Uterine Peristalsis and the Development of Endometriosis and Adenomyosis

Leyendecker, G.; Wildt, L.

doi:10.1002/9781444398519.ch20

Cited by 5 publications

(7 citation statements)

References 85 publications

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“…61 Leyendecker and Wildt reproduced this drawing as figure 20.1 in a chapter emphasizing the importance of uterine peristalsis in the development of endometriosis as well as adenomyosis. 62 The 4 developmental müllerian diseases are different from the 4 acquired müllerian diseases. Acquired endometriosis and acquired endosalpingiosis are common diseases characterized by invasion of the surface of normal organs by endometrial or endosalpingeal tissue; acquired adenomyosis is a common condition characterized by invasion of the myometrium by endometrium; acquired endocervicosis is an uncommon lesion resulting from surgical transplantation of endocervical tissue during hysterotomy.…”

Section: Discussionmentioning

confidence: 99%

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Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases

Batt

Yeh

2013

Reprod. Sci.

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The theory of müllerianosis predicts that embryonic müllerian tissue, misplaced during organogenesis, results in the formation of 4 benign müllerian diseases-developmental adenomyosis, endometriosis, endosalpingiosis, and endocervicosis-(developmental müllerian diseases) that will be identified in human female fetuses, infants, children, adolescents, and adults. Direct evidence is presented to support the existence of developmental adenomyosis, developmental endometriosis, and developmental endocervicosis in human female fetuses along with strong circumstantial evidence supporting the existence of all 4 developmental müllerian diseases in human female infants, children, adolescents, and adults. This evidence throws light upon the pathogenesis of rare müllerian lesions whose pathogenesis remains inexplicable by classical and modern theories. Furthermore, this research has scientific and clinical relevance: scientific relevance because it opens up a new field of comparative research-the 4 developmental müllerian diseases complement the 4 acquired müllerian diseases; clinical relevance because it identifies rare müllerian diseases curable by complete surgical excision.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases

Batt

Yeh

2013

Reprod. Sci.

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“…Adenomyosis is defined as the presence of endometrial tissue in the uterine muscle wall. In the past endometriosis and adenomyosis were considered to be the same disease [2].…”

Section: Abstract: Endometriosis Adenomyosis Immunohistochemistry mentioning

confidence: 99%

Gynecological Symptoms Correlated with Immunohistochemical Aspects of Endometriosis and Adenomyosis

Penciu¹,

Postolache²,

Tica³

et al. 2019

Rev. Chim.

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Endometriosis is a benign disease characterized by the presence of endometrial tissue outside the uterus. It is more associated to chronic pelvic pain, dysmenorrhea and dyspareunia. Adenomyosis is represented by the presence of endometrial tissue inside the uterine muscle. We studied, in 100 successive patients, immunohistochemical markers CD10, CD34 and KI67 in glandular and in stromal cells, in order to assess the correlation between symptoms and them. We did not find any data reporting these aspects. As CD34 is an angiogenesis marker and Ki67 is an aggressivity marker, pelvic pain could predict a more aggressive disease and with a higher spreading capacity in patients with endometriosis. In the same patients, and dysmenorrhea seems to be related with only with angiogenesis.

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“…The myometrium is exposed to at least two functionally and structurally distinct zones: the sub-endometrial or junctional zone and the outer myometrium (46,(50)(51)(52)(53)(54).…”

Section: Hyper-and Dysperistalsismentioning

confidence: 99%

“…The adenomyosis-related myometrium is more compact than the non-affected myometrium. Overexpression of OTR, which appears in 50% of the cases, and metaplastic activity of adenomyotic cells result in myometrial hyper-plasticity/metaplasia (53)(54)(55)(56)(57)(58)(59)(60). The structure disorder promotes peristalsis and leads to pain.…”

Section: Hyper-and Dysperistalsismentioning

confidence: 99%

How to Understand the Complexity of Endometriosis-Related Pain

Chiàntera

Abesadze

Mechsner

2017

Journal of Endometriosis and Pelvic Pain Disorders

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women of reproductive age are affected by endometriosis. Severe symptoms characterized by endometriosis include: dysmenorrhea, dyspareunia, dyschezia, dysuria, cyclic and acyclic pelvic pain, menstrual disorders and infertility. These symptoms have extreme human, clinical and economic relevance (1, 2). Although they are relatively specific for endometriosis, there is normally a long delay between the onset of symptoms and establishing an official diagnosis. Frequently, the final diagnosis occurs after 10 visits to different physicians (3). The current average time of diagnosis is between 6-8 years. The wide range of many other nonspecific symptoms such as bowel and bladder complaints, emission of pain in the legs, vegetative concomitants like vomiting, emesis, gastric disorders, headaches, dizziness, painful ovulation, irregular pelvic pain, lower back pain, chronic fatigue (Tab. I) could be the reason for that. This leads to a misunderstanding of the situation and often to the incorrect diagnosis. Gynecologists should have a

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Uterine Peristalsis and the Development of Endometriosis and Adenomyosis

Cited by 5 publications

References 85 publications

Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases

Müllerianosis: Four Developmental (Embryonic) Müllerian Diseases

Gynecological Symptoms Correlated with Immunohistochemical Aspects of Endometriosis and Adenomyosis

How to Understand the Complexity of Endometriosis-Related Pain

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