Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy

Pijnenborg, Robert; Bland, J. M.; Robertson, W. B.; Brosens, Ivo

doi:10.1016/s0143-4004(83)80043-5

Cited by 640 publications

(355 citation statements)

References 10 publications

Supporting

Mentioning

334

Contrasting

Unclassified

Order By: Relevance

“…1) (Aplin, 1991;Pijnenborg et al, 1983). This will lead directly to the poor uterine artery blood flow, as detected by ultrasound Doppler velocimetry measurements, in FGR (Cnossen et al, 2008;Karsdorp et al, 1994).…”

Section: Blood Flowmentioning

confidence: 99%

“…This will lead directly to the poor uterine artery blood flow, as detected by ultrasound Doppler velocimetry measurements, in FGR (Cnossen et al, 2008;Karsdorp et al, 1994). This failed invasion and transformation may also be the root cause of abnormal placental development in FGR as well as other pregnancy complications such as pre-eclampsia (Aplin, 1991;Pijnenborg et al, 1983). One effect of this abnormal placental development is malformation of the fetoplacental vascular bed of the umbilical circulation (Kingdom et al, 2000).…”

Section: Blood Flowmentioning

confidence: 99%

See 1 more Smart Citation

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

140

View full text Add to dashboard Cite

This review considers mechanisms by which transfer across the placenta takes place and how the capacity of the placenta to supply nutrients relates to fetal growth and vice versa. Blood flow through both uterine and umbilical circulations of the placenta, the structural properties of the placental exchange barrier and its related diffusional permeability, and the expression and activity of a wide range of transporter proteins in the syncytiotrophoblast, the transporting epithelium of the placenta, all need to be taken into account in considering placental supply capacity. We discuss the evidence that each of these factors affects, and is affected by, fetal growth rate and consider the regulatory mechanisms involved, with a particular focus on data that has emerged from study of the system A amino acid transporter. We consider that future work will build on the considerable foundation of knowledge regarding placental transfer mechanisms, as well as the other aspects of placental structure and function, to develop new diagnostic and therapeutic strategies for pregnancy complications, such as fetal growth restriction or overgrowth.

show abstract

Section: Blood Flowmentioning

confidence: 99%

Section: Blood Flowmentioning

confidence: 99%

Placental nutrient supply and fetal growth

Desforges¹,

Sibley²

2010

Int. J. Dev. Biol.

140

View full text Add to dashboard Cite

show abstract

“…Moreover, the expressions of both CYP25B1 (the vitamin D activating enzyme) and vitamin D nuclear receptor (10) are highest during the first trimester. In the current study, factors that may alter the development of pregnancy conditions were investigated at the beginning of the second trimester -a time when critical vascular development of the placenta occurs (11) .The aim of this study was to investigate the relationship between early pregnancy 25-hydroxyvitamin D concentration and subsequent development of pre-eclampsia, spontaneous preterm birth, SGA and GDM in a large, well-phenotyped, prospective cohort. …”

mentioning

confidence: 99%

The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

et al. 2016

View full text Add to dashboard Cite

Type of publicationArticle (peer-reviewed)Link to publisher's version http://dx.doi.org/10.1017/S0007114516003202Access to the full text of the published version may require a subscription. Rights © The Authors 2016Embargo information Access to this article is restricted until 12 months after publication by the request of the publisher Abstract Vitamin D insufficiency and deficiency have been associated with an increased risk of adverse pregnancy outcomes. Controversy remains as findings have been inconsistent between disparate populations. The aim of this study was to investigate the relationship between vitamin D status and pregnancy outcomes in a large, prospective pregnancy cohort. 25-Hydroxyvitamin D concentration was analysed in serum samples collected at 15 weeks of gestation from 1710 New Zealand women participating in a large, observational study. Associations between vitamin D status and pre-eclampsia, preterm birth, small for gestational age (SGA) and gestational diabetes were investigated. The mean 25-hydroxyvitamin D concentration was 72·9 nmol/l. In all, 23 % had 25-hydroxyvitamin D concentrations <50 nmol/l, and 5 % of participants had concentrations <25 nmol/l. Women with 25-hydroxyvitamin D concentrations <75 nmol/l at 15 weeks of gestation were more likely to develop gestational diabetes mellitus than those with concentrations >75 nmol/l (OR 2·3; 95 % CI 1·1, 5·1). However, this effect was not significant when adjustments were made for BMI and ethnicity (OR 1·8; 95 % CI 0·8, 4·2). 25-Hydroxyvitamin D concentration at 15 weeks was not associated with development of pre-eclampsia, spontaneous preterm birth or SGA infants. Pregnancy complications were low in this largely vitamin D-replete population.Key words: Vitamin D: Gestational diabetes mellitus: Pre-eclampsia Much progress has been made in the screening, diagnosis and management of important pregnancy disorders, but little progress has been made in the prevention of such disorders. Preeclampsia remains the second most common cause of maternal death worldwide (1) . Prematurity, mostly due to spontaneous preterm birth, is the leading cause of death among infants worldwide (2) . This is followed by growth restriction in term infants (3) . Furthermore, infants born preterm or with low birth weight have an increased risk of CVD and metabolic diseases later in life, the leading cause of death in adulthood (4) . The incidence of gestational diabetes mellitus (GDM) is increasing rapidly worldwide (5) and is associated with lifelong risks of metabolic disease in both mother and baby (6,7) . An association between low vitamin D and adverse pregnancy outcomes was first identified in the early 2000s (8) ; consequently, vitamin D has been postulated as a possible intervention strategy to reduce pregnancy complications. A recent meta-analysis found that low vitamin D, defined variably by the authors of included studies, was associated with an increased likelihood of pre-eclampsia (OR 1·79; 95 % CI 1·25, 2·58), small-for-gestational age (SGA) babies (OR 1·...

show abstract

“…[1][2][3] Hemochorial placentation requires trophoblast cell invasion into uterine tissue, which is associated with remodeling of uterine spiral arteries. 4 Both trophoblast cell invasion and spiral artery remodeling are key steps to allow optimal gas exchange and nutrient supply to the developing fetus. In the human, failure of these processes may result in intrauterine growth restriction and preeclampsia.…”

mentioning

confidence: 99%

Natural Killer Cell Reduction and Uteroplacental Vasculopathy

et al. 2016

View full text Add to dashboard Cite

Abstract-Uterine natural killer cells are important for uteroplacental development and pregnancy maintenance. Their role in pregnancy disorders, such as preeclampsia, is unknown. We reduced the number of natural killer cells by administering rabbit anti-asialo GM1 antiserum in an established rat preeclamptic model (female human angiotensinogen×male human renin) and evaluated the effects at the end of pregnancy (day 21), compared with preeclamptic control rats receiving normal rabbit serum. In 100% of the antiserum-treated, preeclamptic rats (7/7), we observed highly degenerated vessel cross sections in the mesometrial triangle at the end of pregnancy. This maternal uterine vasculopathy was characterized by a total absence of nucleated/living cells in the vessel wall and perivascularly and prominent presence of fibrosis. Furthermore, there were no endovascular trophoblast cells within the vessel lumen. In the control, normal rabbit serum-treated, preeclamptic rats, only 20% (1/5) of the animals displayed such vasculopathy. We confirmed the results in healthy pregnant wild-type rats: after anti-asialo GM1 treatment, 67% of maternal rats displayed vasculopathy at the end of pregnancy compared with 0% in rabbit serum-treated control rats. This vasculopathy was associated with a significantly lower fetal weight in wild-type rats and deterioration of fetal brain/liver weight ratio in preeclamptic rats. Anti-asialo GM1 application had no influence on maternal hypertension and albuminuria during pregnancy. Our results show a new role of natural killer cells during hypertensive pregnancy in maintaining vascular integrity. In normotensive pregnancy, this integrity seems important for fetal growth. (Hypertension. 2016;68:964-973.

show abstract

Uteroplacental arterial changes related to interstitial trophoblast migration in early human pregnancy

Cited by 640 publications

References 10 publications

Placental nutrient supply and fetal growth

Placental nutrient supply and fetal growth

The relationship between 25-hydroxyvitamin D concentration in early pregnancy and pregnancy outcomes in a large, prospective cohort

Natural Killer Cell Reduction and Uteroplacental Vasculopathy

Contact Info

Product

Resources

About