/11 (27.3%) patients with sarcoidosis were diagnosed by cytological examination. The present study demonstrated that EBUS-TBNA may be a useful method for detecting metastatic carcinoma in the mediastinal lymph nodes. However, the detection rate of epithelioid granuloma, which is a characteristic feature of sarcoidosis, was low in the present cohort. Hence, an improvement in the sampling technique is necessary.

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“…The evaluation of mediastinal lymphadenopathy by EBUS‐guided FNA has increased as the procedure has proven to be safe and diagnostic. A recent study by Odronic et al explored rapid on site evaluation and diagnosis of granulomas from EBUS‐guided FNA. They found that 54% of cases found to have granulomas were diagnosed as sarcoidosis.…”

mentioning

confidence: 99%

Asteroid bodies in EBUS‐FNA cytology

Kallas

Ganesan

2014

Diagnostic Cytopathology

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Utility and morphologic features of granulomas on rapid on-site evaluation of endobronchial ultrasonography-guided fine-needle aspiration

Cited by 4 publications

References 18 publications

Value of rapid on‐site evaluation combined with interventional pulmonology techniques in the diagnosis of pulmonary cryptococcosis

Value of rapid on‐site evaluation combined with interventional pulmonology techniques in the diagnosis of pulmonary cryptococcosis

Usefulness and problems of cytological examination by endobronchial ultrasound‑guided transbronchial needle aspiration in the diagnosis of mediastinal lymphadenopathy: A retrospective single‑centre study

Asteroid bodies in EBUS‐FNA cytology

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