Utilisation of antimicrobial photodynamic therapy as an adjunctive tool for open flap debridement in the management of chronic periodontitis: A randomized controlled clinical trial

Dalvi, Snehal; Hanna, Reem; Gattani, Deepti

doi:10.1016/j.pdpdt.2019.01.023

Cited by 12 publications

(4 citation statements)

References 43 publications

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“…[ 27 ] In cases where there is no clinical attachment gain, open flap debridement along with laser-assisted treatment has shown significant improvements in experimental and chronic periodontitis cases. [ 66 ]…”

Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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A BSTRACT Objective: The purpose of the study is to evaluate the various lasers in dentistry and to investigate if it can be used for treatment of refractory periodontitis. Methods: The study followed partially the PRISMA guidelines as it is a narrative review. A number of articles were selected from a period of 1980 to 2020 from databases, PubMed, PubMed central, Cochrane and Scopus. Articles related to the effects of lasers on periodontitis both refractory and aggressive were investigated. Results: After reviewing the literature, 70 articles were found, related to application of lasers in periodontal diseases. Out of the 70, 11 articles pertained to the effect of laser for the treatment of Refractory and inflammatory periodontitis. 5 articles related to experimental animal models, one pertaining to in-vitro and six studies related to in-vivo in human cohorts. Discussion: It was found that lasers if used in controlled parameters by incorporating laser assisted treatment such as Photodynamic therapy and low level laser therapy can be of use as an adjunct therapy for treatment of refractory periodontitis. The use of different wavelengths in the initial and maintenance phase of periodontal disease plays a positive role. The presence of in-vitro and animal model studies is one of the limitation to this study. The available studies have shown marked reduction in inflammation and better clinical and microbiological parameters. The drawback of this study is the limited literature involving laser management for refractory periodontitis in human cohorts. Conclusion: Different wavelengths of laser and choice of laser assisted periodontal treatment plays an important role in the overall progress and prognosis of periodontal disease activity.

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Section: Discussionmentioning

confidence: 99%

Applications of lasers in refractory periodontitis: A narrative review

Varma

AlShayeb

Narayanan

et al. 2020

J Int Soc Prevent Communit Dent

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“…In most studies, applying APDT after SRP improved microbiological and clinical parameters in chronic periodontitis, as shown in Table 3 (Figures 3 and 4) [116–118, 120, 121, 123, 124, 128, 143–149]. Using the same patient before and after APDT treatment, Freitas et al [114] assessed the correlation between clinical parameters in periodontitis sites.…”

Section: The Antimicrobial Effect Of Photodynamic Therapymentioning

confidence: 99%

The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

Aghili,

Jahangirnia,

Alam

et al. 2023

J Basic Microbiol

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Several resistance mechanisms are involved in dental caries, including oral biofilms. An accumulation of bacteria on the surface of teeth is called plaque. Periodontitis and gingivitis are caused by dental plaque. In this review article, we aimed to review the studies associated with the application of photodynamic therapy (PDT) to prevent and treat various microbial biofilm‐caused oral diseases in recent decades. There are several studies published in PubMed that have described antimicrobial photodynamic therapy (APDT) effects on microorganisms. Several in vitro and in vivo studies have demonstrated the potential of APDT for treating endodontic, periodontal, and mucosal infections caused by bacteria as biofilms. Reactive oxygen species (ROS) are activated in the presence of oxygen by integrating a nontoxic photosensitizer (PS) with appropriate wavelength visible light. By causing irreversible damage to microorganisms, ROS induces some biological and photochemical events. Testing several wavelengths has been conducted to identify potential PS for APDT. A standard protocol is not yet available, and the current review summarizes findings from dental studies on APDT.

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“…Studies have shown that PBMt is capable favoring the transformation of macrophages into M2 phenotype which alleviate inflammation and promotes tissue repair and remodeling. 1,26 Current literature regarding the use of PBMt for bone regeneration is mainly sourced from orthodontic applications reporting the suitability of the procedure for reducing pain and inflammation, 26,27 periodontitis management, 26,28 and bone remodeling during tooth movement. 29,30 However, independent studies are still being conducted regarding the use of PBMt for regenerating critical sized bone defects in animal models, [31][32][33] enhancing results of distraction osteogenesis, 34,35 regenerating irradiated bone, 36 repair bone lesions, 37 manage osteoporosis, 38,39 and resolve osteonecrosis.…”

Section: Photobiomodulation Therapy (Pbmt) For Bone Regenerationmentioning

confidence: 99%

Brief Retrospect on the Use of Photobiomodulation (PBM) Therapy for Augmented Bone Regeneration (ABR)

Padalhin

2021

Medical Lasers

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As technology advances at a rapid rate, innovations in regenerative medicine will eventually include the use of energy-based therapeutics, such as low intensity-pulsed ultrasound stimulation (LIPUs), pulsed electromagnetic field stimulation (PMFs), and low-level laser/light therapy (LLLt) or photobiomodulation therapy (PBMt). Among these treatments, LLLt/PBMt attracted significant attention by the turn of the century, as evidenced by the numerous publications compared to LIPUs and PMFs, particularly for augmented bone regeneration (ABR). This is a testament of how the maturation of technology and scientific knowledge leads to latent compounded applications, even when the value of a technique is reliant on empirical data. This article reviews some of the notable investigations using LLLt/PBMt for bone regeneration published in the past decade, focusing on how this type of therapy has been utilized together with the existing regenerative medicine landscape.

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Utilisation of antimicrobial photodynamic therapy as an adjunctive tool for open flap debridement in the management of chronic periodontitis: A randomized controlled clinical trial

Cited by 12 publications

References 43 publications

Applications of lasers in refractory periodontitis: A narrative review

Applications of lasers in refractory periodontitis: A narrative review

The effect of photodynamic therapy in controlling the oral biofilm: A comprehensive overview

Brief Retrospect on the Use of Photobiomodulation (PBM) Therapy for Augmented Bone Regeneration (ABR)

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