Uterine tumor resembling ovarian sex cord tumors: Report of a case with ultrastructural study

Kantélip, B.; Cloup, N.; Déchelotte, P.

doi:10.1016/s0046-8177(86)80161-7

Cited by 55 publications

(45 citation statements)

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“…Results have been variable, with ultrastructural and immunohistochemical evidence of myogenic, epithelial, and sex cord differentiation. [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] In the present study, we applied a panel of antibodies, inclusive of the most recently identified markers of sex cord differentiation (calretinin, melan A, CD99, and inhibin) as well as smooth muscle and endometrial stroma, to a series of UTROSCT and ESTSCLE. We found that all UTROSCT were immunoreactive for at least two markers of sex cord differentiation, often with coexpression of cytokeratin, CD10, vimentin, estrogen receptor, and progesterone receptor; desmin immunoreactivity, when present, was restricted to minor foci of smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

“…[4][5][6][7] Numerous immunohistochemical and ultrastructural studies have attempted to phenotype the sex cord-like cells in UTROSCT and ESTSCLE, with variable evidence supporting myoid, [8][9][10][11][12][13][14] epithelial, 4,15 and true sex cord differentiation. 6,7,[16][17][18][19][20] Specifically, inhibin and CD99, 3,6,7,14,[17][18][19][20][21] as well as Melan-A, 19,21 and most recently, calretinin, 7,20 have been utilized as immunohistochemical markers of sex cord differentiation in UTROSCT and ESTSCLE based on application of these markers to sex cordstromal tumors of the ovary. [22][23][24][25][26][27][28][29] The present study was initiated following the diagnosis of a UTROSCT exhibiting a striking retiform pattern and Leydig-like stromal cells, indistinguishable from a Sertoli-Leydig cell tumor of the ovary.…”

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Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

2006

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In this study, we present the clinicopathologic features and immunophenotypic characteristics of five cases of uterine tumors resembling ovarian sex cord tumors and three cases of endometrial stromal tumors with sex cord-like elements, with emphasis on immunohistochemical markers of sex cord differentiation. The mean patient age was 42 years (range 19-69 years), and vaginal bleeding was the most common clinical presentation. The tumors were usually polypoid masses arising in the uterine fundus, with a mean tumor size of 6.7 cm. Sex cord patterns in uterine tumors resembling ovarian sex cord tumors, including anastomosing cords, trabeculae, small nests, tubules, and in one case, a striking retiform architecture with Leydig-like cells, comprised from 70 to 100% of the tumor volume. All uterine tumors resembling ovarian sex cord tumors were positive for two or more markers of sex cord differentiation; all five cases showed strong immunoreactivity for calretinin, with coexpression of CD99 (four cases), Melan-A (two cases), and inhibin (two cases). Endometrial stromal tumors with sex cord-like elements were less frequently positive for markers of sex cord differentiation, with each case positive for one marker (calretinin, two cases; CD99, one case). In addition, all eight cases were frequently positive for cytokeratin, CD10, vimentin, estrogen receptor, and progesterone receptor; desmin immunoreactivity, when present, was limited to minor foci of smooth muscle. Overall, the morphologic and immunohistochemical findings in uterine tumors resembling ovarian sex cord tumors strongly support that these unusual uterine tumors are polyphenotypic neoplasms with true sex cord differentiation.

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Section: Discussionmentioning

confidence: 99%

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Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

2006

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“…In the literature, only 38 patients with UTROSCT have been described [1,4,6,9,10,11,13,17,20,21,26,27,28,30,34,37,38]. Their mean age was 48 years (range 16-86 years).…”

Section: Discussionmentioning

confidence: 99%

Uterine tumor resembling ovarian sex-cord tumor – a case report and review of the literature

et al. 2001

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A uterine tumor resembling an ovarian sex-cord tumor (UTROSCT) is a very rare lesion with only 38 cases reported in the literature so far. Here, we show an additional case of a pure UTROSCT with a DNA stemline at 1c in a 49-year-old woman presenting with abnormal vaginal bleeding. Problems in differential diagnosis arise mainly due to the variable histological picture of UTROSCT. Immunohistochemically, these tumors express cytokeratin, epithelial membrane antigen, vimentin, and smooth muscle actin. Moreover, in some cases, CD99 and alpha-inhibin are detectable. Although 36% of UTROSCT have infiltrative margins, almost all of them behave benignly. It is thus questionable whether the same prognostic criteria apply for these tumors as for endometrial stromal sarcomas. However, in the so-called mixed UTROSCT, the endometrial stromal sarcoma component determines the outcome.

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“…The presence of Charcot-Böttcher crystals in the cells of a UTROSCT suggests that some of these lesions have a true Sertoli differentiation. 16 …”

Section: Microscopic Featuresmentioning

confidence: 99%

Uterine Tumors Resembling Ovarian Sex Cord Tumors

Pradhan¹,

Mohanty²

2013

Archives of Pathology &Amp; Laboratory Medicine

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Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare neoplasms of unknown etiology. Only 67 cases have been reported in the literature, to our knowledge, so far. The neoplasm usually occurs in middle-aged women. Most patients present with abnormal uterine bleeding and/or abdominal pain, along with an enlarged uterus or a palpable uterine mass. There is no specific imaging finding, and the diagnosis is made exclusively on histopathologic examination. A multitude of architectural patterns are described, which include plexiform cords, anastomosing trabeculae, watered-silk, microfollicle, macrofollicle, tubules, retiform, solid cellular islands, and diffuse pattern of growth. The neoplastic cells are usually small with round to ovoid nuclei, nuclear monotony, mild nuclear hyperchromasia, and inconspicuous nucleoli with scant eosinophilic cytoplasm. Nuclear grooves are rare. Mitotic figures are infrequent, and necrosis is mostly absent. This tumor depicts a diverse immunohistochemical profile with expression of sex cord, epithelial, and smooth muscle lineages markers. Sex cord markers, such as inhibin, calretinin, CD99, WT1, and MART-1; epithelial markers, such as pancytokeratin and epithelial membrane antigen; smooth muscle markers, such as smooth muscle actin, desmin, and histone deacetylase 8; and miscellaneous markers, such as CD10, estrogen receptor, progesterone receptor, S100, and CD117, are often coexpressed. Immunoexpression for calretinin and at least for one of the other sex cord markers is required to establish a diagnosis of UTROSCT. Hysterectomy with or without bilateral salpingo-oophorectomy is usually the treatment for UTROSCT. Although most UTROSCTs behave benignly, some do recur, and thus, this entity should be considered as a tumor of low malignant potential. In this review, we discuss the current knowledge on UTROSCT and its clinical relevance.

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Uterine tumor resembling ovarian sex cord tumors: Report of a case with ultrastructural study

Cited by 55 publications

References 8 publications

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation

Uterine tumor resembling ovarian sex-cord tumor – a case report and review of the literature

Uterine Tumors Resembling Ovarian Sex Cord Tumors

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