Uterine vascular resistance and other maternal factors associated with the risk of developing hypertension during pregnancy

Martins, Luiz Augusto Beltramin; Veiga, E C A; Ribeiro, Cecília Cláudia Costa; Cardoso, Valtemar Fernandes; Bettiol, Heloísa; Barbieri, Marco Antônio; Cavalli, Ricardo de Carvalho

doi:10.1590/1414-431x202010118

Cited by 6 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Extensive research has led to the identifying several potential biomarkers for the detection of preeclampsia 63 , 64 , 65 , 66 ; however, their sensitivity and specificity for early detection are low. 67 It has recently been shown that development of PE is associated with increased levels of e Hsp‐70, e Hsp‐90 and TNFα in blood and plasma.…”

Section: Discussionmentioning

confidence: 99%

First‐trimester plasma extracellular heat shock proteins levels and risk of preeclampsia

Robellada-Zárate

Luna-Palacios

Caballero

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

Preeclampsia (PE) occurs annually in 8% of pregnancies. Patients without risk factors represent 10% of these. There are currently no first‐trimester biochemical markers that accurately predict PE. An increase in serum 60‐ and 70‐KDa extracellular heat shock proteins (eHsp) has been shown in patients who developed PE at 34 weeks. We sought to determine whether there is a relationship between first‐trimester eHsp and the development of PE. This was a prospective cohort study performed at a third level hospital in Mexico City from 2019 to 2020. eHsp levels were measured during the first‐trimester ultrasound in singleton pregnancies with no comorbidities. First‐trimester eHsp levels and biochemical parameters of organ dysfunction were compared between patients who developed preeclampsia and those who did not. All statistical analyses and model of correlation (r) between eHsp and clinical parameter were performed using bootstrapping R‐software. p‐values <0.05 were considered significant. The final analysis included 41 patients. PE occurred in 11 cases. eHsp‐60 and eHsp−70 were significantly higher at 12 weeks in patients who developed PE (p = 0.001), while eHsp‐27 was significantly lower (p = 0.004). Significant differences in first‐trimester eHsp concentration suggest that these are possible early biomarkers useful for the prediction of PE.

show abstract

Section: Discussionmentioning

confidence: 99%

First‐trimester plasma extracellular heat shock proteins levels and risk of preeclampsia

Robellada-Zárate

Luna-Palacios

Caballero

et al. 2023

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Similar to our current study, gestational age related to the marked decline in umbilical artery PI has been reported [53], which reflects placental villous circulation.in addition; there was an inverse relation ship between both doppler indices and blood flow velocity [53][54][55][56], Moreover, Wladimiroff et al [57] calculated mean RI values at different gestational ages among normal pregnant women. Therefore, noninvasive color and pulsed wave Doppler sonography have been used to evaluate uterine and umbilical blood flow changes during normal pregnancy during different gestational months at different ages, as the changes in these two parameters provide a picture of intrauterine fetal development, as previously mentioned in pregnant buffalos [58,59], sheep [60], queens [61], and bitchs [62]. The use of Doppler spectral ultrasound in gestational observation in donkey species is recommended to prevent any pregnancy loss and abnormal placental development, with the estimation of uterine and umbilical vascularity.…”

Section: Discussionmentioning

confidence: 99%

The effects of aging and gestational month on uteroplacental vascular perfusion, and umbilical artery hemodynamics in pregnant jennies

et al. 2022

View full text Add to dashboard Cite

This study aimed to correlate the pulsed wave spectral indices of the middle uterine artery at both sides with placental development in jenny within mid-late pregnancies, and establish umbilical Doppler values for different ages and different gestational months. Twenty Equus Asinus pregnant jennies 260–450 kg (average, 320 ± 10 kg) were examined from 5 to 9 months of pregnancy with different ages (4–14 years). Monthly B-mode ultrasound examination was performed on both the combined thickness of the uterus and placenta (CTUP; mm) and umbilical artery cross-sectional diameter, and Doppler mode examination was performed on both the middle uterine (MUA at right [R] and left [L] sides) and umbilical arteries to measure both Doppler indices that expressed by resistance (RI) and pulsatility indices (PI), and blood flow rate. CTUP was elevated within pregnancy time at different ages (P < 0.05). L. PI was significantly declined throughout different ages (P < 0.05), but this declining trend was not observed in L. RI. The L. blood flow rate (R; bpm) was elevated among different ages and different months (P < 0.05). Both RI and PI were significantly decreased from 5 to 9 month of gestation period in jennies (P < 0.05).. The umbilical arteries cross-sectional diameter (Umb A; mm), was elevated among different ages and different months, while both Doppler indices were declined. A positive correlation was found (between both Doppler indices of both umbilical and uterine arteries P < 0.001). There was elevated vascular perfusion in uterine and umbilical arteries associated with reduced both Doppler indices along the course of pregnancy at different ages.

show abstract

“…18 anos. Da amostra total, 71.8% tinham atividade exclusivamente no lar, a maioria, 31.8% viviam sem salário, 18.2% com até um salário-mínimo, 85.4% eram casadas ou com relação estável e 84.5% se consideravam parda.…”

unclassified

Impactos da exposição pré-natal ao mercúrio sobre a hipertensão arterial em parturientes na região do Xingu-Amazônia

Granato¹,

Nogueira²,

Silva³

et al. 2023

Acervo Saúde

View full text Add to dashboard Cite

Objetivo: Investigar a prevalência da hipertensão arterial sistêmica e sua associação com a exposição pré-natal ao mercúrio em parturientes da região do Xingu. Métodos: Estudo observacional, transversal, prospectivo conduzido com 110 parturientes com idade de 15 a 40 anos. As usuárias foram investigadas quanto ao perfil socioeconômico, clínico, obstétrico e quantidade de mercúrio no cabelo. Resultados: A amostra apresentou maioria com atividade exclusivamente do lar, casadas e com o ensino fundamental cursado. 79.1% apresentaram idade gestacional entre 37 e 40 semanas. 13.6% eram primíparas, nenhuma fumava e 3.6% ingeriam álcool. A maioria apresentou hipertensão arterial sistêmica sistólica, 4.6% diastólica e 31.8% ambos os tipos. 99.05% apresentaram concentração de mercúrio total no cabelo < 2µg/g e baixo consumo semanal de peixe. Não foi observado associações estatisticamente significativas de mercúrio total com qualquer medida de pressão arterial sistólica ou diastólica e nem entre hipertensão arterial sistólica e a frequência de consumo de peixes. Observou-se diferença significativa na associação entre a hipertensão diastólica e mista com o consumo semanal de peixes. Conclusão: A referida população possui hipertensão arterial, baixo nível de exposição ao mercúrio ambiental e baixo consumo de peixe, embora sejam residentes em áreas potencialmente poluídas pelo mercúrio ambiental.

show abstract

Uterine vascular resistance and other maternal factors associated with the risk of developing hypertension during pregnancy

Cited by 6 publications

References 22 publications

First‐trimester plasma extracellular heat shock proteins levels and risk of preeclampsia

First‐trimester plasma extracellular heat shock proteins levels and risk of preeclampsia

The effects of aging and gestational month on uteroplacental vascular perfusion, and umbilical artery hemodynamics in pregnant jennies

Impactos da exposição pré-natal ao mercúrio sobre a hipertensão arterial em parturientes na região do Xingu-Amazônia

Contact Info

Product

Resources

About