Uterine Tumors Resembling Ovarian Sex Cord Tumors in Four Baboons (Papio spp.)

Abstract

Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are rare uterine neoplasms that exhibit prominent sex cord-like differentiation. The authors describe 4 cases of UTROSCTs that were identified as incidental lesions in female baboons. All baboons were in good body condition. One animal had a 2-mm-diameter yellow-tan mass in the uterine body along the attachment of the left broad ligament; the other 3 did not have any gross lesions in the uterus. Histologically, the myometrium contained multifocal well-demarcated neoplasms composed of cuboidal to columnar cells arranged in variable arrangements of sheets, nests, cords, trabecular, and retiform patterns that occasionally formed Call-Exner-like bodies. In all cases, the neoplastic cells were diffusely positive for WT-1 and negative for calretinin, CD99, and desmin. One case was positive for inhibin and CD10. To the best of the authors' knowledge, this is the first report of UTROSCTs in nonhuman primates and in the veterinary literature.

A U.S. Option Playbook for Contingency Planning to Reclaim Scarborough Shoal

“…Acting Philippine Supreme Court Chief Justice Antonio Carpio has called on the Philippine government to ask the United States and the Association of Southeast Asian Nations to make Scarborough Shoal an "official red line." 29 Based on my research and travels to the region, it is time for the United States and its allies to (1) get serious about the idea that China might one day decide to make an artificial island out of Scarborough and 2…”