“…IHS with nitrous oxide has been at the helm of sedation in dentistry for more than 170 years, but recently there has been a major call for more robust evidence to back its use generally and in dental practice. [17,20] Nevertheless, IHS use has contemporarily been strongly recommended by major organizations that champion the dental welfare of children globally. For example, the American Academy of Pediatric Dentistry (AAPD) recognizes nitrous oxide/oxygen inhalation as a safe and effective technique to reduce anxiety, produce analgesia, and enhance effective communication between a patient and health care provider (AAPD 2015).…”