Utilidad del Quantiferon-TB Gold in Tube® en el cribado de la infección latente tuberculosa en personal sanitario

Martínez-Lacasa, Xavier; Font, Roser; González, Susana Álvarez; Sallent, Sonia; Jaén, Àngels; Lite, Josep; Cuchí, Eva

doi:10.1016/j.eimc.2014.11.006

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…32,33 However, as IGRAs remains an expensive test, other studies recommend the use of sequential strategies (using TT and IGRAs) for the diagnosis of LTBI. 34,35 One case of active, noncontagious TB was diagnosed (0.3%), which is the same as or even lower than the rate observed in the immigrant population in other series (0-6%). [7][8][9][10] The presence of intestinal parasites was similar to or lower than that observed in other migrant series (2-39%).…”

Section: Discussionsupporting

confidence: 48%

Health Status of Asylum Seekers, Spain

Serre-Delcor

Ascaso

Soriano‐Arandes

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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The rising rate of conflicts and the unsafe situation caused by reasons of ethnicity, religion, gender, sexual orientation, political opinion, or nationality entail an increase in the number of migratory movements. The goal of this article is to describe the health status of asylum seekers visited in an international health center. We conducted a retrospective study of the asylum seekers visited between July 2013 and June 2016. A total of 303 cases were included. The median age was 28.0 years (interquartile range [IQR]: 21-35), and 203 (67.0%) were men. Of the total, 128 cases (42.2%) were from Asia, 82 (27.1%) from Eastern Europe, 42 (13.9%) from sub-Saharan Africa, 34 (11.2%) from America, and 17 (5.6%) from Maghreb. The majority, 287 (94.7%), were asymptomatic. Seventy of the 303 (23.1%) cases were diagnosed with at least one infection, this being more prevalent in men; migrants from sub-Saharan Africa; and in those who took a land-maritime migratory route. Eight of the 303 (2.6%) cases were referred to the transcultural psychiatric department. Two important challenges of the study were the communication barriers and the legal or social situation that condition the psychological symptoms. In 48 of the 303 (15.8%) cases, there was diagnosed a noncommunicable diseases. The process of care was completed by 82.5%; although 21.9% completed the vaccination for hepatitis B. The asylum seekers in this study were in general healthy young men, although special attention was given to infectious diseases with certain geoepidemiological backgrounds. Unstable living arrangements, linguistic, and cultural barriers could account for the failure of the course of care.

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Section: Discussionsupporting

confidence: 48%

Health Status of Asylum Seekers, Spain

Serre-Delcor

Ascaso

Soriano‐Arandes

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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“…Taking into account positive TST or IGRA results, the prevalence of infection found in this study was 31.4% and 12.5%, respectively. This prevalence is similar to that found in other studies carried out in Catalonia [17,18] and also in other studies that describe this data in countries of low and intermediate income [2,19,20]. Factors associated with the positivity of either TST or IGRA test were BCG vaccination status and degree of occupational exposure to tuberculosis.…”

Section: Plos Onesupporting

confidence: 91%

Serial testing of health care workers for tuberculosis infection: A prospective cohort study

et al. 2020

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Health Care Workers (HCW) may have an occupational risk of latent tuberculosis infection (LTBI) and TB disease. The objective of this study was to evaluate the performance of the 2step strategy: tuberculin skin test (TST) followed by confirmation with Interferon (IFN)-γrelease assays (IGRAs) in HCW. A secondary objective was to determine the factors related to conversions and reversions. HCW at risk of occupational exposure who attended the Occupational Department of the Hospital Germans Trias i Pujol were included during the study period (2013-2016). All professionals testing negative for LTBI were included in a cohort study. These workers were followed up with the administration of a TST and an IGRA quantification at least one year after inclusion in the study. Workers with positive TST, regardless of the results of the IGRA tests, were followed-up with an IGRA. 255 workers were enrolled in the study and 108 workers from the same cohort were followed up. During the follow-up period, seven workers presented TST test conversion. One of these conversions was also confirmed by an IGRA test. There were 2 conversions of cases only testing positive with the IGRA. There have been only 2 reversions of cases testing negative with the IGRA. In this study, not all TST conversions were confirmed when using the IGRA test, which highlights the importance of the 2-step strategy. We have detected a low number of conversions and reversions. Our conclusions should be confirmed in studies with a longer follow-up time.

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“…Medical personnel who work with TB patients are exposed to TB and run a higher risk of catching it than the general public. A study published in our centre showed a prevalence of 14.6% 16 . A study published in Montreal on non-medical personnel working in high-risk hostels and prisons showed that prevalence was similar to levels in medical staff 17 .…”

Section: Screening Of Latent Tuberculosis Infection In High Risk Groupsmentioning

confidence: 72%

Guidelines on controlling latent tuberculosis infection to support tuberculosis elimination

Godoy¹

2021

Rev Esp Sanid Penit

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Objectives: Latent TB infection (LTBI) affects 25% of the world’s population. As long as this reservoir exists, the elimination of TB will not be feasible. The Assembly of the World Health Organization adopted the “Global End TB” strategy for the elimination of TB in 2014. The objective of this review is to present strategies for risk groups that are candidates for the detection and treatment of LTBI. Material and method: There is sufficient evidence of screening in: immunocompromised people (HIV-infected, biological therapies, alternative renal therapy, organ transplantation), recent immigrants, inmates in prison, people injecting drugs and homeless people, and workers from at-risk settings. Tests to diagnose LTBI include tuberculin skin test (TST) and gamma release assay interferon (IGRA). There is no reference test and the choice of one or the other will depend on logistical considerations, such as avoiding injection (TST) or not needing a second visit (IGRA). Treatment of LTBI is based on the use of isoniazide and rifampicin in short period of 3 or 4 months, using associations of rifampicin and isoniazide or rifampicin alone. Discussion: Given the estimated high prevalence of LTBI, renewed efforts are required to reduce the number of people with LTBI that includes a registration and monitoring system to observer progress, increased testing, and the use of short treatment guidelines.

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Utilidad del Quantiferon-TB Gold in Tube® en el cribado de la infección latente tuberculosa en personal sanitario

Cited by 6 publications

References 39 publications

Health Status of Asylum Seekers, Spain

Health Status of Asylum Seekers, Spain

Serial testing of health care workers for tuberculosis infection: A prospective cohort study

Guidelines on controlling latent tuberculosis infection to support tuberculosis elimination

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