Utilidad de medicamentos intranasales en urgencias

Abstract

Financiamiento: Propia. Conflicto de intereses: Los autores declaran no tener ningún conflicto de interés. Fecha de recepción: 21 de febrero de 2023 / Fecha de aceptación: 12 de abril de 2023 ABASTRACT Introduction: Given the scenarios of care in critical patients in the emergency room, the administration of medications is required quickly, especially in patients with mental disturbance or shock. Intranasal drug administration has been shown to be a viable alternative for the management of critically ill adult and pediatric patients; and in some situations, in which there may be some limitation for the administration of oral medications. Objetive: To know the mechanism of bioavailability and the pharmacological options for the administration of intranasal drugs in emergency room. Methods: Search for meta-analyses, systematic reviews, articles and case reports via Cochrane, PubMed, ScienceDirect, EBSCO. Results: Intranasal administration absorption depends on several factors, the most important being the placement of the drug and the rate of mucociliary clearance. Unlike the intravenous route, intranasal administration does not require sterile access, this generates greater speed in the preparation and administration of medications. There is a variety of medications and methods for the application of medications, including analgesics, inducers, sedatives, anesthetics, and some still under investigation. Conclusion: The intranasal route may be an option in situations in which timely administration of medications is required and appropriate dose selection in relation to the administered drug.