Uterine vascularization and pregnancy outcome in patients undergoing intracytoplasmatic sperm injection: The role of nitric oxide

Battaglia, Cesare; Persico, Nicola; Mancini, Fulvia; Iaco, Pierandrea De; Busacchi, Paolo; Facchinetti, Fabio; Aloysio, Domenico De

doi:10.1007/s10815-006-9049-x

Cited by 4 publications

(5 citation statements)

References 45 publications

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“…Methods to preserve fertility are now available in many centers, but reduced uterine volume and inappropriate uterine blood supply in these patients have been linked to poor outcomes even during assisted reproduction therapies (13)(14)(15)(16)(17).…”

mentioning

confidence: 99%

Adolescent and adult uterine volume and uterine artery Doppler blood flow among subjects treated with bone marrow transplantation or chemotherapy in pediatric age: a case-control study

Beneventi

Locatelli

Giorgiani

et al. 2015

Fertility and Sterility

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mentioning

confidence: 99%

Adolescent and adult uterine volume and uterine artery Doppler blood flow among subjects treated with bone marrow transplantation or chemotherapy in pediatric age: a case-control study

Beneventi

Locatelli

Giorgiani

et al. 2015

Fertility and Sterility

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“…Among other molecules, FF contains free radicals, like NO, which is actively synthesized by the granulosa cells (Lee et al, 2000). This means that NO and/or its by-products may be potential biomarkers for IVF outcome, and several studies tested this hypothesis in patients undergoing fertility treatment (Barroso et al, 1999;Barrionuevo et al, 2000;Lee et al, 2000;Battaglia et al, 2006;Vignini et al, 2008;Zhao et al, 2010;Goud et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…On one hand, evidence suggests that NO levels in the follicular fluid (FF) are inversely associated with the fertilization of mature oocytes and the ability of the subsequent embryo to cleave normally (Barrionuevo et al, 2000). Furthermore, a negative correlation between FF NO levels and embryo morphology was identified (Barroso et al, 1999;Battaglia et al, 2006). On the other hand, other studies found no differences in relation to oocyte and embryo quality (Lee et al, 2000;Yalçınkaya et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Nitrite and Nitrate Levels in Follicular Fluid From Human Oocyte Donors Are Related to Ovarian Response and Embryo Quality

Staicu

Canha-Gouveia

Soriano‐Úbeda

et al. 2021

Front. Cell Dev. Biol.

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Nitric oxide, a key regulatory molecule in the follicular fluid, has been suggested as a possible biomarker to predict ovarian response in stimulated cycles and the potential of the retrieved oocytes for developing high-quality embryos. Nevertheless, a consensus on whether or not nitric oxide can help in this context has not been reached. We simultaneously measured the oxidation products of nitric oxide, nitrite, and nitrate, via high-performance liquid chromatography (HPLC)-UV in follicular fluid samples from 72 oocyte donors. We found no associations of follicular fluid nitrite, nitrate, total nitric oxide, or nitrate/nitrite ratio with total or metaphase II (MII) oocyte yield. However, nitrite and nitrate levels were related to the yield of MII oocytes when this outcome was expressed as a proportion of all oocytes retrieved. The adjusted MII proportion in the lowest and highest nitrite levels were 68% (58–77%) and 79% (70–85%), respectively (p, linear trend = 0.02), whereas the adjusted MII proportion in extreme tertiles of nitrate levels were 79% (70–85%) and 68% (57–77%) (p, linear trend = 0.03). In addition, nitrate levels showed a suggestive inverse correlation with embryos with maximum or high potential of implantation (p = 0.07). These results suggest that the follicular fluid concentrations of nitrite and nitrate may be a useful tool in predicting how healthy oocyte donors respond to superovulation and the implantation potential of the embryos produced from their oocytes.

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“…Ultrasound-based diagnostics have been in use since the 1940s. Whereas conventional ultrasound can visualize two-dimensional (2D) sections, modern three-dimensional (3D) ultrasound can provide additional information such as volume and orthogonal plane metrics ( 1 ). Doppler ultrasonographic methods measure the change in ultrasound pulse when it is reflected by an object having some velocity in the beam’s direction ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…Transvaginal Doppler ultrasonography has advanced the pathophysiological understanding of blood flow dynamics in the female pelvis ( 7 ). It is a useful method of examining the blood flow through the uterus, ovaries, and even in the follicles ( 1 ). Transvaginal Doppler ultrasonography has become an important component of assisted reproduction procedures.…”

Section: Introductionmentioning

confidence: 99%

A comparison of Doppler measures of ovarian blood flow between women with and without ovarian dysfunction and correlations of Doppler indices with ovarian dysfunction markers: a meta-analysis

Wang¹,

Chu²,

Hou³

2023

Ann Transl Med

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Background Doppler ultrasonography is used to study ovarian vascular characteristics. However, the outcomes are reported with a considerable variability in literature. Here we review the differences in Doppler ultrasound-measured ovarian blood flow indices between women with and without ovarian dysfunction and seeks correlations between Doppler measures and ovarian markers. Methods A literature search was conducted in electronic databases (Google Scholar, Ovid, PubMed, Science Direct, and Springer) to identify studies that used Doppler for ovarian blood flow examination and reported Doppler measures in women with and without ovarian dysfunction and/or the correlations between wDoppler indices and markers of ovarian dysfunction. After quality assessment of included studies, a meta-analysis of weighted mean differences (WMDs) between women with and without ovarian dysfunction in vascularization index (VI), flow index (FI), vascularization flow index (VFI), pulsatility index (PI) and resistance index (RI) was performed. Correlation coefficients between Doppler indices and markers of ovarian dysfunction were pooled to achieve overall estimates. Results A total of 27 studies [2,377 women with ovarian dysfunction and 308 controls; age 27.7 years, 95% confidence interval (CI): 26.4 to 29.1] were included. These studies were of moderate quality. The VI (WMD 9.75; P<0.0001), FI (WMD 2.73; P<0.0001), and VFI (WMD 1.29; P<0.0001) were significantly higher whereas PI (WMD −1.08; P=0.001) and RI (WMD −0.26; P<0.0001) were significantly lower in women with polycystic ovarian syndrome (PCOS) than in normal women. In women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), antral follicle count was positively correlated with VI (r=0.24; P=0.001), FI (r=0.42; P<0.0001), and VFI (r=0.25; P=0.002). In women with PCOS, testosterone had statistically non-significant correlations with VI (r=0.40; P=0.081), and VFI (r=0.39; P=0.063) and was inversely correlated with PI (r=−0.30; P<0.0001) and RI (r=−0.48; P<0.0001). In women with PCOS, luteinizing hormone (LH) was inversely correlated with PI (r=−0.26; P=0.086) and RI (r=−0.25; P=0.007). Conclusions Doppler indices are found significantly different in women with and without ovarian dysfunction and have significant correlations with markers of ovarian dysfunction. These results support the use of Doppler ultrasound to examine ovarian dysfunction. High statistical heterogeneity observed herein should be studies in future investigations.

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Uterine vascularization and pregnancy outcome in patients undergoing intracytoplasmatic sperm injection: The role of nitric oxide

Abstract: A Doppler analysis done on day 1 of controlled ovarian hyperstimulation may be an useful indicator of ART outcome.

Cited by 4 publications

References 45 publications

Adolescent and adult uterine volume and uterine artery Doppler blood flow among subjects treated with bone marrow transplantation or chemotherapy in pediatric age: a case-control study

Adolescent and adult uterine volume and uterine artery Doppler blood flow among subjects treated with bone marrow transplantation or chemotherapy in pediatric age: a case-control study

Nitrite and Nitrate Levels in Follicular Fluid From Human Oocyte Donors Are Related to Ovarian Response and Embryo Quality

A comparison of Doppler measures of ovarian blood flow between women with and without ovarian dysfunction and correlations of Doppler indices with ovarian dysfunction markers: a meta-analysis

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