Uterine Relaxant Properties of Viburnum

Jarboe, Charles H.; Schmidt, Charlotte M.; Nicholson, John; Zirvi, Karimullah A.

doi:10.1038/212837a0

Cited by 20 publications

(12 citation statements)

References 6 publications

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“…Cramp bark and black haw are two species of viburnum that are often used as uterine relaxants and antispasmodics. Animal studies have suggested that both species have antispasmodic effects on the uterus and experiments with human uterine tissue also showed a relaxant effect ( Jarboe et al, 1966 ; Nicholson et al, 1972 ; Cometa et al, 2009 ). Scopoletin could be responsible for the smooth muscle antispasmodic activity of viburnum ( Fig.…”

Section: Botanicals Used By Premenopausal Womenmentioning

confidence: 99%

Botanicals and Their Bioactive Phytochemicals for Women’s Health

et al. 2016

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Botanical dietary supplements are increasingly popular for women’s health, particularly for older women. The specific botanicals women take vary as a function of age. Younger women will use botanicals for urinary tract infections, especially Vaccinium macrocarpon (cranberry), where there is evidence for efficacy. Botanical dietary supplements for premenstrual syndrome (PMS) are less commonly used, and rigorous clinical trials have not been done. Some examples include Vitex agnus-castus (chasteberry), Angelica sinensis (dong quai), Viburnum opulus/prunifolium (cramp bark and black haw), and Zingiber officinale (ginger). Pregnant women have also used ginger for relief from nausea. Natural galactagogues for lactating women include Trigonella foenum-graecum (fenugreek) and Silybum marianum (milk thistle); however, rigorous safety and efficacy studies are lacking. Older women suffering menopausal symptoms are increasingly likely to use botanicals, especially since the Women’s Health Initiative showed an increased risk for breast cancer associated with traditional hormone therapy. Serotonergic mechanisms similar to antidepressants have been proposed for Actaea/Cimicifuga racemosa (black cohosh) and Valeriana officinalis (valerian). Plant extracts with estrogenic activities for menopausal symptom relief include Glycine max (soy), Trifolium pratense (red clover), Pueraria lobata (kudzu), Humulus lupulus (hops), Glycyrrhiza species (licorice), Rheum rhaponticum (rhubarb), Vitex agnus-castus (chasteberry), Linum usitatissimum (flaxseed), Epimedium species (herba Epimedii, horny goat weed), and Medicago sativa (alfalfa). Some of the estrogenic botanicals have also been shown to have protective effects against osteoporosis. Several of these botanicals could have additional breast cancer preventive effects linked to hormonal, chemical, inflammatory, and/or epigenetic pathways. Finally, although botanicals are perceived as natural safe remedies, it is important for women and their healthcare providers to realize that they have not been rigorously tested for potential toxic effects and/or drug/botanical interactions. Understanding the mechanism of action of these supplements used for women’s health will ultimately lead to standardized botanical products with higher efficacy, safety, and chemopreventive properties.

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Section: Botanicals Used By Premenopausal Womenmentioning

confidence: 99%

Botanicals and Their Bioactive Phytochemicals for Women’s Health

et al. 2016

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“…In our opinion, this is the first evidence putting light on the possible active compounds of Viburnum prunifolium, indicating a new interesting approach to pharmacological studies on the plant (Mariott and Munch, 1946;Grote and Woods, 1947;Hörhammer et al, 1966Hörhammer et al, , 1967Jarboe et al, 1966Jarboe et al, , 1967Ojewole, 1984).…”

Section: Discussionmentioning

confidence: 91%

“…ethanolic extraction or aqueous decoction), various drug administrations (oral and intravenous), or to common inert adulterant in Viburnum prunifolium for biological assays (American Herbal Pharmacopoeia, 2000). Apart from a few compounds identified as being possibly responsible for the properties of Viburnum prunifolium (Mariott and Munch, 1946;Grote and Woods, 1947;Hörhammer et al, 1966Hörhammer et al, , 1967Jarboe et al, 1966;Ojewole, 1984), several unidentified constituents showing spas- molytic activity on different isolated smooth muscles were reported (Jarboe et al, 1967). As a consequence of this situation, Black Haw is still largely unrecognized by the public and conventional medical professionals and it is absent from modern pharmacopoeia with the exception of British Herbal Pharmacopoeia (1983) and American Herbal Pharmacopoeia and Therapeutic Compendium (2000).…”

Section: Introductionmentioning

confidence: 96%

“…The root and stem barks of Viburnum prunifolium L. (Caprifoliaceae), or Black Haw, a deciduous shrub of North America, are well known in folk medicine for their spasmolytic, sedative, and anti-asthmatic properties (Jarboe et al, 1966;British Herbal Pharmacopoeia, 1983;American Herbal Pharmacopoeia, 2000). Furthermore, as well as many other Viburnum species, Viburnum Abbreviations: BuOH fraction, n-butanol fraction; CC, column chromatography; DMSO, dimethyl sulfoxide; MeOH extract, methanolic extract; EtOAc fraction, ethylacetate fraction; HPLC, high performance liquid chromatography; MeOH, methanol; UV, ultraviolet.…”

Section: Introductionmentioning

confidence: 99%

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In vitro relaxant and spasmolytic effects of constituents from Viburnum prunifolium and HPLC quantification of the bioactive isolated iridoids

Cometa

Parisi

Palmery

et al. 2009

Journal of Ethnopharmacology

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“…Six species of genus viburnum (viburnum cotonifolium, viburnum tinus, viburnum cylindricum, viburnum opulus, viburnum mullaha, viburnum grandiflorum) distributed in Pakistan. The genus viburnum is well known in folk medicine for their spasmolytic, sedative and anti-asthmatic properties (Jarboe et al, 1966). Viburnum prunifolium specifically *Corresponding author.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Viburnum grandiflorum for its in-vitro pharmacological screening

Alam¹

2012

Afr. J. Pharm. Pharmacol.

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In the present study the crude ethanolic and its succeeding solvent fractions of the aerial and roots parts of Viburnum grandiflorum were investigated for their in-vitro pharmacological (antifungal, phytotoxic and insecticidal) profile. In case of antifungal activity the n-hexane fraction was active against Microsporum canis having 35 percent zone of inhibition and ethyl acetate fraction were active against Fusarium solani with 10% zone of inhibition. The ethyl acetate fraction of aerial part was the most significant antifungal against F. solani with 30% zone of inhibition while the crude extract was 10% active against M. cani. The n-hexane, chloroform fractions and ethanolic extract of the root were significant phytotoxic having 70, 75 and 80% inhibition respectively. In case of aerial part the most significant phytotoxic effect was revealed by ethyl acetate with 85% inhibition followed by ethanolic extract with 80% growth of inhibition. The crude ethanolic extract of the aerial part showed 20, 40 and 40% mortality against Tribolium castaneum, Callosbruchus analis and Rhyzopertha dominica respectively. The n-hexane, chloroform and ethyl acetate fractions showed 20% mortality against C. analis and R. dominica. All the tested samples were significant insecticidal against R. dominica. The nhexane fraction of root was failed to produce any insecticidal effect, while the chloroform fraction was effective against C. analis and R. dominica with 20% mortality. The crude ethanolic extract and its ethyl acetate fraction showed 40% mortality C. analis and R. dominica.

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Uterine Relaxant Properties of Viburnum

Cited by 20 publications

References 6 publications

Botanicals and Their Bioactive Phytochemicals for Women’s Health

Botanicals and Their Bioactive Phytochemicals for Women’s Health

In vitro relaxant and spasmolytic effects of constituents from Viburnum prunifolium and HPLC quantification of the bioactive isolated iridoids

Evaluation of Viburnum grandiflorum for its in-vitro pharmacological screening

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