Uterus Recovery from Deceased Donor: Simple Technique Securing Safety of Vital Organs and Uterus Graft

D’Amico, Giuseppe; Quintini, Cristiano; Eghtesad, Bijan; Hashimoto, Koji; Ricci, Stephanie; Flyckt, Rebecca; Prete, Luca Del; Miller, Charles M.; Falcone, Tommaso; Tzakis, Andreas G.

doi:10.1016/j.jamcollsurg.2020.11.007

Cited by 10 publications

(14 citation statements)

References 22 publications

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“…The largest report of uterus retrieval was performed by the Cleveland team, with 20 cases. They used eight of them for transplant and reported two births [20]. They also do the uterus retrieval after all vital organs harvest, performing inguinal incisions, sectioning ureters on the first steps of surgery, and doing the perfusion cannulating just in one external iliac artery.…”

Section: Discussionmentioning

confidence: 99%

“…Differences between techniques of uterus retrieval around the world in specific points are shown in Table 3. We could not assure which one was better, but we can see positive outcomes in trials made in Cleveland, Dallas, Brazil, and Czech Republic who performed in 18 transplants using dead donors and achieved five births [18–20]. Perhaps, these different experiences complement each other, and we are convinced that sharing all these experiences will improve future outcomes in this modality of transplant.…”

Section: Discussionmentioning

confidence: 99%

“…The second successful transplantation from a deceased donor was reported by a team from Cleveland in 2019 [14]. So far, reports of transplants have been published in several countries, 18 cases involving deceased donors (resulting in five births) [14–20].…”

Section: Introductionmentioning

confidence: 99%

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Uterus procurement from deceased donor for transplantation

Castro

Ejzenberg

Pinheiro

et al. 2021

Transplant International

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Summary Women with absolute uterine factor infertility cannot get pregnant. The current experience in uterine transplantation is limited and the use of a deceased donor uterus in this area is incipient after some initial unsuccessful attempts. The birth of healthy babies through this modality in four different centers has given a new impetus to the use of this transplantation technique. We aimed to develop a technique for uterus procurement and preparation for transplantation from a brain dead donor. Fifteen uteri were retrieved from multi‐organ donor patients, 10 of these were used in bench surgeries with the proposed technique. All procedures were performed after obtaining family's consent. This study allowed the clinical use of two of the 15 organs that were procured for transplantation. One of these organs resulted in the first live birth worldwide using a uterus transplanted from a deceased donor, a landmark in reproductive medicine. Another outcome was the optimization of the surgical technique involving less manipulation of the uterine vascular pedicles. The success of this novel technique suggests that the proposed model can be replicated and optimized further to facilitate the transplantation of uterus from deceased donors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Uterus procurement from deceased donor for transplantation

Castro

Ejzenberg

Pinheiro

et al. 2021

Transplant International

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“…minology codes, 5 developing novel surgical techniques for deceased donor (DD) [8][9][10] and fully robotic living donor (LD) hysterectomies, 11 allowing early embryo transfer (ET), 12 and using the superior uterine veins for graft survival and live birth (LB). 13,14 Since the first US uterus transplant at CCF in 2016 and the first LB at BUMC in 2017, to our knowledge, there has yet to be a comprehensive report examining the 33 uterus transplant and 21 LBs performed in the US.…”

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confidence: 99%

The First 5 Years of Uterus Transplant in the US

et al. 2022

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terus transplant is a treatment for women affected by absolute uterine-factor infertility (AUFI), previously considered untreatable. AUFI is a major cause of female infertility, reported to affect 1 in 500 women. 1,2 Primary care clinicians are typically the front line of care when AUFI is suspected or diagnosed. Given the lifeframing nature of the diagnosis, appropriate counseling is challenging. Many are told that family-building options are limited to use of a gestational carrier or adoption. 3 Uterus transplant uniquely restores reproductive ability and enables gestation and childbirth. 4 Increased data regarding outcomes following uterus transplant are essential to coun-sel individuals with AUFI to evaluate all available pathways to parenthood.The United States Uterus Transplant Consortium (USUTC)

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“…Flyckt, Richards, D'Amico et al (26)(27)(28)(29) , da Cleveland Clinic, citam a importância de uma equipe multidisciplinar estar em um centro que tenha capacidade tecnológica e recurso humano para realizar o projeto com sucesso. Descrevem sua experiência de nove transplantes com doadora falecida, o primeiro deles, como foi descrito anteriormente, houve trombose vascular por cândida; o segundo transplante, foi realizado em 2017 o útero foi retirado antes dos outros órgãos, na fase quente, e lavado ex situ, esta série tem o nascimento de dois bebês saudáveis.…”

Section: Discussionunclassified

Padronização da captação de útero e cirurgia de bancada de doadora falecida para transplante

Villegas¹

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quem abriu a porta a um caminho de formação que mudou minha vida e deu-me a oportunidade de ter hoje o orgulho de ter feito minha formação em transplante no Hospital das Clínicas. Ao Prof. Wellington Andraus, quem foi meu guia e exemplo de humildade e profissionalismo, quem teve a paciência interminável de dar orientação e conselho sempre que precisei. Ao Prof. Dani Ejzenberg, quem fez as vezes de orientador, contei sempre com seu apoio incondicional, sempre teve a melhor disposição para me ajudar e aconselhar-me. Ao Dr. Rafael Pinheiro que, além de ser meu exemplo de profissional, com quem aprendi em todo momento e quem também me ajudou no processo deste projeto e apresentou-me sua amizade. A toda equipe do Departamento Transplante de fígado e órgãos do aparelho digestivo que me fizeram sentir sempre em casa. Ao Serviço de Transplante de Fígado da Clínica Imbanaco quem acreditou em mim, e permitiu fazer parte desta tese. A meus pais Fernando Castro e Olga Villegas, e irmãos Juliana Castro e Manuel Castro, que sempre me ensinaram o valor da verdade e a importância de ajudar a quem precisa. A minha esposa Linda Gutierrez e meus filhos Samuel e Paulina Castro, que todos os dias fazem que eu acredite que tudo é possível na vida, e são a inspiração de minha vida. v "Quando o objetivo não pode ser alcançado, não mude o objetivo, mude os passos" Confucio vi NORMALIZAÇÃO ADOTADA Esta tese está de acordo com as seguintes normas, em vigor no momento desta publicação: Referências adaptado de International Committee of Medical Journals Editors (Vancouver).

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Uterus Recovery from Deceased Donor: Simple Technique Securing Safety of Vital Organs and Uterus Graft

Cited by 10 publications

References 22 publications

Uterus procurement from deceased donor for transplantation

Uterus procurement from deceased donor for transplantation

The First 5 Years of Uterus Transplant in the US

Padronização da captação de útero e cirurgia de bancada de doadora falecida para transplante

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