Uterine Papillary Serous Carcinoma

Dunton, Charles J.; Balsara, Gulnar; McFarland, Miles; Hernández, Enrique

doi:10.1097/00006254-199102000-00014

Cited by 75 publications

(40 citation statements)

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“…Clear cell and serous papillary carcinomas are considered to be aggressive histological subtypes and are associated with a worse prognosis than endometrioid adenocarcinoma [32][33][34]. Therefore in surgical planning, and for the purpose of this study, they are taken to represent the equivalent of grade 3 endometrioid adenocarcinomas, giving a total of 7 patients with grade 3 histopathology.…”

Section: Histopathologymentioning

confidence: 99%

Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer

Bharwani

Miquel²,

Sahdev³

et al. 2011

BJR

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Objective: Endometrial cancer is the most common gynaecological malignancy in developed countries. Histological grade and subtype are important prognostic factors obtained by pipelle biopsy. However, pipelle biopsy ''samples'' tissue and a high-grade component that requires more aggressive treatment may be missed. The purpose of the study was to assess the use of diffusion-weighted MRI (DW-MRI) in the assessment of tumour grade in endometrial lesions. we obtained a sensitivity, specificity, positive predictive value and negative predictive value for malignancy of 87%, 100%, 100% and 85.7%, respectively. Conclusion: Tumour mean and minimum ADC values are not useful in differentiating histological tumour grade in endometrial carcinoma. However, mean ADC measurement can provide useful information in differentiating benign from malignant endometrial lesions. This information could be clinically relevant in those patients where pre-operative endometrial sampling is not possible.

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Section: Histopathologymentioning

confidence: 99%

Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer

Bharwani

Miquel²,

Sahdev³

et al. 2011

BJR

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“…UPSCs behave similarly to serous ovarian carcinomas in their propensity for i.p. spread (13). To mimic this behavior, transfected SPEC2 cells were inoculated i.p.…”

Section: Hoxa10 (mentioning

confidence: 99%

“…Grade 3 (G 3 ) endometrioid carcinomas are mostly solid, whereas uterine papillary serous carcinoma (UPSC) is characterized by papillary patterns of growth. Although histologically distinct, G 3 endometrioid carcinoma and UPSC share several common features including high-grade nuclear atypia and poor responsiveness to chemotherapy, radiation, and progestin therapy (11)(12)(13). G 3 endometrioid carcinoma and UPSC have greater propensity for myometrial and lymphatic/vascular space invasion than G 1 tumors (11)(12)(13), but the mechanisms underlying the progression of these high-grade tumors are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

Deregulation of the HOXA10 Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition

Yoshida¹,

Broaddus

Cheng³

et al. 2006

Cancer Research

122

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Homeobox genes encode transcription factors that control cell differentiation and play essential roles in developmental patterning. Increasing evidence indicates that many homeobox genes are aberrantly expressed in cancers, and that their deregulation significantly contributes to tumor progression. The homeobox gene HOXA10 controls uterine organogenesis during embryonic development and functional endometrial differentiation in the adult. We investigated whether HOXA10 expression is deregulated in endometrial carcinomas, and how counteracting this aberrant expression modifies tumor behavior. We found that down-regulation of HOXA10 expression in endometrial carcinomas strongly correlates with increased tumor grade and is associated with methylation of the HOXA10 promoter. Enforced expression of HOXA10 in endometrial carcinoma cells inhibited invasive behavior in vitro and tumor dissemination in nude mice. The inhibitory effect of HOXA10 on invasive behavior was attributable at least in part to the ability of HOXA10 to induce expression of the epithelial cell adhesion molecule E-cadherin by downregulating expression of Snail, a repressor of E-cadherin gene transcription. These findings reveal a novel role for HOXA10 deregulation in the progression of endometrial carcinoma by promoting epithelial-mesenchymal transition. (Cancer Res 2006; 66(2): 889-97)

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“…1 Whereas endometrioid carcinoma has relatively good cure rates, endometrial carcinomas containing a serous component have a much poorer prognosis, even in patients with early-stage disease. [2][3][4][5][6][7][8][9][10][11] In a review of uterine serous carcinomas (USCs), women with FIGO Stage I disease had a 5-year survival rate of 60%, compared with a 5-year survival rate of 80 -90% in patients with Stage I endometrioid carcinoma. 2 Although the overall survival (OS) in women with USC is reported to be inferior to the OS in women with endometrioid carcinoma in general, to our knowledge no difference has specifically been established between USC and its poorly differentiated endometrioid counterpart.…”

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confidence: 99%

Uterine serous and grade 3 endometrioid carcinomas

Boruta

Gehrig

Groben

et al. 2004

Cancer

100

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BACKGROUNDSerous components within endometrial carcinoma are reportedly poor prognosticators. However, to the authors' knowledge the percentage of tumors which must be comprised of a serous component in order to affect outcome is unknown. The authors compared overall survival (OS) in women with endometrial carcinomas comprised of various percentages of uterine serous carcinoma (USC) with that of women with International Federation of Gynecology and Obstetrics (FIGO) Grade 3 endometrioid carcinoma (G3EC) to determine whether outcomes varied between these two poorly differentiated histologies.METHODSData concerning women with either G3EC or USC who were diagnosed between January 1990 and November 2000 were collected retrospectively. Cases were reviewed to confirm diagnosis and estimate the fraction of tumor comprised of USC. Variables assessed included patient age and race, tumor stage, and lymphovascular space invasion. Associations between variables were tested using the Fisher exact test. The Kaplan–Meier method was used to evaluate OS with comparisons performed using the log‐rank test.RESULTSFifty‐two women with G3EC and 87 women with USC were identified. The OS of women with tumors comprised of > 50% USC was found to be significantly worse compared with women with G3EC (hazard ratio [HR] of 2.4; 95% confidence interval [95% CI], 1.2–5.2). Women with USC were more likely to present with extrauterine disease (odds ratio of 2.2; 95% CI, 1.1–4.5). The 5‐year survival rate for women with G3EC was 75% compared with 41% for women with tumors that were > 50% USC (P = 0.01). There was a significant trend toward a worse OS in women with even 10% USC compared with women with G3EC.CONCLUSIONSUSC involving > 50% of an endometrial carcinoma was found to be predictive of worse OS compared with the OS of women with G3EC. In patients with early‐stage disease, a trend toward a worse prognosis was found to exist when USC comprised even 10% of a tumor. Investigation into the treatment of endometrial carcinoma should include and document tumors with any percentage comprised of USC. Cancer 2004. © 2004 American Cancer Society.

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Uterine Papillary Serous Carcinoma

Cited by 75 publications

References 0 publications

Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer

Diffusion-weighted imaging in the assessment of tumour grade in endometrial cancer

Deregulation of the HOXA10 Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition

Uterine serous and grade 3 endometrioid carcinomas

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