Uterine prostaglandin levels following stimulation of the decidual cell reaction: Effects of indomethacin and tranylcypromine

Jonsson, Haldor T.; Rankin, J. C.; Ledford, Barry E.; Baggett, Billy

doi:10.1016/0090-6980(79)90122-9

Cited by 25 publications

(18 citation statements)

References 23 publications

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“…For mice, there are varying reports for the effects of deciduogenic stimuli. Jonsson et al (1979), Rankin et al (1979) and Milligan & Lytton (1983) all found the PGF 2a concentrations to be rapidly increased after stimulation. Jonsson et al (1979) reported that PGE 2 was also increased, while Milligan & Lytton (1983) found PGE 2 as well as PGI 2 to be unchanged.…”

Section: Which Pg?mentioning

confidence: 99%

“…However, at best only a partial restoration of decidualization was obtained, possibly because elevated uterine concentrations of PGs were achieved only for a brief period following the injection. Additional evidence that PGI 2 may mediate the decidual cell reaction in mice comes from the work of Jonsson et al (1979), who found that tranylcypromine, purportedly a selective inhibitor of PGI 2 synthesis, inhibits decidualization. However, the specificity of this inhibitory action of tranylcypromine has been questioned (Rajtar & de Gaetano 1979, Buxton & Murdoch 1982.…”

Section: Which Pg?mentioning

confidence: 99%

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Prostaglandins and the initiation of blastocyst implantation and decidualization

Kennedy¹,

Gillio-Meina²,

Phang³

2007

Reproduction

136

122

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The process of blastocyst implantation in mammals is remarkably variable, especially in the extent of trophoblast invasion of the endometrium. In most species studied, the earliest macroscopically identifiable sign of blastocyst implantation is an increase in endometrial vascular permeability in areas adjacent to the blastocysts. This is followed in species with invasive implantation by decidualization, again localized to areas adjacent to the blastocysts. In some species, the application of a stimulus to the endometrium can result in increased endometrial vascular permeability and decidualization. Based initially on studies utilizing inhibitors of prostaglandin (PG) synthesis and more recently on studies using the techniques of transgenics, considerable evidence has accumulated indicating that PGs have an important role in the early events of implantation and artificially induced decidualization. However, which PGs are involved remains controversial. There may be differences between species, and different PGs may be involved at different times.

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Section: Which Pg?mentioning

confidence: 99%

Section: Which Pg?mentioning

confidence: 99%

Prostaglandins and the initiation of blastocyst implantation and decidualization

Kennedy¹,

Gillio-Meina²,

Phang³

2007

Reproduction

136

122

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“…This is shown by trauma causing decidualization in the appropriate endocrine milieu [2], the possible role of histamine [3], the mac rophage response in deciduali/ation [4] and the role of prostaglandins [5]. It is known that semen contains lysozymes, prostaglandins [6,7] and excites a macrophage response [8].…”

Section: Introductionmentioning

confidence: 99%

Influence of Insemination on the Implantation of Transferred Rat Blastocysts

Carp

Serr

Mashiach

et al. 1984

Gynecol Obstet Invest

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Embryo transfer probably produces a lower incidence of implantation than the physiological incidence despite all other factors seeming similar. The only factor known to be present physiologically and absent in embryo transfer is the presence of sperm in the uterine cavity. Implantation and deciduahzation are often considered a modified form of inflammatory reaction. Semen contains factors which excite an inflammatory response. This project attempted to determine whether insemination would affect the implantation rate of transferred blastocysts in the rat. The figures showed a significantly increased implantation rate after insemination at day 4 of pseudopregnancy as compared to controls.

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“…Miller and O'Morchoe (1982) found that indomethacin did not affect the decidualization in response to intrauterineadministered prostaglandin F2a. Jonsson et al (1979) have suggested that prostaglandin 12 may be a mediator of decidualization in mice since tranylcypromine, purportedly a selective inhibitor of prostaglandin 12 synthesis (Gryglewski et al 1976), inhibits decidualization. However, the specificity of this inhibitory action of tranylcypromine has been questioned (Raj tar and de Gaetano 1979; Buxton and Murdoch 1982}, and the inhibition has not been overriden with prostaglandin 12, Because of its chemical instability in aqueous solutions at neutral pH, it is difficult to determine the biological activity of prostaglandin 12.…”

Section: Which Prostaglandins?mentioning

confidence: 99%

Embryonic signals and the initiation of blastocyst implanation.

Kennedy¹

1983

Aust. Jnl. Of Bio. Sci.

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The earliest sign of blastocyst implantation is an increase in endometrial vascular permeability which is localized in areas adjacent to blastocysts. The localized nature of this response suggests that it occurs in response to a signal from the blastocyst. It has been suggested that this signal may be physical in nature, or may be due to blastocyst-produced histamine, oestrogen or prostaglandins. The evidence for each of these is reviewed. At present, it is not possible to exclude any of these signals, which are not mutually exclusive, with certainty. The bulk of the evidence suggests that prostaglandins have an obligatory role in the initiation of implantation, but they may not necessarily be of blastocyst origin.

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Uterine prostaglandin levels following stimulation of the decidual cell reaction: Effects of indomethacin and tranylcypromine

Cited by 25 publications

References 23 publications

Prostaglandins and the initiation of blastocyst implantation and decidualization

Prostaglandins and the initiation of blastocyst implantation and decidualization

Influence of Insemination on the Implantation of Transferred Rat Blastocysts

Embryonic signals and the initiation of blastocyst implanation.

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