Utility and cost of low‐vacuum reinfusion drains in patients undergoing surgery for subcapital hip fracture repair. A before and after cohort study

Abstract

In SHF patients with admission Hb < 13 g/dl and managed with peri-operative IV iron ± recombinant erythropoietin plus restrictive transfusion indication, the use of Bellovac ABT was associated with reduced ABT requirements, without increasing postoperative complications, and cost-savings.

Evaluation of the uptake, storage and cell effects of nano-iron in enterocyte-like cell models

“…Ferritin concentration was obtained by using a previously developed ICP-MS linked immunoassay based on a sandwich experiment with a Ru-labelled antibody [16]. The obtained results are shown in Fig.…”

“…4. Ferritin concentration obtained in the HT-29 cells treated with the three Fe-containing compounds (500 µM as Fe) and measured using an ICP-MS based sandwich immunoassay [16].…”

“…In this regard, Fe(III)-sucrose complex (Venofer®) contains an Fe(III) core surrounded by sucrose that provides a negative charge on the NPs outer shell. This complex is commonly used in intravenous iron formulations and has provided lower anaphylactic reactions in patients that soon after administration recover the adequate iron values in circulating blood [16]. Thus, the aim of this work is the comparative evaluation of these two types of FeONPs (sucrose coated and ferritin encapsulated) regarding enterocytes uptake and management.…”

Stimulating erythropoiesis before hip fracture repair for reducing blood transfusion: should we change the hemoglobin cutoff level for defining anemia in females?

“…At present, data are inconclusive, especially in terms of safety . One option, low vacuum drains, has only been reported in observational studies on subcapital HF . In contrast, very short‐term stimulation of erythropoiesis with intravenous (IV) iron, with or without recombinant human erythropoietin (EPO), has been shown to reduce ABT requirements in two randomized trials and a large observational study …”

“…9,10 One option, low vacuum drains, has only been reported in observational studies on subcapital HF. 11 In contrast, very short-term stimulation of erythropoiesis with intravenous (IV) iron, with or without recombinant human erythropoietin (EPO), has been shown to reduce ABT requirements in two randomized trials 12,13 and a large observational study. 14 In this issue of TRANSFUSION, Bernabeu-Wittel and colleagues 15 reported on the results of a multicenter, randomized, double-blinded, clinical trial, assessing efficacy of ferric carboxymaltose (FCM) with or without EPO in reducing ABT perioperatively after HF repair.…”