Uterine sarcomas: 7-year experience from a tertiary center

Abstract

Uterine sarcomas are rare and aggressive gynecologic malignancies. Due to their rarity, histopathologic heterogeneity and molecular diversity, the optimal approach is still a matter of debate. Debulking surgery is still the mainstay of the treatment. But adjuvant treatment strategies remain controversial. In this study, we aimed to examine the clinical characteristics, histopathological features, tumoral behavior and recurrence patterns of patients diagnosed with uterine sarcoma at a tertiary referring center over a 7-year period. A total of 427 patients who were treated for uterine cancer between 2007 and 2014 were analyzed retrospectively. There were in total 20 patients diagnosed with uterine sarcoma. Median age of all patients diagnosed as uterine sarcomas was 50.5 years [interquartile range 11.5 (43.5-55)]. The median tumor size in these patients was 5.75 cm [interquartile range 4.38 (4.12-8.50)]. There were 5 patients with leiomyosarcomas, 10 patients with endometrial stromal sarcomas, 4 patients with undifferentiated uterine sarcomas and 1 patient with adenosarcoma. Despite our limited data, we presented our retrospective series over a period of 7 years. Prospective data and further insights are needed to better understand the tumor biology and improve treatment modalities.